While the prevalence of cigarette smoking has been decreasing steadily over the last 40 years, the use of alternative tobacco products has risen markedly over the last decade, particularly among young adults.
The aim of these three interrelated exploratory research proposals are to 1) advance our understanding of attitudes, risk perception and use of emerging tobacco and nicotine delivery products, including electronic cigarettes and hookah, among low income, minority and immigrant young adults ages 18-30 enrolled in one of the 23 colleges of the City University of New York (CUNY), 2) to assess the communication channels young adults use to seek and share information and the nature and extent of this communication about electronic cigarettes and hookah, and 3) to assess the health implications of one of these emerging products, hookah, an example of a culturally-linked method of tobacco smoking. To achieve these aims we will survey 1,500 students attending City University of New York, the largest and one of the most diverse public university systems in the U.S. (75% racial/ethnic minority). We will supplement the quantitative survey data with focus groups among water pipe tobacco smokers and electronic cigarette users, as well as among those with high intention of using these products in the next 6 months: Finally, we will assess the content of water pipe tobacco smoke and its health effects. Hookah smokers, recruited from the CUNY survey, will be monitored for cardiovascular and pulmonary effects after exposure to mainstream hookah smoke. In addition, airway epithelial cells will be collected from sputum samples separated by flow cytometry and assayed for mRNA changes in cancer-related genes. Hookah/water pipes have become the second most common form of tobacco used (after cigarettes) in some US populations and a surge in marketing for electronic cigarettes has coincided with dramatic increases in awareness and use (5 fold increase in use from 2010-2012). For both products, the alarming growth in use is highest among young adults. Yet, little is known about factors leading to initiation, patterns of use, including dual use of products, and how young adults obtain and exchange information of these products. Moreover, despite a history of industry targeting vulnerable populations, there are a lack of data on how use of nontraditional products varies by race/ethnicity and gender. This application brings together experts in environmental sciences and tobacco control, bridging the study of patterns of product use and potential toxicity. Consistent with FDA specified research goals the application represents an important step towards elucidating patterns of communication and potential public health risks posed by electronic cigarettes and Hookah that will help inform regulations related to these products.

Public Health Relevance

The use of alternative tobacco products in the US has been rising markedly over the last decade, dramatically outpacing the scientific evidence available on these products. This revision application focuses on two of the most common - water pipe tobacco and e-cigarettes. We will assess prevalence of water pipe and e-cigarette use in a diverse, urban young adult population, and then evaluate how people obtain and share information about these products. Finally we will evaluate the exposure to mainstream particles and gases generated by water pipe tobacco smoking, as well as the adverse health effects and elevated biomarkers of risk produced by exposure to water pipe tobacco smoke.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA016087-34S1
Application #
8642431
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Ptak, Krzysztof
Project Start
1996-12-01
Project End
2015-02-28
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
34
Fiscal Year
2014
Total Cost
Indirect Cost
Name
New York University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
Huang, Chao; Zeng, Xingruo; Jiang, Guosong et al. (2017) XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell. J Hematol Oncol 10:6
Silvera, Deborah; Ernlund, Amanda; Arju, Rezina et al. (2017) mTORC1 and -2 Coordinate Transcriptional and Translational Reprogramming in Resistance to DNA Damage and Replicative Stress in Breast Cancer Cells. Mol Cell Biol 37:
Koh, Hyunwook; Blaser, Martin J; Li, Huilin (2017) A powerful microbiome-based association test and a microbial taxa discovery framework for comprehensive association mapping. Microbiome 5:45
Ma, Lijie; Liu, Yan; Landry, Nichole K et al. (2017) Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia. PLoS One 12:e0186769
Morabito, Michael V; Ravussin, Yann; Mueller, Bridget R et al. (2017) Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain. PLoS One 12:e0168226
Koetz-Ploch, Lisa; Hanniford, Douglas; Dolgalev, Igor et al. (2017) MicroRNA-125a promotes resistance to BRAF inhibitors through suppression of the intrinsic apoptotic pathway. Pigment Cell Melanoma Res 30:328-338
Feig, Jessica L; Mediero, Aranzazu; Corciulo, Carmen et al. (2017) The antiviral drug tenofovir, an inhibitor of Pannexin-1-mediated ATP release, prevents liver and skin fibrosis by downregulating adenosine levels in the liver and skin. PLoS One 12:e0188135
Ono, Kentaro; Viet, Chi T; Ye, Yi et al. (2017) Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling. Sci Rep 7:9181
Wang, Xing; Zhang, Fenglin; Wu, Xue-Ru (2017) Inhibition of Pyruvate Kinase M2 Markedly Reduces Chemoresistance of Advanced Bladder Cancer to Cisplatin. Sci Rep 7:45983
Garré, Juan Mauricio; Silva, Hernandez Moura; Lafaille, Juan J et al. (2017) CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-?. Nat Med 23:714-722

Showing the most recent 10 out of 1082 publications