?Cancer Control and Survivorship Program The overarching goal of the Cancer Control and Survivorship Program (CCSP) is to conduct highly innovative clinical, genetic, and observational research, and translate our findings into effective strategies to avert or mitigate treatment-related complications and improve the quality of life of childhood cancer survivors. Drs. Leslie L. Robison, chair of the Department of Epidemiology and Cancer Control, and Melissa Hudson, director of the Division of Cancer Survivorship, lead the Program. Their leadership roles in the CCSP's two NCI-funded cohorts, St. Jude Lifetime Cohort Study (SJLIFE) and the Childhood Cancer Survivor Study (CCSS), have facilitated seminal discoveries characterizing the magnitude and scope of morbidity of the childhood cancer experience, including the resulting burden of chronic disease and subsequent neoplasms and their contribution to premature mortality. Knowledge gained from this research has influenced the design of contemporary pediatric cancer treatment strategies and provided critical data to guide health surveillance and health preserving interventions for long-term survivors. The CCSP is structured around an extensive shared research infrastructure designed to support and enhance the research conducted by Program members. This infrastructure reflects a combination of departmental-focused resources, augmented by institutional and SJCCC-specific resources plus clinical services external to the institution. The CCSP has a total of 16 members (11 Full and 5 Associate), representing the Departments of Epidemiology & Cancer Control, Oncology, Psychology, Global Pediatric Medicine, and Pediatric Medicine. The design and conduct of innovative research is facilitated by 7 discipline-specific CCSP working groups: Neurosciences, Cardiopulmonary, Endocrine-Reproductive, Genetics, Global Outcomes, Psychosocial-Behavioral, and Epidemiology-Biostatistics, who meet on a regular schedule (bi-weekly or monthly). During the current grant period (2013-2017), CCSP members have actively engaged in intra- and inter- programmatic research collaborations. Research publications by CCSP members totaled 424 and demonstrate the highly collaborative nature of the Program with 50% reflecting an intra-programmatic and 25.9% inter- programmatic collaboration. During the current funding period, CCSP members initiated/conducted trials addressing approaches to enhance health screening for at-risk survivors, promote positive health behaviors, remediate treatment-induced cognitive deficits, and reduce fatigue, contributing a total of 2283 enrollments to interventional non-therapeutic trials. Many of these trials reflect a direct translation of observational research conducted by CCSP members. CCSP members have participated in a wide variety of multi-group collaborations (involving more than 20 NCI-designated Cancer Centers, the NCI Division of Cancer Epidemiology and Genetics, the Children's Oncology Group, and multiple international centers) to characterize treatment and genetic factors conferring high risk for specific late effects. CCSP members have a total of $4.2M in annual peer-reviewed funding, including $4.1M in NCI funding.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA021765-40
Application #
9632014
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-03-01
Budget End
2020-02-29
Support Year
40
Fiscal Year
2019
Total Cost
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Zheng, Daniel J; Krull, Kevin R; Chen, Yan et al. (2018) Long-term psychological and educational outcomes for survivors of neuroblastoma: A report from the Childhood Cancer Survivor Study. Cancer 124:3220-3230
Fatima, Soghra; Zhou, Sheng; Sorrentino, Brian P (2018) Marking of definitive HSC precursors in E7.5-E8.5 embryos using an Abcg2-CreER lineage-tracing mouse model. Exp Hematol 65:29-33
Chen, Wenan; Li, Yan; Easton, John et al. (2018) UMI-count modeling and differential expression analysis for single-cell RNA sequencing. Genome Biol 19:70
Snaman, J M; Talleur, A C; Lu, J et al. (2018) Treatment intensity and symptom burden in hospitalized adolescent and young adult hematopoietic cell transplant recipients at the end of life. Bone Marrow Transplant 53:84-90
Robinson, Giles W; Rudneva, Vasilisa A; Buchhalter, Ivo et al. (2018) Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial. Lancet Oncol 19:768-784
Creutzig, Ursula; Kutny, Matthew A; Barr, Ronald et al. (2018) Acute myelogenous leukemia in adolescents and young adults. Pediatr Blood Cancer 65:e27089
Gilleland Marchak, Jordan; Seidel, Kristy D; Mertens, Ann C et al. (2018) Perceptions of risk of infertility among male survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer 124:2447-2455
Inaba, Hiroto; Cao, Xueyuan; Han, Alice Q et al. (2018) Bone mineral density in children with acute lymphoblastic leukemia. Cancer 124:1025-1035
Wilson, Carmen L; Howell, Carrie R; Partin, Robyn E et al. (2018) Influence of fitness on health status among survivors of acute lymphoblastic leukemia. Pediatr Blood Cancer 65:e27286
Mueller, Emily L; Park, Elyse R; Kirchhoff, Anne C et al. (2018) Insurance, chronic health conditions, and utilization of primary and specialty outpatient services: a Childhood Cancer Survivor Study report. J Cancer Surviv 12:639-646

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