The Cancer Prevention and Control Research Program (CPC) of the YCC was initiated in the mid-1980s, with the selection of Yale as one of the first two NIH-funded Cancer Prevention Research Units (CPRUs) in the United States. In 1993, Dr. Susan Mayne was appointed as Program Leader, and in 1995 she was appointed as Associate Director for Population Sciences of the Center. In 2010, Drs. Melinda Irwin and Yong Zhu were appointed co-Program Leaders, with Dr. Mayne continuing her strong leadership as Associate Director of Population Sciences. The CPC program can thematically be grouped into two primary aims ..or themes. The first theme is population-based studies of lifestyle, environmental, and molecular/genetic factors in the etiology of cancer, with a focus on cancers that have been increasing in Connecticut and elsewhere, and the second major theme is behavioral interventions in cancer prevention/control, which serves to translate findings into prevention and control across the cancer continuum, ranging from primary prevention (tobacco control, exercise, diet) through early detection message framing, to survivorship interventions and finally to end-of-life care. The program has a total of 40 program members representing 4 schools and 11 departments. CPC has a long and rich history of using the State of Connecticut as a population laboratory for cancer prevention and control research. The program is enhanced by its link to the Connecticut Tumor Registry, the oldest population-based tumor registry in the US and an NCI-funded SEER (Surveillance, Epidemiology, and End Results Program) site. In addition, researchers have access to the YCC Rapid Case Ascertainment Shared Resource (RCA), which identifies patients with newly diagnosed cancer throughout the state on a rapid basis, facilitating research projects. Some key CPC findings over the past five years include the strong impact of lifestyle factors (physical activity, diet, and weight) on cancer risk and mortality, and the biological markers/mechanisms linking lifestyle factors to cancer;various smoking cessation interventions for cancer prevention and control;the strong association between indoor tanning and basal cell carcinoma;and associations between circadian factors and several human cancers. The 40 program members have a total of $9.5M in cancer-related research grant funding (annual total costs), of which $9.3M is peer reviewed and $5.5M is NCI-funded. The program is also the host for several training programs. .Program members contributed a total of 525 publications over the last 5-year period, of which 30% are intra-programmatic and 21% are interprogrammatic.

Public Health Relevance

The Cancer Prevention and Control Research Program (CPC) is led by Drs. Melinda Irwin and Yong Zhu and has two themes: (1) population-based studies of lifestyle, environmental, and molecular/genetic factors in the etiology of cancer, and (2) behavioral interventions in cancer prevention and control.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016359-35
Application #
8755630
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
35
Fiscal Year
2014
Total Cost
$17,324
Indirect Cost
$6,919
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Yanez, Diana A; Lacher, Richard K; Vidyarthi, Aurobind et al. (2017) The role of macrophages in skin homeostasis. Pflugers Arch 469:455-463
Langdon, Casey G; Platt, James T; Means, Robert E et al. (2017) Combinatorial Screening of Pancreatic Adenocarcinoma Reveals Sensitivity to Drug Combinations Including Bromodomain Inhibitor Plus Neddylation Inhibitor. Mol Cancer Ther 16:1041-1053
Kim, Bong-Sung; Ott, Veronica; Boecker, Arne Hendrick et al. (2017) The Effect of Antiseptics on Adipose-Derived Stem Cells. Plast Reconstr Surg 139:625-637
Villarroel-Espindola, Franz; Yu, Xiaoqing; Datar, Ila et al. (2017) Spatially resolved and quantitative analysis of VISTA/PD-1H as a novel immunotherapy target in human non-small cell lung cancer. Clin Cancer Res :
Toki, Maria I; Cecchi, Fabiola; Hembrough, Todd et al. (2017) Proof of the quantitative potential of immunofluorescence by mass spectrometry. Lab Invest 97:329-334
Edelman, Martin J; Wang, Xiaofei; Hodgson, Lydia et al. (2017) Phase III Randomized, Placebo-Controlled, Double-Blind Trial of Celecoxib in Addition to Standard Chemotherapy for Advanced Non-Small-Cell Lung Cancer With Cyclooxygenase-2 Overexpression: CALGB 30801 (Alliance). J Clin Oncol 35:2184-2192
Wang, Simeng; Yang, Xiaoyong (2017) Inter-organ regulation of adipose tissue browning. Cell Mol Life Sci 74:1765-1776
Acharya, Dhiraj; Wang, Penghua; Paul, Amber M et al. (2017) Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. J Virol 91:
Swartz, Kelsey L; Wood, Scott N; Murthy, Tushar et al. (2017) E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol 37:
Menderes, Gulden; Bonazzoli, Elena; Bellone, Stefania et al. (2017) SYD985, a novel duocarmycin-based HER2-targeting antibody-drug conjugate, shows promising antitumor activity in epithelial ovarian carcinoma with HER2/Neu expression. Gynecol Oncol 146:179-186

Showing the most recent 10 out of 631 publications