Abstract

The Genome Stability and Research Program is one of two basic research programs in the Vermont Cancer Center. The program includes a diverse group of laboratory scientists with common interests in nucleic acids. DNA damage and repair, genes and gene expression, and cancer. The overall scientific focus of the program is on understanding the initiation and progression of neoplasia by analyzing and elucidating the mechanistic basis of DNA replication, DNA recombination, repair and gene expression, and the ways that these various cellular mechanisms related to DNA damaging agents (including cancer therapeutic agents) as well as the endogenous stability of the genome. Important expansion of the program has occurred in the areas of structural and computational biology. An ongoing effort is to define biomarkers with the ultimate goal of determining preventive strategies and providing the means for early diagnosis of cancer r pre-neoplastic conditions. Researchers in the program continue to explore the molecular and biochemical analysis of these events under the leadership of Susan. S. Wallace, Ph.D., Professor and Chair of the Department of the Microbiology and Molecular Genetics, and Director of the Markey Center for Molecular Genetics.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA022435-19
Application #
6563762
Study Section
Subcommittee G - Education (NCI)
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
19
Fiscal Year
2002
Total Cost
$78,870
Indirect Cost

  Institution

Name
University of Vermont & St Agric College
Department
Type
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405

  Publications

Kelemen, Linda E; Abbott, Sarah; Qin, Bo et al. (2017) Cigarette smoking and the association with serous ovarian cancer in African American women: African American Cancer Epidemiology Study (AACES). Cancer Causes Control 28:699-708
Long, Patrick M; Tighe, Scott W; Driscoll, Heather E et al. (2015) Acetate supplementation as a means of inducing glioblastoma stem-like cell growth arrest. J Cell Physiol 230:1929-43
Tsen, Andrew R; Long, Patrick M; Driscoll, Heather E et al. (2014) Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. Int J Cancer 134:1300-10
Wagner, Darcy E; Bonenfant, Nicholas R; Parsons, Charles S et al. (2014) Comparative decellularization and recellularization of normal versus emphysematous human lungs. Biomaterials 35:3281-97
Long, Patrick M; Tighe, Scott W; Driscoll, Heather E et al. (2013) Acetate supplementation induces growth arrest of NG2/PDGFR?-positive oligodendroglioma-derived tumor-initiating cells. PLoS One 8:e80714
Sokocevic, Dino; Bonenfant, Nicholas R; Wagner, Darcy E et al. (2013) The effect of age and emphysematous and fibrotic injury on the re-cellularization of de-cellularized lungs. Biomaterials 34:3256-69
Long, Patrick M; Moffett, John R; Namboodiri, Aryan M A et al. (2013) N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) promote growth and inhibit differentiation of glioma stem-like cells. J Biol Chem 288:26188-200
Bonenfant, Nicholas R; Sokocevic, Dino; Wagner, Darcy E et al. (2013) The effects of storage and sterilization on de-cellularized and re-cellularized whole lung. Biomaterials 34:3231-45
Murray, Janet M; Messier, Terri; Rivers, Jami et al. (2012) VDJ recombinase-mediated TCR ? locus gene usage and coding joint processing in peripheral T cells during perinatal and pediatric development. J Immunol 189:2356-64
Wallis, John M; Borg, Zachary D; Daly, Amanda B et al. (2012) Comparative assessment of detergent-based protocols for mouse lung de-cellularization and re-cellularization. Tissue Eng Part C Methods 18:420-32

Showing the most recent 10 out of 219 publications