9.2 PROTOCOL SPECIFIC RESEARCH SUPPORT The goal of Protocol-Specific Research is to provide research nursing and data management support for conducting and completing innovative, early feasibility or proof-of-principle clinical trials originating from Arizona Cancer Center Programs. Priorities to obtain funding through this core will be given to translational clinical research studies. These may emanate from basic research at the Arizona Cancer Center, or they may involve laboratory correlates with concepts developed by clinicians. In either case, the top priority will be given to Investigator Initiated Trials (IITs). The University of Arizona continues to support the growth of the Investigator Initiated and early Phase I research studies, as demonstrated by an additional allocation of $500,000 in the current year for our clinical research efforts overall, and very specifically the innovative and early phase clinical studies. Minimum criteria for access to AZCC Protocol-Specific Research funds include the following: ? Research hypothesis was generated by an AZCC clinical investigator; ? Clinical trial represents a new initiative; ? Clinical trial has received approval with high priority from the AZCC Scientific Review Committee and the University of Arizona Human Subject's Committee; ? Principal investigator is a member of the AZCC; ? Final approval and disposition of these funds will be made by the AZCC Resource Committee. The Arizona Cancer Center Resource Allocation Committee meets bi-monthly and is composed of clinical investigators in leadership positions in AZCC Programs and Administration.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023074-35
Application #
8540969
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
35
Fiscal Year
2013
Total Cost
$80,135
Indirect Cost
$27,599
Name
University of Arizona
Department
Type
DUNS #
806345617
City
Tucson
State
AZ
Country
United States
Zip Code
85721
Bea, Jennifer W; Jurutka, Peter W; Hibler, Elizabeth A et al. (2015) Concentrations of the vitamin D metabolite 1,25(OH)2D and odds of metabolic syndrome and its components. Metabolism 64:447-59
Leung, Sarah J; Rice, Photini S; Barton, Jennifer K (2015) In vivo molecular mapping of the tumor microenvironment in an azoxymethane-treated mouse model of colon carcinogenesis. Lasers Surg Med 47:40-9
Dickinson, Sally E; Rusche, Jadrian J; Bec, Sergiu L et al. (2015) The effect of sulforaphane on histone deacetylase activity in keratinocytes: Differences between in vitro and in vivo analyses. Mol Carcinog 54:1513-20
Quintero-Ramos, A; GutiƩrrez-Rubio, S A; Del Toro-Arreola, A et al. (2014) Association between polymorphisms in the thymidylate synthase gene and risk of breast cancer in a Mexican population. Genet Mol Res 13:8749-56
Landowski, Terry H; Gard, Jaime; Pond, Erika et al. (2014) Targeting integrin ?6 stimulates curative-type bone metastasis lesions in a xenograft model. Mol Cancer Ther 13:1558-66
Jiang, Yanlong; Kong, Qingke; Roland, Kenneth L et al. (2014) Membrane vesicles of Clostridium perfringens type A strains induce innate and adaptive immunity. Int J Med Microbiol 304:431-43
Gustafson, Heather L; Yao, Song; Goldman, Bryan H et al. (2014) Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma. Am J Hematol 89:639-45
Kang, Hyun-Jin; Kendrick, Samantha; Hecht, Sidney M et al. (2014) The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules. J Am Chem Soc 136:4172-85
Chow, H-H Sherry; Garland, Linda L; Heckman-Stoddard, Brandy M et al. (2014) A pilot clinical study of resveratrol in postmenopausal women with high body mass index: effects on systemic sex steroid hormones. J Transl Med 12:223
Lancaster, Jordan J; Juneman, Elizabeth; Arnce, Sarah A et al. (2014) An electrically coupled tissue-engineered cardiomyocyte scaffold improves cardiac function in rats with chronic heart failure. J Heart Lung Transplant 33:438-45

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