The Biostatistics Shared Resource (BSR) supports the research of 43% (n=62/144) of all program-aligned members of the St. Jude Comprehensive Cancer Center (SJCCC), of which 61% (n=38/62) have cancer related peer-reviewed funding, and 39% (n=24/62) hold cancer-related, non-peer-reviewed funding. These SJCCC members were drawn from all five of our Center Programs. The resource provides collaborative, statistical support to Center members for peer-reviewed, funded grants and statistical designs for institutional clinical, translational and pre-clinical studies, as well as for laboratory investigations. BSR biostatisticians are active members of SJCCC Programs and provide members with access to state-of-the-art, innovative statistical science;a centralized randomization system;access to SAS for Windows;technical support for a web-based distributed data management system. The Cancer Center Support Grant provides critical funding that is necessary to ensure centralization of function and stability of support;thus, permitting cost effective, timely collaborations.

Public Health Relevance

The Biostatistics Shared Resource provides the SJCCC with outstanding support for the appropriate statistical design and analysis of both clinical and laboratory cancer research. The input of this resource is critical to ensure that all study objectives are addressed with statistical confidence and subsequent publications are supported by appropriate statistical analyses providing valid inferences.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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St. Jude Children's Research Hospital
United States
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Wu, Jianrong (2015) Power and sample size for randomized phase III survival trials under the Weibull model. J Biopharm Stat 25:16-28
Serinagaoglu, Yelda; Paré, Joshua; Giovannini, Marco et al. (2015) Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev Biol 398:97-109
Kimberg, Cara I; Klosky, James L; Zhang, Nan et al. (2015) Predictors of health care utilization in adult survivors of childhood cancer exposed to central nervous system-directed therapy. Cancer 121:774-82
Bhojwani, Deepa; McCarville, Mary B; Choi, John K et al. (2015) The role of FDG-PET/CT in the evaluation of residual disease in paediatric non-Hodgkin lymphoma. Br J Haematol 168:845-53
Chamdine, Omar; Gaur, Aditya H; Broniscer, Alberto (2015) Effective treatment of cerebral mucormycosis associated with brain surgery. Pediatr Infect Dis J 34:542-3
Karol, Seth E; Coustan-Smith, Elaine; Cao, Xueyuan et al. (2015) Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy. Br J Haematol 168:94-101
Chan, W K; Suwannasaen, D; Throm, R E et al. (2015) Chimeric antigen receptor-redirected CD45RA-negative T cells have potent antileukemia and pathogen memory response without graft-versus-host activity. Leukemia 29:387-95
Gawade, Prasad L; Oeffinger, Kevin C; Sklar, Charles A et al. (2015) Lifestyle, distress, and pregnancy outcomes in the Childhood Cancer Survivor Study cohort. Am J Obstet Gynecol 212:47.e1-10
Momani, Tha'er G; Mandrell, Belinda N; Gattuso, Jami S et al. (2015) Children's perspective on health-related quality of life during active treatment for acute lymphoblastic leukemia: an advanced content analysis approach. Cancer Nurs 38:49-58
Dodd, K; Nance, S; Quezada, M et al. (2015) Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity. Oncogene 34:1312-22

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