The Small Animal Imaging Facility (SAIF) provides Cancer Center Members with powerful imaging technologies, staff and expertise necessary to integrate imaging into preclinical cancer research. The facility is led by Drs. John D. Hazle and James A. Bankson and is supported by a network of faculty with research expertise in each imaging modality. Faculty and staff consult with users prior to planning of imaging experiments, and assist in all aspects of imaging services, including preparation of grants, experimental design, protocol optimization, data acquisition and analysis, interpretation, presentation, and publication of results. Instrumentation and full-service support are available for preclinical MRI (4.7T/40cm, 7.0T/30cm) including hyperpolarized """"""""C-labeled tracers (such as [1-^^C]-pyruvate), x-ray computed tomography (in-vivo and specimen), micro-ultrasound, digital planar x-ray, nuclear imaging using PET, SPECT, and gamma camera, and optical (bioluminescence/fluorescence) imaging. More than $2.5M of institutional support allowed for upgrade, expansion, or addition of significant new services in ultrasound, optical, and MR imaging, hyperpolarized tracers, and image-guided radiation therapy. A modest 6.3% growth in overall utilization by hours during this period belies a continually expanding base of users supported by federal funding. 118 distinct principal investigators affiliated with 19 CCSG Programs made use of SAIF resources during this funding period. Peer-reviewed investigators account for 89% of the utilization, and 24% of the total costs are requested from the CCSG. Overall, the number of federally funded investigators making use of SAIF resources grew by more than 275% compared to the prior period. The requested CCSG support for these services corresponds to 24% of the projected operating budget. Publications cited using the SAIF have appeared in Proc Natl Acad Sci and J Natl Cancer Inst. In the forthcoming period, new satellite facilities in the South Campus Vivarium and the Center for Advanced Biomedical Imaging Research will be added, and new services will be offered in image-guided radiation therapy and metabolic imaging using hyperpolarized tracers.

Public Health Relevance

The Small Animal Imaging Facility provides access to imaging instrumentation and expertise that allows Cancer Center Members to integrate powerful and cutting-edge imaging technologies into routine preclinical research with confidence that their scientific objectives will be achieved. The SAIF has also developed a new multi-animal imaging platform to reduce the cost of imaging in small animal research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA016672-39
Application #
8759773
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
39
Fiscal Year
2014
Total Cost
$235,740
Indirect Cost
$88,465
Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Torres, Harrys A; Hosry, Jeff; Mahale, Parag et al. (2018) Hepatitis C virus reactivation in patients receiving cancer treatment: A prospective observational study. Hepatology 67:36-47
Parra, Edwin R; Villalobos, Pamela; Behrens, Carmen et al. (2018) Effect of neoadjuvant chemotherapy on the immune microenvironment in non-small cell lung carcinomas as determined by multiplex immunofluorescence and image analysis approaches. J Immunother Cancer 6:48
Yin, Guosheng; Chen, Nan; Lee, J Jack (2018) Bayesian Adaptive Randomization and Trial Monitoring with Predictive Probability for Time-to-event Endpoint. Stat Biosci 10:420-438
Nong, Jingying; Gong, Yuhua; Guan, Yanfang et al. (2018) Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer. Nat Commun 9:3114
Brown, Justin C; Rickels, Michael R; Troxel, Andrea B et al. (2018) Dose-response effects of exercise on insulin among colon cancer survivors. Endocr Relat Cancer 25:11-19
Vakil, Erik; Jimenez, Carlos A; Faiz, Saadia A (2018) Pleural effusions in hematologic malignancies and their management with indwelling pleural catheters. Curr Opin Pulm Med 24:384-391
Yedururi, Sireesha; Chawla, Sumedha; Amini, Behrang et al. (2018) Tumor thrombus in the large veins draining primary pelvic osteosarcoma on cross sectional imaging. Eur J Radiol 105:49-55
Farinholt, Paige; Park, Minjeong; Guo, Ying et al. (2018) A Comparison of the Accuracy of Clinician Prediction of Survival Versus the Palliative Prognostic Index. J Pain Symptom Manage 55:792-797
Oh, Sang Cheul; Sohn, Bo Hwa; Cheong, Jae-Ho et al. (2018) Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. Nat Commun 9:1777
Yang, Yi; Li, Chia-Wei; Chan, Li-Chuan et al. (2018) Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth. Cell Res 28:862-864

Showing the most recent 10 out of 12418 publications