Abstract

9.1.1 ANALYTICAL CORE SHARED SERVICE The overall mission of the Analytical Core Shared Service (ACSS) is to provide Cancer Center investigators with centralized resources and expertise in performing analytical chemistry assays and pharmacokinetic and pharmacodynamic data analysis and interpretation. Specifically, the Analytical Core Shared Service has the following aims: ?To provide support in developing and implementing chromatography-based bioanalytical assays for quantification of cancer therapeutic and preventive agents, nutrients, carcinogens, and endogenous biochemicals in biological specimens; ?To provide support in quantitative analysis of cancer therapeutic and preventive agents, nutrients, carcinogens, and endogenous biochemicals in clinical and preclinical specimens; ?To provide support in developing proper sample handling and storage conditions for specimens collected for bioanalytical assays; ?To provide support in designing pharmacokinetic sample collection schedules and pharmacokinetic and pharmacodynamic data analysis and interpretation. These services allow for the assessment of drug/nutrient/carcinogen exposure and disposition. Services provided by ACSS also support measurement of endogenous chemicals as surrogate cancer-risk biomarkers and pharmacodynamic endpoints. These lines of research have been essential to many projects currently being carried out at the Arizona Cancer Center, especially in programs with an emphasis in drug development and cancer prevention research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023074-35
Application #
8540928
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
35
Fiscal Year
2013
Total Cost
$123,344
Indirect Cost
$42,288

  Institution

Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721

  Publications

McLamarrah, Tiffany A; Buster, Daniel W; Galletta, Brian J et al. (2018) An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly. J Cell Biol 217:1217-1231
Mannakee, Brian K; Balaji, Uthra; Witkiewicz, Agnieszka K et al. (2018) Sensitive and specific post-call filtering of genetic variants in xenograft and primary tumors. Bioinformatics 34:1713-1718
Glassman, Caleb R; Parrish, Heather L; Lee, Mark S et al. (2018) Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex. Cell Rep 22:1263-1275
Nair, Uma S; Brady, Benjamin R; O'Connor, Patrick A et al. (2018) Factors Predicting Client Re-Enrollment in Tobacco Cessation Services in a State Quitline. Prev Chronic Dis 15:E126
Akam, E A; Utterback, R D; Marcero, J R et al. (2018) Disulfide-masked iron prochelators: Effects on cell death, proliferation, and hemoglobin production. J Inorg Biochem 180:186-193
Hadinger, Kyle P; Marshalek, Joseph P; Sheeran, Paul S et al. (2018) Optimization of Phase-Change Contrast Agents for Targeting MDA-MB-231 Breast Cancer Cells. Ultrasound Med Biol 44:2728-2738
Han, Jiali; Li, Jianrong; Achour, Ikbel et al. (2018) Convergent downstream candidate mechanisms of independent intergenic polymorphisms between co-classified diseases implicate epistasis among noncoding elements. Pac Symp Biocomput 23:524-535
Galbraith, David W; Sliwinska, Elwira; Samadder, Partha (2018) Nuclear Cytometry: Analysis of the Patterns of DNA Synthesis and Transcription Using Flow Cytometry, Confocal Microscopy, and RNA Sequencing. Methods Mol Biol 1678:371-392
Nguyen, Mike M; Martinez, Jessica A; Hsu, Chiu-Hsieh et al. (2018) Bioactivity and prostate tissue distribution of metformin in a preprostatectomy prostate cancer cohort. Eur J Cancer Prev 27:557-562
Zeltzer, Sebastian; Zeltzer, Carol A; Igarashi, Suzu et al. (2018) Virus Control of Trafficking from Sorting Endosomes. MBio 9:

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