The Cancer Immunology (CI) Research Program evolved from the former Immunology and Immunotherapy research program. The previous immunology and Immunotherapy program was centered around basic immunology wherein only some investigators had cancer immunology as their primary interest In contrast, the present CI program has cancer-directed immunology research as its nucleus, supported by the research and fertile environment provided by the more basic immunology community at Yale. Several programmatic developments enabled this evolution;First, new recruitments have bolstered cancer immunology research. Secondly, existing CI members have expanded their research efforts in cancer-specific studies. Third, there has been a dramatic increase in the number of cancer immunology clinical trials. Finally, the clinical success of immune modulators has increased the prestige of cancer immunology and subsequently the interest in it by the Yale immunology community. The CI Research Program is still invested in supporting the "basic" research activities of the program, which is among the most productive in the field of immunology. In addition to its intrinsic value, this research creates a dynamic and fertile environment that adds to the cancer mission and which facilitates the recruitment of cancer immunologists. The central themes and scientific goals of the CI Program: 1. Identify cellular and molecular mechanisms that inhibit spontaneous immune responses against cancer cells in mouse models and in the clinic;2. Discover and test approaches for promoting anti-tumor immunity;3. Study the mechanistic links between inflammation, immune stimulation and cancer. Since the last CCSG submission, the Programs 34 members published 539 (2006-12) cancer related papers, of which 15% were intra-programmatic and 22% inter-programmatic. The total cancer research funding of the CI Program is $16M total costs, of which $13.2IVI is peer-reviewed and $3M is NCI-funded.

Public Health Relevance

The immune system, commonly. thought of as being dedicated to fighting infection, can be directed towards killing cancer cells. On the other hand, persistent poorly controlled immune responses can promote cancer. The goal of the Cancer Immunology program is to discover ways to promote immune eradication of cancer and to prevent immune-mediated induction of cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016359-35
Application #
8755629
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
35
Fiscal Year
2014
Total Cost
$21,305
Indirect Cost
$8,509
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Wimberly, Hallie; Brown, Jason R; Schalper, Kurt et al. (2015) PD-L1 Expression Correlates with Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy in Breast Cancer. Cancer Immunol Res 3:326-32
Ma, Xiaomei; Wang, Rong; Long, Jessica B et al. (2014) The cost implications of prostate cancer screening in the Medicare population. Cancer 120:96-102
Herbst, Roy S; Soria, Jean-Charles; Kowanetz, Marcin et al. (2014) Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 515:563-7
Durazzo, Tyler S; Tigelaar, Robert E; Filler, Renata et al. (2014) Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: initiation via direct platelet signaling. Transfus Apher Sci 50:370-8
Black, Jonathan D; English, Diana P; Roque, Dana M et al. (2014) Targeted therapy in uterine serous carcinoma: an aggressive variant of endometrial cancer. Womens Health (Lond Engl) 10:45-57
Smith, Matthew R; Halabi, Susan; Ryan, Charles J et al. (2014) Randomized controlled trial of early zoledronic acid in men with castration-sensitive prostate cancer and bone metastases: results of CALGB 90202 (alliance). J Clin Oncol 32:1143-50
Cao, Jian; Liu, Zongzhi; Cheung, William K C et al. (2014) Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cell Rep 6:868-77
Gonzalez, A L; Berger, C L; Remington, J et al. (2014) Integrin-driven monocyte to dendritic cell conversion in modified extracorporeal photochemotherapy. Clin Exp Immunol 175:449-57
O'Malley, Stephanie S; Wu, Ran; Mayne, Susan T et al. (2014) Smoking cessation is followed by increases in serum bilirubin, an endogenous antioxidant associated with lower risk of lung cancer and cardiovascular disease. Nicotine Tob Res 16:1145-9
Chen, Lieping (2014) From the guest editor: Tumor site immune modulation therapy. Cancer J 20:254-5

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