The Biostatistics Shared Resource (BSR) supports the research of 43% (n=62/144) of all program-aligned members of the St. Jude Comprehensive Cancer Center (SJCCC), of which 61% (n=38/62) have cancer related peer-reviewed funding, and 39% (n=24/62) hold cancer-related, non-peer-reviewed funding. These SJCCC members were drawn from all five of our Center Programs. The resource provides collaborative, statistical support to Center members for peer-reviewed, funded grants and statistical designs for institutional clinical, translational and pre-clinical studies, as well as for laboratory investigations. BSR biostatisticians are active members of SJCCC Programs and provide members with access to state-of-the-art, innovative statistical science;a centralized randomization system;access to SAS for Windows;technical support for a web-based distributed data management system. The Cancer Center Support Grant provides critical funding that is necessary to ensure centralization of function and stability of support;thus, permitting cost effective, timely collaborations.
The Biostatistics Shared Resource provides the SJCCC with outstanding support for the appropriate statistical design and analysis of both clinical and laboratory cancer research. The input of this resource is critical to ensure that all study objectives are addressed with statistical confidence and subsequent publications are supported by appropriate statistical analyses providing valid inferences.
|ElInati, Elias; Russell, Helen R; Ojarikre, Obah A et al. (2017) DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line. Proc Natl Acad Sci U S A 114:12536-12541|
|Gibson, Todd M; Li, Zhenghong; Green, Daniel M et al. (2017) Blood Pressure Status in Adult Survivors of Childhood Cancer: A Report from the St. Jude Lifetime Cohort Study. Cancer Epidemiol Biomarkers Prev 26:1705-1713|
|Scott, Daniel C; Hammill, Jared T; Min, Jaeki et al. (2017) Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. Nat Chem Biol 13:850-857|
|Patel, Y T; Daryani, V M; Patel, P et al. (2017) Population Pharmacokinetics of Selumetinib and Its Metabolite N-desmethyl-selumetinib in Adult Patients With Advanced Solid Tumors and Children With Low-Grade Gliomas. CPT Pharmacometrics Syst Pharmacol 6:305-314|
|Penkert, Rhiannon R; Jones, Bart G; Häcker, Hans et al. (2017) Vitamin A differentially regulates cytokine expression in respiratory epithelial and macrophage cell lines. Cytokine 91:1-5|
|Howell, Carrie R; Wilson, Carmen L; Ehrhardt, Matthew J et al. (2017) Clinical impact of sedentary behaviors in adult survivors of acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort study. Cancer :|
|Talleur, Aimee C; Triplett, Brandon M; Federico, Sara et al. (2017) Consolidation Therapy for Newly Diagnosed Pediatric Patients with High-Risk Neuroblastoma Using Busulfan/Melphalan, Autologous Hematopoietic Cell Transplantation, Anti-GD2 Antibody, Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-2, and Hapl Biol Blood Marrow Transplant 23:1910-1917|
|Wu, Jianrong (2017) Single-Arm Phase II Survival Trial Design Under the Proportional Hazards Model. Stat Biopharm Res 9:25-34|
|Svolos, P; Reddick, W E; Edwards, A et al. (2017) Measurable Supratentorial White Matter Volume Changes in Patients with Diffuse Intrinsic Pontine Glioma Treated with an Anti-Vascular Endothelial Growth Factor Agent, Steroids, and Radiation. AJNR Am J Neuroradiol 38:1235-1241|
|Lin, Wenwei; Goktug, Asli N; Wu, Jing et al. (2017) High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor. Assay Drug Dev Technol 15:383-394|
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