9.1.7 IMAGING CORE SHARED SERVICE The Cancer Center and affiliated programs house equipment and expertise in the development and application of a variety of in vivo imaging modilities including PET/SPECT, MR and optical approaches to in vivo imaging. The mission of the Imaging Core service is to provide Cancer Center members easy access to these state-of-the art in vivo imaging capabilities. Within this context, the Imaging Core provides three specific services to the Cancer Center members. An Institutional Imaging Advisory Committee provides a mechanism through which investigators may initiate projects, have them critically reviewed and facilitate access to appropriate image acquisition modalities. Optical imaging capabilities in confocal imaging, bioluminescence analysis of gene expression, and confocal endoscopy and spectroscopy are provided. The Core also provides access to technical expertise for operating and analyzing data acquired for pre-clinical MRI, PET/SPECT, and OCT, as well as. Clinical MRI approaches. A second area of focus, the Core is responsible for developing standardized platforms for image analysis housed in a centralized facility where experts in image processing and development of custom analysis algorithms are consolidated. The image processing facility, housed in the MRB, provides access to high end graphics computing capabilities, and experts who can provide both basic training and advice in image analysis approaches, as well as expertise to develop and customize specific image processing techniques. Thirdly, the Imaging Response Assessment Team (IRAT) has been incorporated into the ICSS for this renewal. The goal of this program is to increase the use of functional and molecular imaging endpoints as biomarkers in clinical drug trials. As such, all protocols initiated by AZCC investigators are vetted by the IRAT committee, who provide documented suggestions for inclusion of imaging endpoints. Consequently, the IRAT at AZCC will strictly conform to the ideals and concepts of the IRAT program and is committed to participating in the national consortium of IRATs focused on the use of quantitative imaging in clinical trials.

Public Health Relevance

The ICSS provides four specific services: (1) consultation on the development and application of imaging to projects within the AZCC;(2) access to, maintenance of, and expertise to operate specific image acquisition instruments;(3) access to sophisticated image analysis facilities and to expertise in image analysis and quantification, software development and operation, and (4) access to the IRAT.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023074-35
Application #
8540945
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
35
Fiscal Year
2013
Total Cost
$163,786
Indirect Cost
$56,035
Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Bea, Jennifer W; Jurutka, Peter W; Hibler, Elizabeth A et al. (2015) Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components. Metabolism 64:447-59
Leung, Sarah J; Rice, Photini S; Barton, Jennifer K (2015) In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis. Lasers Surg Med 47:40-9
Dickinson, Sally E; Rusche, Jadrian J; Bec, Sergiu L et al. (2015) The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. Mol Carcinog 54:1513-20
Quintero-Ramos, A; GutiƩrrez-Rubio, S A; Del Toro-Arreola, A et al. (2014) Association between polymorphisms in the thymidylate synthase gene and risk of breast cancer in a Mexican population. Genet Mol Res 13:8749-56
Landowski, Terry H; Gard, Jaime; Pond, Erika et al. (2014) Targeting integrin ?6 stimulates curative-type bone metastasis lesions in a xenograft model. Mol Cancer Ther 13:1558-66
Jiang, Yanlong; Kong, Qingke; Roland, Kenneth L et al. (2014) Membrane vesicles of Clostridium perfringens type A strains induce innate and adaptive immunity. Int J Med Microbiol 304:431-43
Gustafson, Heather L; Yao, Song; Goldman, Bryan H et al. (2014) Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma. Am J Hematol 89:639-45
Kang, Hyun-Jin; Kendrick, Samantha; Hecht, Sidney M et al. (2014) The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules. J Am Chem Soc 136:4172-85
Chow, H-H Sherry; Garland, Linda L; Heckman-Stoddard, Brandy M et al. (2014) A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones. J Transl Med 12:223
Lancaster, Jordan J; Juneman, Elizabeth; Arnce, Sarah A et al. (2014) An electrically coupled tissue-engineered cardiomyocyte scaffold improves cardiac function in rats with chronic heart failure. J Heart Lung Transplant 33:438-45

Showing the most recent 10 out of 852 publications