The goal of the Reducing Cancer Disparities (RCD) Program is to develop and test the effectiveness of interventions to reduce cancer risk and modify behaviors among underserved populations in the MCC catchment area. This goal is accomplished through highly interactive teams of 18 faculty members from UCSD and SDSU that include expertise from the Departments of Family and Preventive Medicine, Surgery, and Psychiatry at UCSD, as well as the Graduate School of Public Health and Psychology Department at SDSU. RCD is organized into 3 thematic foci: Theme 1: Lifestyle factors in community-based studies;Theme 2: Tobacco cessation;Theme 3: Screening and early detection. In 2012, the Program had $9.1 million of peer reviewed research grant funding (annual direct costs), which includes $5.4 million from NCI. Members of RCD published 255 programmatically aligned articles since 2007;20% were the result of intraprogrammatic collaborations and 25% were inter-programmatic. Significant accomplishments in the last grant period include: (i) increased publication number;(ii) doubling of peer-reviewed funding;(iii) doubling of NCI funding;and (iv) increase in number of multi-investigational grants from 1 to 5, which includes the NCI funded U54 SDSU-UCSD Cancer Center Comprehensive Partnership grant. In 2012, RCD investigators enrolled 831 individuals in intervention trials and 20,574 in observational studies. Importantly, the representation of racial/ethnic minorities in intervention studies is very high, with Hispanic/Latinos making up the majority. The RCD Program is the major entity targeting cancer research directly relevant to underserved and racial/ethnic minority populations in the MCC catchment area. The Cancer Center adds value to the RCD Program by providing shared resource facilities, pilot project grants, and recruitment of outstanding investigators.

Public Health Relevance

The primary goal of the Reducing Cancer Disparities (RCD) Program is to develop and test the effectiveness of interventions to reduce cancer risk and modify behaviors among underserved populations in the MCC catchment area. RCD focuses on three specific areas: (i) lifestyle factors in community-based studies;(ii) tobacco cessation;and (iii) screening and early detection.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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University of California San Diego
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Singh, Siddharth; Loomba, Rohit (2018) Role of two-dimensional shear wave elastography in the assessment of chronic liver diseases. Hepatology 67:13-15
Hartman, Sheri J; Nelson, Sandahl H; Myers, Emily et al. (2018) Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study. Cancer 124:192-202
Hoffmann, Hanne M; Gong, Ping; Tamrazian, Anika et al. (2018) Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol 461:143-154
Liu, Xuxiang; Cao, Minghui; Palomares, Melanie et al. (2018) Metastatic breast cancer cells overexpress and secrete miR-218 to regulate type I collagen deposition by osteoblasts. Breast Cancer Res 20:127
Huang, Justin K; Carlin, Daniel E; Yu, Michael Ku et al. (2018) Systematic Evaluation of Molecular Networks for Discovery of Disease Genes. Cell Syst 6:484-495.e5
Kalyanaraman, Hema; Schwaerzer, Gerburg; Ramdani, Ghania et al. (2018) Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes. Diabetes 67:607-623
Hartman, Sheri J; Marinac, Catherine R; Cadmus-Bertram, Lisa et al. (2018) Sedentary Behaviors and Biomarkers Among Breast Cancer Survivors. J Phys Act Health 15:1-6
Wu, Yan; Tamayo, Pablo; Zhang, Kun (2018) Visualizing and Interpreting Single-Cell Gene Expression Datasets with Similarity Weighted Nonnegative Embedding. Cell Syst 7:656-666.e4
Dow, Michelle; Pyke, Rachel M; Tsui, Brian Y et al. (2018) Integrative genomic analysis of mouse and human hepatocellular carcinoma. Proc Natl Acad Sci U S A 115:E9879-E9888
Que, Xuchu; Hung, Ming-Yow; Yeang, Calvin et al. (2018) Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558:301-306

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