The High Resolution Electron Microscopy Facility (HREMF) was established in 1997 to provide a resource to investigators for high resolution imaging of cells, tissues, and nanomateriais. The mission of the HREMF is to provide scanning and transmission electron microscopy services to members of MD Anderson. The HREMF occupies 536 square feet in the R.E. """"""""Bob"""""""" Smith Research Building on the South Campus. The HREMF offers a number of services including: (a) consultation and assistance in constructing appropriate experimental designs for scanning electron microscopy (SEM) and transmission electron microscopy (TEM), (b) processing of samples for SEM and TEM, (c) assistance with sample screening and data interpretation, (d) recommendations for future experiments, and (e) assistance with the development of custom designed protocols to meet individual investigator needs. The HREMF houses 2 electron microscopes: a Joel JEM1010 TEM and a Joel JEM5900 SEM. Additional equipment needed to prepare samples for TEM and SEM, such as an ultramicrotome and ultrastainer, are also maintained in the facility. The JEM5900 SEM is equipped with an electron backscatter detector and is the only microscope of its kind available on the MD Anderson campus. Similarly, the TEM is the only such instrument at MD Anderson dedicated solely for research. The institution recognizes the importance of the HREMF to MD Anderson members and recently purchased software packages that enhance the performance and capabilities of the electron microscopes. Over the past 5 years, the HREMF provided services to 141 investigators, a 58% increase over the 2002- 2007 period. Sixty-four percent of users of the resource were MD Anderson members with peer-reviewed funding, and 55% of the total budget is requested from the CCSG. Publications cited using the HREMF have appeared in Proc Nat Acad Sci and J Natl Cancer Inst. Several of these reports focused on the development of novel therapeutic strategies to treat chemotherapy resistant tumors, such as the use of nanoparticle mediated hyperthermia therapy for the treatment of pancreatic cancer. The HREMF has supported these innovative approaches by helping Investigators characterize the bioengineered material. In future work, HREMF will develop new approaches to facilitate studies seeking to use nanomateriais for therapeutic and diagnostic applications. The HREMF plans to continue adopting and developing new electron microscopy techniques to assist investigators with their studies. The HREMF requests 55% of the total operating budget from CCSG funding.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA016672-38
Application #
8557377
Study Section
Subcommittee G - Education (NCI)
Project Start
1998-09-04
Project End
2018-06-30
Budget Start
2013-09-06
Budget End
2014-06-30
Support Year
38
Fiscal Year
2013
Total Cost
$124,144
Indirect Cost
$46,569
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Van Roosbroeck, Katrien; Fanini, Francesca; Setoyama, Tetsuro et al. (2016) Combining anti-miR-155 with chemotherapy for the treatment of lung cancers. Clin Cancer Res :
Cassani, Lisa S; Raju, Gottumukkala S (2016) Techniques for management of bleeding associated with colonic endoscopic mucosal resection. Gastrointest Endosc 83:469-70
Zargar, Homayoun; Atwell, Thomas D; Cadeddu, Jeffrey A et al. (2016) Cryoablation for Small Renal Masses: Selection Criteria, Complications, and Functional and Oncologic Results. Eur Urol 69:116-28
Ma, Junsheng; Hobbs, Brian P; Stingo, Francesco C (2016) Integrating genomic signatures for treatment selection with Bayesian predictive failure time models. Stat Methods Med Res :
Jinesh, Goodwin G; Kamat, Ashish M (2016) Endocytosis and serpentine filopodia drive blebbishield-mediated resurrection of apoptotic cancer stem cells. Cell Death Discov 2:
Maiti, Abhishek; Cortes, Jorge E; Brown, Yolanda D et al. (2016) Phase I/II study of low-dose azacytidine in patients with chronic myeloid leukemia who have minimal residual disease while receiving therapy with tyrosine kinase inhibitors. Leuk Lymphoma :1-4
Visone, R; Pallante, P; Vecchione, A et al. (2016) Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. Oncogene 35:5214
Zhou, Fuling; Li, Ming; Wei, Yongchang et al. (2016) Activation of HERV-K Env protein is essential for tumorigenesis and metastasis of breast cancer cells. Oncotarget :
Gamaletsou, Maria N; Rammaert, Blandine; Bueno, Marimelle A et al. (2016) Candida Arthritis: Analysis of 112 Pediatric and Adult Cases. Open Forum Infect Dis 3:ofv207
Parra, Edwin R; Behrens, Carmen; Rodriguez-Canales, Jaime et al. (2016) Image Analysis-based Assessment of PD-L1 and Tumor-Associated Immune Cells Density Supports Distinct Intratumoral Microenvironment Groups in Non-small Cell Lung Carcinoma Patients. Clin Cancer Res :

Showing the most recent 10 out of 9121 publications