The Flow Cytometry and Cell Sorting Facility was created by the ACC in 1980, and has been continuously approved and funded by the NCI Core Support Grant since 1981. In the last competitive renewal, this shared resource received an "outstanding merit" evaluation. Jonni Moore, Ph.D., Professor of Pathology and Laboratory Medicine, has directed the Facility since 1990. She has a doctorate in immunology with over 25 years of flow cytometry experience and frequently serves as an expert consultant to industry and academia. Charies Pletcher, MCI, Technical Director, has been with the Facility since 1987. The laboratory has remained committed to its mission of providing all investigators at the University of Pennsylvania with access to high quality, cost effective services, as well as the scientific expertise necessary to use this technology in their research efforts. This facility is currently recognized as one of the largest and most comprehensive academic flow cytometry shared resources in the United States, offering access to a broad range of analytical and sorting cytometers, expert consultation and an extensive educational program. During the current project period, the Flow Cytometry and Cell Sorting Facility has remained the most frequently used shared resource of the Abramson Cancer Center and has continued to experience growth. Overall usage has increased by 63% (based on usage hours) during the current project period. Over 100 ACC members have used the facility in the past year, with 54% of total usage by ACC members. CCSG support represents 16% of the proposed facility budget with the remaining funding coming from charge backs and institutional support. The success of the core has been facilitated by the addition of instrumentation, recruitment of staff, expansion of training programs and the increased interest in cytomics within the ACC membership.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016520-38
Application #
8593266
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
38
Fiscal Year
2014
Total Cost
$233,418
Indirect Cost
$86,401
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Qin, Jie; Rajaratnam, Rajathees; Feng, Li et al. (2015) Development of organometallic S6K1 inhibitors. J Med Chem 58:305-14
Couch, Fergus J; Nathanson, Katherine L; Offit, Kenneth (2014) Two decades after BRCA: setting paradigms in personalized cancer care and prevention. Science 343:1466-70
Maus, Marcela V; June, Carl H (2014) CARTs on the road for myeloma. Clin Cancer Res 20:3899-901
Al Zaki, Ajlan; Joh, Daniel; Cheng, Zhiliang et al. (2014) Gold-loaded polymeric micelles for computed tomography-guided radiation therapy treatment and radiosensitization. ACS Nano 8:104-12
Noti, Mario; Kim, Brian S; Siracusa, Mark C et al. (2014) Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin-basophil axis. J Allergy Clin Immunol 133:1390-9, 1399.e1-6
Rosenfeld, Myrna R; Ye, Xiaobu; Supko, Jeffrey G et al. (2014) A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme. Autophagy 10:1359-68
Mays, Lauren E; Wang, Lili; Lin, Jianping et al. (2014) AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells. Mol Ther 22:28-41
Zhang, Liming; Zhu, Caixia; Guo, Yi et al. (2014) Inhibition of KAP1 enhances hypoxia-induced Kaposi's sarcoma-associated herpesvirus reactivation through RBP-J?. J Virol 88:6873-84
Bhattacharya, Sabyasachi; Katlinski, Kanstantsin V; Reichert, Maximilian et al. (2014) Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury. EMBO Mol Med 6:384-97
Zhang, Pingfeng; Leu, Julia I-Ju; Murphy, Maureen E et al. (2014) Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate. PLoS One 9:e103518

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