The Biostatistics Shared Resource provides support for the four broad major programmatic areas of YCC: clinical science;basic science;translational science and population science. It provides a highly interactive team of cancer biostatisticians who work collaboratively with basic, clinical, translational and population science researchers to advance the frontiers of cancer medicine and public health. The Biostatistics Shared Resource includes faculty in the Yale School of Public Health (YSPH) and staff who collaborate actively on a wide range of cancer clinical research projects and develop new methodologies related to these projects. The services provided by Biostatistics include: biostatistical support to research projects, assistance with the statistical and research aspects of new research projects and grant applications, data analysis, and training. As such, this core is vital to clinical trials/study design process. Additionally, this core has the major responsibility to support the protocol review and monitoring process of the YCC. Thus, this Shared Resource provides critical support for the complete spectrum of statistical services, from study design through the final research report writing. In January 2010, the Yale Center for Analytical Sciences (YCAS) was created in collaboration with the YSPH, Yale CTSA and Yale Cancer Center to bring all biostatistics under one umbrella. Dr. Peter Peduzzi was recruited to head the new center. Biostatistics is located with other components of YCAS, which was provided with new space 1 block from the Yale Cancer Center, Smilow Cancer Hospital and the YSPH. The co-location of Biostatistics within YCAS consolidates staff and resources for the more efficient design, conduct and analysis of cancer studies. Currently, the YCC supports partial effort for 3 faculty and 2 MS level biostatisticians. To meet anticipated demand engendered by need for YCC in investigator-initiated clinical research studies, bioinformatics, population based studies, we propose to expand this staff to include partial support for 3 additional faculty, 1 FTE additional PhD and .5 FTE in Bioinformatics support of which .3 faculty FTE and .5 staff FTE will be supported by the CCSG. In FY12, 32 YCC members from the 7 research programs accessed the Biostatistics Shared Resource, 13 of which hold peer-reviewed cancer-relevant funding. Of the nearly 4000 hours used, 22% went to protocol development (study design, sample size, analytic and monitoring plans) resulting in 14 grant submissions and 2 SPORE applications;data analysis accounted for 60% of the hours, resulting in 17 published manuscripts in 2012.

Public Health Relevance

Well-designed, executed and analyzed studies are critical to advancing the treatment and care of people with cancer. Biostatistics plays a critical role in the design, analysis and interpretation of data from these studies that help to inform treatment and prevention strategies.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Yale University
New Haven
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Yanez, Diana A; Lacher, Richard K; Vidyarthi, Aurobind et al. (2017) The role of macrophages in skin homeostasis. Pflugers Arch 469:455-463
Langdon, Casey G; Platt, James T; Means, Robert E et al. (2017) Combinatorial Screening of Pancreatic Adenocarcinoma Reveals Sensitivity to Drug Combinations Including Bromodomain Inhibitor Plus Neddylation Inhibitor. Mol Cancer Ther 16:1041-1053
Kim, Bong-Sung; Ott, Veronica; Boecker, Arne Hendrick et al. (2017) The Effect of Antiseptics on Adipose-Derived Stem Cells. Plast Reconstr Surg 139:625-637
Villarroel-Espindola, Franz; Yu, Xiaoqing; Datar, Ila et al. (2017) Spatially resolved and quantitative analysis of VISTA/PD-1H as a novel immunotherapy target in human non-small cell lung cancer. Clin Cancer Res :
Toki, Maria I; Cecchi, Fabiola; Hembrough, Todd et al. (2017) Proof of the quantitative potential of immunofluorescence by mass spectrometry. Lab Invest 97:329-334
Edelman, Martin J; Wang, Xiaofei; Hodgson, Lydia et al. (2017) Phase III Randomized, Placebo-Controlled, Double-Blind Trial of Celecoxib in Addition to Standard Chemotherapy for Advanced Non-Small-Cell Lung Cancer With Cyclooxygenase-2 Overexpression: CALGB 30801 (Alliance). J Clin Oncol 35:2184-2192
Wang, Simeng; Yang, Xiaoyong (2017) Inter-organ regulation of adipose tissue browning. Cell Mol Life Sci 74:1765-1776
Acharya, Dhiraj; Wang, Penghua; Paul, Amber M et al. (2017) Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. J Virol 91:
Swartz, Kelsey L; Wood, Scott N; Murthy, Tushar et al. (2017) E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol 37:
Menderes, Gulden; Bonazzoli, Elena; Bellone, Stefania et al. (2017) SYD985, a novel duocarmycin-based HER2-targeting antibody-drug conjugate, shows promising antitumor activity in epithelial ovarian carcinoma with HER2/Neu expression. Gynecol Oncol 146:179-186

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