The mission of the Solid Tumor Therapeutics Program (STT) is to develop novel therapeutics and the diagnostic tools needed to individualize their use. The strategy for executing this mission involves a spectrum of basic, translational and clinical research efforts directed toward the identification of susceptible molecular targets, and validation of their importance to tumor behavior;the identification and preclinical testing of potential new drugs and diagnostics that can guide their use/ and, the clinical testing of new drugs, diagnostics and therapeutic strategies. The STT program is organized around 4 major research themes: inflammation and cancer, angiogenesis and metastasis, drug discovery, development targentin and teseing;and imaging development The STT Program has 82 members from 18 academic departments with $18.9 Million in peer review research grant funding (annual direct costs), including $7.6 Million from NCI. STT members published 1391 programmatically aligned articles (2007-2012);10% were the result of intraprogrammatic collaborations, 11% were interprogrammatic.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA023100-28
Application #
8695645
Study Section
Subcommittee G - Education (NCI)
Project Start
1996-07-01
Project End
2019-04-30
Budget Start
2014-07-21
Budget End
2015-04-30
Support Year
28
Fiscal Year
2014
Total Cost
$27,979
Indirect Cost
$9,749
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Akers, Johnny C; Ramakrishnan, Valya; Yang, Isaac et al. (2016) Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid. Cancer Biomark 17:125-32
Hoffmann, Hanne M; Trang, Crystal; Gong, Ping et al. (2016) Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. J Neurosci 36:3506-18
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Nuyen, Brian A; Fox, Rina S; Malcarne, Vanessa L et al. (2016) Excessive Daytime Sleepiness as an Indicator of Depression in Hispanic Americans. Hisp Health Care Int 14:116-23
Ghosh, Pradipta; Aznar, Nicolas; Swanson, Lee et al. (2016) Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin. Curr Protoc Chem Biol 8:265-298
Johns, Claire; Seav, Susan M; Dominick, Sally A et al. (2016) Informing hot flash treatment decisions for breast cancer survivors: a systematic review of randomized trials comparing active interventions. Breast Cancer Res Treat 156:415-26

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