The purview of basic cancer research is to address the fundamental mechanisms of biological processes that underlie the initiation and the progression of cancer. Over the past 2 decades, studies of cancer biology have led to the establishment of a general framework for tumor development. In this framework, a series of 8 biological events required for the formation of cancer have been identified: (a) increased cell proliferation, (b) decreased cell death, (c) defects in terminal differentiation, (d) escape from life-span restriction, (e) genome instability, (f) immune evasion, (g) angiogenesis, and (h) invasion and metastasis. Members of the Cancer Biology and Signaling (CBS) Program conduct basic research on the biological processes that underlie the initiation and progression of cancer. The scientific goals of the CBS Program are to fill some of those gaps in knowledge, focusing on fundamental mechanisms in 2 general areas of biology: signal transduction and cell growth. The CBS program has 34 members from 8 academic departments with $14.3 Million of peer-reviewed research grant funding (annual direct costs), including $3.4 Million from NCI. Members of the CBS Program published 751 programmatically aligned articles (2007-2012);10% were the result of intra-programmatic collaborations, 15% were inter-programmatic. Members participate in a monthly luncheon seminar series to exchange research results. The Cancer Center adds value to the research projects in CBS by providing shared facilities, consultation on state of the art technologies, human tissue samples, seed grants for translational research, and recruitment of outstanding investigators to Cancer Center Programs.

Public Health Relevance

The mission of the Moores Cancer Center is to translate research discoveries into meaningful advances to prevent, ameliorate and eliminate the burden of cancer. Members of the Cancer Biology and Signaling Program conduct basic research on the biological processes that underlie the initiation and progression of Cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA023100-28
Application #
8695638
Study Section
Subcommittee G - Education (NCI)
Project Start
1996-07-01
Project End
2019-04-30
Budget Start
2014-07-21
Budget End
2015-04-30
Support Year
28
Fiscal Year
2014
Total Cost
$26,049
Indirect Cost
$9,076
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Connor, Michael; Karunamuni, Roshan; McDonald, Carrie et al. (2017) Regional susceptibility to dose-dependent white matter damage after brain radiotherapy. Radiother Oncol 123:209-217
Ly, Peter; Teitz, Levi S; Kim, Dong H et al. (2017) Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining. Nat Cell Biol 19:68-75
Sundaramoorthy, Sriramkumar; Garcia Badaracco, Adrian; Hirsch, Sophia M et al. (2017) Low Efficiency Upconversion Nanoparticles for High-Resolution Coalignment of Near-Infrared and Visible Light Paths on a Light Microscope. ACS Appl Mater Interfaces 9:7929-7940
D'Antonio, Matteo; Woodruff, Grace; Nathanson, Jason L et al. (2017) High-Throughput and Cost-Effective Characterization of Induced Pluripotent Stem Cells. Stem Cell Reports 8:1101-1111
Guo, Shicheng; Diep, Dinh; Plongthongkum, Nongluk et al. (2017) Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA. Nat Genet 49:635-642
Jiang, Qingfei; Crews, Leslie A; Holm, Frida et al. (2017) RNA editing-dependent epitranscriptome diversity in cancer stem cells. Nat Rev Cancer 17:381-392
Martínez, María Elena; Gomez, Scarlett L; Tao, Li et al. (2017) Contribution of clinical and socioeconomic factors to differences in breast cancer subtype and mortality between Hispanic and non-Hispanic white women. Breast Cancer Res Treat 166:185-193
Krishnan, A P; Karunamuni, R; Leyden, K M et al. (2017) Restriction Spectrum Imaging Improves Risk Stratification in Patients with Glioblastoma. AJNR Am J Neuroradiol 38:882-889
Connor, Michael J; Marshall, Deborah C; Moiseenko, Vitali et al. (2017) Adverse Events Involving Radiation Oncology Medical Devices: Comprehensive Analysis of US Food and Drug Administration Data, 1991 to 2015. Int J Radiat Oncol Biol Phys 97:18-26
Panopoulos, Athanasia D; D'Antonio, Matteo; Benaglio, Paola et al. (2017) iPSCORE: A Resource of 222 iPSC Lines Enabling Functional Characterization of Genetic Variation across a Variety of Cell Types. Stem Cell Reports 8:1086-1100

Showing the most recent 10 out of 805 publications