The Immune Monitoring Shared Resource (IMSR) provides (1) state-of-the-art immunoassays to allow NCCC clinicians to monitor the immune responses of patients enrolled in clinical trials;(2) quality control and quality assurance, including validation of the reproducibility of the result;(3) expert guidance in the choice and interpretation of immunoassays most relevant to a particular study or clinical trial;and (4) a resource for all NCCC Investigators and the Dartmouth community to use dedicated instruments not normally available in individual laboratories?e.g., ELISPOT reader, autoMACS, Robosep, Luminex. In 2005, the IMSR began a process of Proficiency Testing through membership in the Cancer Vaccine Consortium, and that has continued. Initial participation was in the ELISPOT panel, and, in 2007, participation was extended for the first time to pentamer-staining. The total operating budget for FY 2007 was $365,161, with total chargebacks of $109,773 requiring $255,388 in non-chargeback subvention, derived from a combination of the NCCC CCSG and Institutional resources. There is strong institutional support for this Shared Resource that comes from Dartmouth Medical School, from the NIH-NCRR COBRE Immunology/Inflammation Program Project, the Immunotherapy Center, the Department of Microbiology and Immunology, and the Department of Neurology. NCCC provided $66,603 or 26% of this non-chargeback subvention. We are requesting a budget of $117,498 from the NCCC CCSG for the first year of the competitive renewal, representing a more proportionate level than current support, approximately 45% of the non-chargeback subvention needed to support. The IMSR currently provides 18 NCCC members and their laboratories with services valued at $52,708 in chargebacks for FY 2007. NCCC members represent 72% of the total laboratories using this facility at Dartmouth. They used 61% of the services rendered, and that usage constitutes 48% of the total chargeback fees.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023108-35
Application #
8463391
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
2014-11-30
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
35
Fiscal Year
2013
Total Cost
$143,137
Indirect Cost
$52,543
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Shee, Kevin; Jiang, Amanda; Varn, Frederick S et al. (2018) Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer. FASEB J :fj201801241R
Rodriguez-Garcia, Marta; Fortier, Jared M; Barr, Fiona D et al. (2018) Aging impacts CD103+ CD8+ T cell presence and induction by dendritic cells in the genital tract. Aging Cell 17:e12733
Shajani-Yi, Zahra; de Abreu, Francine B; Peterson, Jason D et al. (2018) Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing. Neoplasia 20:256-262
Szczepiorkowski, Zbigniew M; Burnett, Christine A; Dumont, Larry J et al. (2018) Apheresis buffy coat collection without photoactivation has no effect on apoptosis, cell proliferation, and total viability of mononuclear cells collected using photopheresis systems. Transfusion 58:943-950
Bossé, Yohan; Amos, Christopher I (2018) A Decade of GWAS Results in Lung Cancer. Cancer Epidemiol Biomarkers Prev 27:363-379
Pande, Mala; Joon, Aron; Brewster, Abenaa M et al. (2018) Genetic susceptibility markers for a breast-colorectal cancer phenotype: Exploratory results from genome-wide association studies. PLoS One 13:e0196245
Smith, T Jarrod; Sondermann, Holger; O'Toole, George A (2018) Co-opting the Lap System of Pseudomonas fluorescens To Reversibly Customize Bacterial Cell Surfaces. ACS Synth Biol 7:2612-2617
Gorlova, Olga Y; Li, Yafang; Gorlov, Ivan et al. (2018) Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations. PLoS One 13:e0189498
Schmit, Stephanie L; Edlund, Christopher K; Schumacher, Fredrick R et al. (2018) Novel Common Genetic Susceptibility Loci for Colorectal Cancer. J Natl Cancer Inst :
Cai, Yunliang; Wu, Shaoju; Zhao, Wei et al. (2018) Concussion classification via deep learning using whole-brain white matter fiber strains. PLoS One 13:e0197992

Showing the most recent 10 out of 1911 publications