The primary mission of the Norris Cotton Cancer Center (NCCC) Irradiation Shared Resource (ISR) is to provide ionizing radiation services in support of basic and translational cell and animal experiments for the NCCC research community. The availability of a variety of radiation sources continues to allow the ISR to offer a broad and versatile irradiation capability with a wide range of energies and dose rates. The ISR operates multiple experimental and clinical irradiators, including a Cs-gamma source (12,000 Curie, Cs-137), an orthovoltage x-ray source (Pantak multiple energy, 300 KV x-irradiator), four linear accelerators from 6-20 MeV photons and 5-18 MeV electrons and an lr-192 high dose rate after-loader. Linear accelerator capabilities include Cone Beam CT, stereotactic radiosurgery and cardiac/respiration gated therapy. The ISR previously developed a number of advanced imaging instruments and services that now have been split off to constitute a developmental core in advanced animal imaging. The ISR currently provides 25 NCCC Pis and their laboratories with irradiation services. NCCC users represented 81% of the total laboratories using this facility at Dartmouth (25/31 labs total) for FY 2007, and their usage constituted 95% of the total based on units of use. Although the ISR provides critical support for certain NCCC projects and is cost-effective compared with the cost to individual labs to maintain and operate such irradiation sources independently, the overall user base is relatively small and specialized. Thus, the ISR requires a disproportionate level of support from the CCSG and other sources relative to its chargeback revenues. Fees are kept as low as practical, based on user feedback as to what researchers are able and willing to pay on a fee-for-service basis for these irradiations (e.g., fees would have to raise five-fold in order to recover total costs) and also based on comparisons with other institutions. Total chargebacks for this core were $15,466 for FY 2007, representing 17% of the total revenues, and the total operating budget was $91,869, requiring -$76,403 in subvention, derived from the NCCC Core Grant ($64,356, 70%) and other institutional resources ($12,047, 13%). The ISR is requesting a budget of $70,600 from the NCCC Core Grant for the first year of this renewal?a level comparable to the current year's support?for its total estimated operating budget for FY 2009 of approximately $89,523. The ISR continues to provide a variety of irradiation services for cell culture and experimental animal experiments to meet the needs of NCCC investigators, who are its principal users. The cesium irradiator continues to be the most heavily used irradiation service of the ISR. Although less heavily used, the clinical radiation sources have proved invaluable for specific projects, the overall goal of the ISR is to continue to support NCCC cancer researchers with these services at as low a rate as possible so that they can continue to successfully meet their research objectives individually and collectively.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Dartmouth College
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Hou, Huagang; Krishnamurthy Nemani, Venkata; Du, Gaixin et al. (2015) Monitoring oxygen levels in orthotopic human glioma xenograft following carbogen inhalation and chemotherapy by implantable resonator-based oximetry. Int J Cancer 136:1688-96
Gilbert-Diamond, Diane; Li, Zhigang; Adachi-Mejia, Anna M et al. (2014) Association of a television in the bedroom with increased adiposity gain in a nationally representative sample of children and adolescents. JAMA Pediatr 168:427-34
Sheen, Mee Rie; Lizotte, Patrick H; Toraya-Brown, Seiko et al. (2014) Stimulating antitumor immunity with nanoparticles. Wiley Interdiscip Rev Nanomed Nanobiotechnol 6:496-505
Koestler, Devin C; Li, Jing; Baron, John A et al. (2014) Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon. Mod Pathol 27:145-55
Soderquist, Ryan; Pletnev, Alexandre A; Danilov, Alexey V et al. (2014) The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA. Apoptosis 19:201-9
Tang, Hongwei; Wei, Peng; Duell, Eric J et al. (2014) Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data. Carcinogenesis 35:1039-45
Toraya-Brown, Seiko; Sheen, Mee Rie; Zhang, Peisheng et al. (2014) Local hyperthermia treatment of tumors induces CD8(+) T cell-mediated resistance against distal and secondary tumors. Nanomedicine 10:1273-85
O'Connor, Megan A; Green, William R (2014) Use of IRF-3 and/or IRF-7 knockout mice to study viral pathogenesis: lessons from a murine retrovirus-induced AIDS model. J Virol 88:2349-53
Tichauer, Kenneth M; Deharvengt, Sophie J; Samkoe, Kimberley S et al. (2014) Tumor endothelial marker imaging in melanomas using dual-tracer fluorescence molecular imaging. Mol Imaging Biol 16:372-82
Busch, Alexander M; Galimberti, Fabrizio; Nehls, Kristen E et al. (2014) All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Cancer Biol Ther 15:463-72

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