The primary objective ofthe Cancer Prevention (CP) program is to use population science research methods to improve the knowledge base for promoting overall reductions in cancer incidence, mortality and morbidity. The CP program has 21 members from 11 academic departments. This group of investigators accomplishes its goals through effective integration of expertise in Family &Preventive Medicine, Psychiatry, Communication, Computer Science and Engineering, Pediatrics, Psychology, Surgery, Endocrinology, Reproductive Medicine, and Public Health. The program is organized in 3 major scientific themes as follows. Theme 1 is Cancer-Related Policy Research;Theme 2 is Diet, Obesity, and Cancer Risk;Theme 3 is Physical Activity Assessment and Interventions. In 2012, the CP program had $10.2 million of peer reviewed research grant funding (direct costs), including $4.1 million from NCI. Members ofthe CP program published 554 programmatically aligned articles since 2007;24% were the result of intra-programmatic collaborations and 20% were inter-programmatic. Significant scientific accomplishment include: (i) publication of the first report showing that nonsmoking policies have substantially reduced lung cancer rates in California and that this decline resulted from a decrease in the proportion of heavy smokers, (ii) the Women's Healthy Eating and Living (WHEL) study showed that maintenance of a low-fat diet high in vegetables, fruit, and fiber did not reduce recurrence or death in breast cancer survivors, and (iii) authorship of a landmark paper on built environment measures for physical activity. The program was active in 2012 with 1471 new patients in enrolled in intervention trials and 609 participants in observational studies. Proportions of participants by ethnic and racial categories approximate the MCC catchment area for adults aged 50 years and older (i.e., adults at risk of common-incidence cancers). The Cancer Center adds value to the research projects in CP by providing shared resource facilities, consultation on state of the art technologies, pilot project grants, opportunities for collaboration with other MCC programs, and recruitment of investigators.

Public Health Relevance

The primary objective ofthe Cancer Prevention (CP) program is to use population science research methods to improve the knowledge base for promoting overall reductions in cancer incidence, mortality and morbidity. The program focus areas include health behavior policy, studies of diet and obesity, and research in physical activity.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA023100-28
Application #
8695642
Study Section
Subcommittee G - Education (NCI)
Project Start
1996-07-01
Project End
2019-04-30
Budget Start
2014-07-21
Budget End
2015-04-30
Support Year
28
Fiscal Year
2014
Total Cost
$26,399
Indirect Cost
$9,198
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Sen, Supriya; Langiewicz, Magda; Jumaa, Hassan et al. (2015) Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice. Hepatology 61:171-83
Hoffmann, Hanne M; Tamrazian, Anika; Xie, Huimin et al. (2014) Heterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in mice. Endocrinology 155:4043-53
Hartman, Lisa L R; Crawford, John R; Makale, Milan T et al. (2014) Pediatric phase II trials of poly-ICLC in the management of newly diagnosed and recurrent brain tumors. J Pediatr Hematol Oncol 36:451-7
Williams, Richard T; Barnhill, Lisa M; Kuo, Huan-Hsien et al. (2014) Chimeras of p14ARF and p16: functional hybrids with the ability to arrest growth. PLoS One 9:e88219
Huang, Carlos P; Fofana, Mariama; Chan, Jefferson et al. (2014) Copper transporter 2 regulates intracellular copper and sensitivity to cisplatin. Metallomics 6:654-61
Paolini, Paul; Pick, Daniel; Lapira, Jennifer et al. (2014) Developmental and extracellular matrix-remodeling processes in rosiglitazone-exposed neonatal rat cardiomyocytes. Pharmacogenomics 15:759-74
Goellner, Eva M; Smith, Catherine E; Campbell, Christopher S et al. (2014) PCNA and Msh2-Msh6 activate an Mlh1-Pms1 endonuclease pathway required for Exo1-independent mismatch repair. Mol Cell 55:291-304
Glidewell-Kenney, Christine A; Trang, Crystal; Shao, Paul P et al. (2014) Neurokinin B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons. Endocrinology 155:3909-19
Jiang, P; Mukthavaram, R; Chao, Y et al. (2014) In vitro and in vivo anticancer effects of mevalonate pathway modulation on human cancer cells. Br J Cancer 111:1562-71
Jacques, Bonnie E; Montgomery 4th, William H; Uribe, Phillip M et al. (2014) The role of Wnt/*-catenin signaling in proliferation and regeneration of the developing basilar papilla and lateral line. Dev Neurobiol 74:438-56

Showing the most recent 10 out of 359 publications