The goal of the Cancer Imaging and Radiobiology Research Program (CIR) is to stimulate and promote investigations to develop and evaluate new cancer diagnostic and treatment strategies that utilize biophysics and engineering to improve imaging technology and to understand biological and physiological factors that influence the effectiveness of radiotherapy and other forms of treatment. CIR provides a forum for discussion and advancement of (a) novel preclinical and clinical imaging methods and modalities;(b) tools and techniques for in vivo oxygen assessment;(c) nanotechnology-mediated therapy and imaging;and (d) translation of these approaches into diagnostic and therapeutic clinical trials. The CIR has 19 members from six departments with $7.9 million in peer-reviewed funding (total costs, with $4.6 million from NCI, 58%) that includes awards in the P-series (P01, P41) and U-series (U54) funding mechanisms. The publication record over the past five years exceeds 230 papers of which approximately 58% involve intra-program collaborations and 18% represent inter-program collaborations. These data represent evidence of a highly productive and interactive research program. CIR research activities during the current funding period have led to the first technical reports and initial clinical evaluations of several innovative instrumentation platforms, including MR-guided NIR (near infrared) spectral imaging;microwave mammography;and clinical EPR oximetry. These and other cutting-edge developments involving electrical impedance spectroscopy, magnetic resonance elastography, fluorescence-guided resection, magnetic resonance microwave absorption imaging, nanoparticle hyperthermia, and magnetic nanoparticle imaging, among others, target cancers of breast, brain, head and neck, and prostate. These are tumor sites for which active diagnostic and therapeutic clinical studies are underway at NCCC. Research within the CIR currently focuses on (1) imaging structural and functional parameters associated with malignancy for detection, characterization, and therapyguidance of the disease;(2) measurement and assessment of oxygen during cancer treatment;and (3) delivery and assessment of agents and doses for evaluating new cancer imaging modalities, therapeutics and exposure outcomes. The range of physical techniques under investigation by the CIR membership provides a novel framework, enabled through NCCC support, for combining both conceptually and practically new approaches for clinical decision-making in the identification and management of cancer patients.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Dartmouth College
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Hou, Huagang; Krishnamurthy Nemani, Venkata; Du, Gaixin et al. (2015) Monitoring oxygen levels in orthotopic human glioma xenograft following carbogen inhalation and chemotherapy by implantable resonator-based oximetry. Int J Cancer 136:1688-96
Gilbert-Diamond, Diane; Li, Zhigang; Adachi-Mejia, Anna M et al. (2014) Association of a television in the bedroom with increased adiposity gain in a nationally representative sample of children and adolescents. JAMA Pediatr 168:427-34
Sheen, Mee Rie; Lizotte, Patrick H; Toraya-Brown, Seiko et al. (2014) Stimulating antitumor immunity with nanoparticles. Wiley Interdiscip Rev Nanomed Nanobiotechnol 6:496-505
Koestler, Devin C; Li, Jing; Baron, John A et al. (2014) Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon. Mod Pathol 27:145-55
Soderquist, Ryan; Pletnev, Alexandre A; Danilov, Alexey V et al. (2014) The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA. Apoptosis 19:201-9
Tang, Hongwei; Wei, Peng; Duell, Eric J et al. (2014) Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. Carcinogenesis 35:1039-45
Toraya-Brown, Seiko; Sheen, Mee Rie; Zhang, Peisheng et al. (2014) Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors. Nanomedicine 10:1273-85
O'Connor, Megan A; Green, William R (2014) Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis: lessons from a murine retrovirus-induced AIDS model. J Virol 88:2349-53
Tichauer, Kenneth M; Deharvengt, Sophie J; Samkoe, Kimberley S et al. (2014) Tumor endothelial marker imaging in melanomas using dual-tracer fluorescence molecular imaging. Mol Imaging Biol 16:372-82
Busch, Alexander M; Galimberti, Fabrizio; Nehls, Kristen E et al. (2014) All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Cancer Biol Ther 15:463-72

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