The Pediatric Oncology Program has been continuously approved in the NCI Cancer Center Support Grant since 1992. The mission of the Program is to discover and develop targeted, rational treatment approaches to improve cure rates and reduce acute and long-term toxicities in children with cancer. The Programmatic goals are: 1) to define the genetic and cellular alterations involved in the pathogenesis of childhood cancers and to translate these discoveries into new diagnostics, biomarkers and therapeutic targets; 2) to develop and clinically test new immunotherapies that target tumor-specific antigens on childhood cancers; 3) to improve outcomes for childhood cancers by designing and conducting clinical trials of biologically targeted therapies, and by developing more rational methods of administering conventional therapies using pharmacokinetics and pharmacoepidemiology; and 4) to develop approaches to minimize the acute and long-term adverse effects of cancer treatment in children and adolescents using an integrated research approach incorporating psychosocial, survivorship and cancer control outcome measures. This Program was rated as ?Outstanding to Exceptional? at the time of the 2010 CCSG renewal application and is led by Frank Balis, MD, Professor of Pediatrics and Director of Clinical Cancer Research and Garrett Brodeur, MD, Professor of Pediatrics and Associate Director for Pediatric Research at the Abramson Cancer Center. Drs. Balis and Brodeur are experienced researchers and national leaders in childhood cancer research. The Pediatric Oncology Program has fully integrated basic, translational, and clinical research components, with a diverse group of investigators who have expertise and research efforts in cancer genomics, cell biology and signal transduction, tumor immunology and immunotherapy, drug development, clinical pharmacology, epidemiology, clinical research, cancer control, survivorship, and behavioral oncology. The Program is fully integrated into the Cancer Center. Pediatric oncologists are members of four other Programs, and Program members collaborate with investigators from five of the other Programs. The Pediatric Oncology Program is an international leader in clinical research and serves as the lead institution for the COG NCI Chair's grant. The 35 Program members represent five departments in the Perelman School of Medicine and have $16M in annual research grant funding, of which $6.4M is peer-reviewed and $2M is NCI-funded. There have been a total of 443 cancer- related publications from the Program since 2010. Of these, 35% are intra-Programmatic, 14% resulted from inter-Programmatic collaboration, and 71% are multi-institutional.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016520-42
Application #
9535728
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Marino, Michael A
Project Start
Project End
Budget Start
2017-12-01
Budget End
2018-11-30
Support Year
42
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Till, Jacob E; Yoon, Changhwan; Kim, Bang-Jin et al. (2017) Oncogenic KRAS and p53 Loss Drive Gastric Tumorigenesis in Mice That Can Be Attenuated by E-Cadherin Expression. Cancer Res 77:5349-5359
Taylor, Laura A; Abraham, Ronnie M; Tahirovic, Emin et al. (2017) High ALDH1 expression correlates with better prognosis in tumorigenic malignant melanoma. Mod Pathol 30:634-639
Rebecca, Vito W; Nicastri, Michael C; McLaughlin, Noel et al. (2017) A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. Cancer Discov 7:1266-1283
Zang, Tianzhu; Taplin, Mary-Ellen; Tamae, Daniel et al. (2017) Testicular vs adrenal sources of hydroxy-androgens in prostate cancer. Endocr Relat Cancer 24:393-404
Ewens, Kathryn G; Bhatti, Tricia R; Moran, Kimberly A et al. (2017) Phosphorylation of pRb: mechanism for RB pathway inactivation in MYCN-amplified retinoblastoma. Cancer Med 6:619-630
Chee, Wonshik; Lee, Yaelim; Im, Eun-Ok et al. (2017) A culturally tailored Internet cancer support group for Asian American breast cancer survivors: A randomized controlled pilot intervention study. J Telemed Telecare 23:618-626
Fennelly, Colin; Amaravadi, Ravi K (2017) Lysosomal Biology in Cancer. Methods Mol Biol 1594:293-308
Walter, David M; Venancio, Olivia S; Buza, Elizabeth L et al. (2017) Systematic In Vivo Inactivation of Chromatin-Regulating Enzymes Identifies Setd2 as a Potent Tumor Suppressor in Lung Adenocarcinoma. Cancer Res 77:1719-1729
Carrer, Alessandro; Parris, Joshua L D; Trefely, Sophie et al. (2017) Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels. J Biol Chem 292:3312-3322
Tasian, Sarah K; Kenderian, Saad S; Shen, Feng et al. (2017) Optimized depletion of chimeric antigen receptor T cells in murine xenograft models of human acute myeloid leukemia. Blood 129:2395-2407

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