The Bioinformatics Shared Resource (BISR) provides consultation, collaboration, and support for researchers and core facilities throughout MD Anderson in the statistical analysis and biological interpretation of data from high-throughput pre-clinical technologies. The BISIR has specialist expertise in the bioinformatics of all types of microarrays, next-generation sequencing, mass spectrometry, and flow cytometry. The consultation and collaboration services of the BISR (in hours) have grown 3.1 fold over the past 5 years. The BISR uses a heterogeneous computing environment supported across Windows, Unix/Linux, and Mac OS X operating systems, with access to more than 300 terabytes of in-house storage space for home directories, research data, and data mirrors. It accesses in-house parallel computing capability through a 48-processor Cray XD1 HPC cluster and a 290-processor distributed computing Condor pool of over 160 Windows workstations (each with >2GB of memory) and 8 servers (ranging from 4GB to 16GB of memory). BISR services have been used over the past 5 years by 301 researchers 92% of whom are peer-reviewed cancer center members. Publications cited using the BISR have appeared in Nature, Science, N Engl J Med and J Clin Oncol. Annually, MD Anderson has provided institutional support to the BISR in the amount of $1,244,846. The BISR is requesting funding from the CCSG in the amount of 3% of its total operating budget. In the last 5 years, the BISR has (1) recruited 9 very strong new faculty members from top institutions plus 2 more with joint appointments. It will continue to recruit top bioinformatics faculty and will encourage their participation in multidisciplinary collaborative research to complement their investigator-initiated research;(2) recruited 8 new statistical analysts and 3 biocatalysts to support projects around the institution;(3) created a cadre of 14 postdoctoral fellows, who participate in collaborative research;(4) recruited 4 new programmer/software engineers plus 6 on contract to provide programming strength for its support functions. It will continue to seek talented computer specialists;(5) established a popular hands-on workshop series on bioinformatics tools for MD Anderson biologists and clinical researchers (>500 attendees for 2-hour sessions to date). The BISR will continue to encourage the professional growth of ail of its members through advanced education In bioinformatics and computational skills. It will continue to improve its emerging status as one of the world?s leading bioinformatics groups as we pursue MD Anderson's mission: Making cancer history.
It is now easier, and often cheaper, to generate millions of data points on the molecular profiles of cancers than it is to analyze those data points statistically or interpret them biologically. With the revolution in DNA and RNA sequencing, the need for bioinformatics support throughout MD Anderson has increased exponentially, and the BISR is the institution?s principal resource for dealing with this data deluge.
|Yedururi, Sireesha; Terpenning, Silanath; Gupta, Sanjay et al. (2017) Radiofrequency Ablation of Hepatic Tumor: Subjective Assessment of the Perilesional Vascular Network on Contrast-Enhanced Computed Tomography Before and After Ablation Can Reliably Predict the Risk of Local Recurrence. J Comput Assist Tomogr 41:607-613|
|Montalban-Bravo, G; Huang, X; Jabbour, E et al. (2017) A clinical trial for patients with acute myeloid leukemia or myelodysplastic syndromes not eligible for standard clinical trials. Leukemia 31:318-324|
|Tadros, Audree B; Smith, Benjamin D; Shen, Yu et al. (2017) Ductal Carcinoma In Situ and Margins <2?mm: Contemporary Outcomes With Breast Conservation. Ann Surg :|
|Ikoma, Naruhiko; Raghav, Kanwal; Chang, George (2017) An Update on Randomized Clinical Trials in Metastatic Colorectal Carcinoma. Surg Oncol Clin N Am 26:667-687|
|Alhuraiji, Ahmad; Jain, Nitin (2017) Immunofluorescence staining with an antipromyelocytic leukemia antibody for a rapid diagnosis of acute promyelocytic leukemia. Hematol Oncol Stem Cell Ther 10:33-34|
|Lin, Heather Y; Bedrosian, Isabelle; Babiera, Gildy V et al. (2017) Using the National Cancer Data Base for quality evaluation to assess adherence to treatment guidelines for nonmetastatic inflammatory breast cancer. Cancer 123:2618-2625|
|Rozovski, Uri; Harris, David M; Li, Ping et al. (2017) Constitutive Phosphorylation of STAT3 by the CK2-BLNK-CD5 Complex. Mol Cancer Res 15:610-618|
|Masarova, Lucia; Kantarjian, Hagop; Garcia-Mannero, Guillermo et al. (2017) Harnessing the Immune System Against Leukemia: Monoclonal Antibodies and Checkpoint Strategies for AML. Adv Exp Med Biol 995:73-95|
|Palacios, Cristina; Daniel, Carrie R; Tirado-Gómez, Maribel et al. (2017) Dietary Patterns in Puerto Rican and Mexican-American Breast Cancer Survivors: A Pilot Study. J Immigr Minor Health 19:341-348|
|Gunther, Jillian R; Chadha, Awalpreet S; Shin, Ui Sup et al. (2017) Preoperative radiation dose escalation for rectal cancer using a concomitant boost strategy improves tumor downstaging without increasing toxicity: A matched-pair analysis. Adv Radiat Oncol 2:455-464|
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