Yale Pathology Tissue Services (YPTS) Shared Resource, sited in the Departs of Pathology is a longstanding shared resource providing broad tissue services to the Cancer Center and beyond. The Mission of YPTS is to provide the maximum amount and quality of human tissue for research at Yale University without impacting diagnostic quality, accuracy and safety in anatomic pathology. The service is structured into a modular architecture that integrates tissue procurement &distribution (TPD), developmental histology (DH), and clinical trials tissue services (GTTS). The TPD Module has nearly 50 standard operating procedures (SOPs) for collection of specific fresh tissue resources. About V4 of these protocols serve 12 YCC members representing about 30% of usage. The DH Module provides a range of histology services from standard tissue processing to quantitative analysis, whole slide imaging tissue microarray construction and analysis and laser capture microdissection. This facility has supported 71 YGC member users from all research programs, which represents about 29% of overall use. The GTTS module is a new addition to the resource since starting in 2010. Its function is to serve requests for tissue from cooperative group or other clinical trials that request a block or a portion of a block from the original diagnostic sample. The division reviews the original material and then ships cores of tissue blocks or recut slides to the requesting institutions. Their services are used by 6 YCC members representing about 26% of their usage. The facility is operated lead by Dr. David Rimm, assisted by Dr. Alex Vortmeyer. Each division has a technical director and there are 12 other physicians or technicians on the staff. Future plans include a move to a new larger laboratory and addition of new services included services in a CLIA certified lab and quantitative immunofluorescence services.

Public Health Relevance

Biospecimen access is a critical component of cancer research. The mission of this core is to maximize the access to biospecimens for all Yale Cancer Center users. The core both collects and processes tissue to optimize data that can be obtained from each specimen. Biospecimen collection and analysis contributes directly to the translational goals of users from nearly every program and project associated with cancer.

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National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Yale University
New Haven
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Wimberly, Hallie; Brown, Jason R; Schalper, Kurt et al. (2015) PD-L1 Expression Correlates with Tumor-Infiltrating Lymphocytes and Response to Neoadjuvant Chemotherapy in Breast Cancer. Cancer Immunol Res 3:326-32
Ma, Xiaomei; Wang, Rong; Long, Jessica B et al. (2014) The cost implications of prostate cancer screening in the Medicare population. Cancer 120:96-102
Herbst, Roy S; Soria, Jean-Charles; Kowanetz, Marcin et al. (2014) Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature 515:563-7
Durazzo, Tyler S; Tigelaar, Robert E; Filler, Renata et al. (2014) Induction of monocyte-to-dendritic cell maturation by extracorporeal photochemotherapy: initiation via direct platelet signaling. Transfus Apher Sci 50:370-8
Black, Jonathan D; English, Diana P; Roque, Dana M et al. (2014) Targeted therapy in uterine serous carcinoma: an aggressive variant of endometrial cancer. Womens Health (Lond Engl) 10:45-57
Smith, Matthew R; Halabi, Susan; Ryan, Charles J et al. (2014) Randomized controlled trial of early zoledronic acid in men with castration-sensitive prostate cancer and bone metastases: results of CALGB 90202 (alliance). J Clin Oncol 32:1143-50
Cao, Jian; Liu, Zongzhi; Cheung, William K C et al. (2014) Histone demethylase RBP2 is critical for breast cancer progression and metastasis. Cell Rep 6:868-77
Gonzalez, A L; Berger, C L; Remington, J et al. (2014) Integrin-driven monocyte to dendritic cell conversion in modified extracorporeal photochemotherapy. Clin Exp Immunol 175:449-57
O'Malley, Stephanie S; Wu, Ran; Mayne, Susan T et al. (2014) Smoking cessation is followed by increases in serum bilirubin, an endogenous antioxidant associated with lower risk of lung cancer and cardiovascular disease. Nicotine Tob Res 16:1145-9
Chen, Lieping (2014) From the guest editor: Tumor site immune modulation therapy. Cancer J 20:254-5

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