CANCERPREVENTIONANDCONTROLRESEARCHPROGRAM PROGRAMCODE:CPC PROJECTSUMMARY/ABSTRACT ThemissionofCPCistopreventandcontrolcancerbyidentifyingfactorsthatcontributetocancer developmentandoutcomes,andconductinginterventionstoaddressthesefactors.
The SpecificAims ofour programareto:1)identifylifestyle,environmental,andgeneticriskfactorsintheetiologyofcancer;?2)assess thepatternsofcarereceivedbypatientswithcancertoidentifyeffectivestrategiestoimprovepatient outcomes,and3)conductandevaluatelifestylebehavioralinterventionsforcancerpreventionandcontrol. Dr.MelindaIrwinisAssociateDirectorforPopulationSciencesandco-leadstheCPCprogramalongwithDr. XiaomeiMa.Dr.Irwin?sexpertiseisinlifestylebehavioralinterventions,sosheoverseesresearchrelatedto Aim3.Dr.Ma?sexpertiseisinetiologyandoutcomes,sosheoverseesCPCresearchrelatedtoAims1and2. Together,Drs.IrwinandMafacilitatethecollaborationofCPCmemberswithmembersfromotherresearch programsanddisease-alignedresearchteams(DARTs)withthegoalofstimulatingtransdisciplinaryresearch thatwillimpactcancerriskandmortalityrateswithinandbeyondthestateofConnecticut. Currently,thereare38CPCmembers,withprimaryappointmentsin11departmentsandthreeschools.Our cancer-relatedfunding(directcostonly)hasincreased5%from$6.4Minthepreviouscycleto$6.7Minthe currentcycle,ofwhich$5.6M(84%)waspeerreviewedand$2.5MwasfromNCI.Ofthe793cancer-related publicationsbyCPCmembersfromJuly2012toJune2017(with30%and24%involvingintra-andinter- collaborations),manyhavehadamajorimpactonclinicaland/orpublichealthpractice.Drs.GrossandYu?s (RadiobiologyandRadiotherapy[RR]program)findingsofearlytoxicityfromprotonbeamtherapyforprostate cancerwascitedinthedecisionbyBlueShieldofCaliforniatostopreimbursingprotonbeamtherapyfor prostatecancer.Dr.Niccolai?sHPVvaccinationresearchhasimprovedvaccinationratesandhaslocal,state, andnationalimpact.Drs.Irwin,Sanft,Cartmel,andChagpar?swork,showingbenefitsofexerciseandweight lossoncancerbiomarkersandtreatment-relatedsideeffects,ischangingcancercaredeliverywith implementationoflifestyle/behaviorcounselingintheclinic. YCCandCPCleadershiphavedevelopedastrategicplantoguideourfutureinitiatives,withtheprimarygoal ofaddingdepthandbreadthtoourexistingstrengthsincanceroutcomesandlifestyle/behavioralresearch. Goalswithinthenextfiveyearsincluderecruitmentofadditionalfacultyincanceroutcomesanddissemination andimplementationresearch;?thesubmissionofaP01focusedonrandomizedtrialsofenergybalancein cancersurvivors;?twoT32applicationson1)obesityresearchand2)canceretiology,outcomesand survivorshipresearch;?andparticipatinginsubmissionofmoreSPOREapplicationswithCPCmembers leadingprojects.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016359-39
Application #
9570289
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-08-01
Budget End
2019-07-31
Support Year
39
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Kim, Bong-Sung; Ott, Veronica; Boecker, Arne Hendrick et al. (2017) The Effect of Antiseptics on Adipose-Derived Stem Cells. Plast Reconstr Surg 139:625-637
Yanez, Diana A; Lacher, Richard K; Vidyarthi, Aurobind et al. (2017) The role of macrophages in skin homeostasis. Pflugers Arch 469:455-463
Langdon, Casey G; Platt, James T; Means, Robert E et al. (2017) Combinatorial Screening of Pancreatic Adenocarcinoma Reveals Sensitivity to Drug Combinations Including Bromodomain Inhibitor Plus Neddylation Inhibitor. Mol Cancer Ther 16:1041-1053
Edelman, Martin J; Wang, Xiaofei; Hodgson, Lydia et al. (2017) Phase III Randomized, Placebo-Controlled, Double-Blind Trial of Celecoxib in Addition to Standard Chemotherapy for Advanced Non-Small-Cell Lung Cancer With Cyclooxygenase-2 Overexpression: CALGB 30801 (Alliance). J Clin Oncol 35:2184-2192
Villarroel-Espindola, Franz; Yu, Xiaoqing; Datar, Ila et al. (2017) Spatially resolved and quantitative analysis of VISTA/PD-1H as a novel immunotherapy target in human non-small cell lung cancer. Clin Cancer Res :
Toki, Maria I; Cecchi, Fabiola; Hembrough, Todd et al. (2017) Proof of the quantitative potential of immunofluorescence by mass spectrometry. Lab Invest 97:329-334
Swartz, Kelsey L; Wood, Scott N; Murthy, Tushar et al. (2017) E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts. Mol Cell Biol 37:
Wang, Simeng; Yang, Xiaoyong (2017) Inter-organ regulation of adipose tissue browning. Cell Mol Life Sci 74:1765-1776
Acharya, Dhiraj; Wang, Penghua; Paul, Amber M et al. (2017) Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. J Virol 91:
Brechbuhl, Heather M; Finlay-Schultz, Jessica; Yamamoto, Tomomi M et al. (2017) Fibroblast Subtypes Regulate Responsiveness of Luminal Breast Cancer to Estrogen. Clin Cancer Res 23:1710-1721

Showing the most recent 10 out of 631 publications