Abstract

Many Cancer Center investigators focus on the effects and/or mechanisms of action of organic chemicals as they pertain to cancer biology. Such studies present a continuing need for custom synthesis of chemicals that are not commercially available. In particular, the cost of commercial custom synthesis for isotopically labeled compounds can restrict or eliminate the use of these valuable tools in some laboratories. Instrumentation for an expertise in the spectroscopic characterization of chemicals of unknown structure are also important in some Cancer Center investigations. Most research groups in the Cancer Center lack the expertise and equipment to effectively carry out multi-step syntheses and characterizations of organic compounds. A cost-effective solution is the establishment of a Synthetic Chemistry Shared Service to meet the needs of Cancer Center investigators. Specific objectives include: . Provide consultation to Cancer Center investigators on problems in chemical synthesis and modification. . Provide custom chemical syntheses of unlabeled compounds. . Provide custom syntheses of stable isotope or radio-isotope labeled compounds. . Provide assistance in the spectroscopic characterization of unknown compounds.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023074-25
Application #
6659177
Study Section
Project Start
2002-09-06
Project End
2003-06-30
Budget Start
Budget End
Support Year
25
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Arizona
Department
Type
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85722

  Publications

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Glassman, Caleb R; Parrish, Heather L; Lee, Mark S et al. (2018) Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex. Cell Rep 22:1263-1275
Nair, Uma S; Brady, Benjamin R; O'Connor, Patrick A et al. (2018) Factors Predicting Client Re-Enrollment in Tobacco Cessation Services in a State Quitline. Prev Chronic Dis 15:E126
Akam, E A; Utterback, R D; Marcero, J R et al. (2018) Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production. J Inorg Biochem 180:186-193
Hadinger, Kyle P; Marshalek, Joseph P; Sheeran, Paul S et al. (2018) Optimization of Phase-Change Contrast Agents for Targeting MDA-MB-231 Breast Cancer Cells. Ultrasound Med Biol 44:2728-2738
Han, Jiali; Li, Jianrong; Achour, Ikbel et al. (2018) Convergent downstream candidate mechanisms of independent intergenic polymorphisms between co-classified diseases implicate epistasis among noncoding elements. Pac Symp Biocomput 23:524-535
Galbraith, David W; Sliwinska, Elwira; Samadder, Partha (2018) Nuclear Cytometry: Analysis of the Patterns of DNA Synthesis and Transcription Using Flow Cytometry, Confocal Microscopy, and RNA Sequencing. Methods Mol Biol 1678:371-392
Nguyen, Mike M; Martinez, Jessica A; Hsu, Chiu-Hsieh et al. (2018) Bioactivity and prostate tissue distribution of metformin in a preprostatectomy prostate cancer cohort. Eur J Cancer Prev 27:557-562
Zeltzer, Sebastian; Zeltzer, Carol A; Igarashi, Suzu et al. (2018) Virus Control of Trafficking from Sorting Endosomes. MBio 9:

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