The Pathology Shared Resource (PSR) provides four primary services for NCCC investigators: (1) it partners researchers with appropriate pathologists to provide specific expertise matched to the needs of the research project;(2) it coordinates the procurement, preservation, and distribution of human tissues and cells for funded and developmental NCCC basic and clinical research;(3) it performs histologic, immunohistologic, and molecular diagnostic procedures for NCCC researchers;and (4) it provides a GMP cell processing laboratory for the isolation/purification, manipulation, expansion and/or storage of cells derived from a patient's/subject's peripheral blood intended for autologous reinfusion. The PSR also works closely with the other NCCC Shared Resources to coordinate activities, share methodologies and other resources, and develop collaborative services where there is overlapping or complementary expertise. These functions are coordinated by the PSR Director and the PSR Supervisor. All procurement and histology requests by researchers are directed to the PSR Supervisor, who in concert with the other Department of Pathology members translates these requests into written operational protocols. These and the histology/immunohistology requests constitute the majority of requests made of the PSR at this time, and these operations are supervised by the Director with the assistance of the Research Histology Supervisor who oversees the technical aspects of histology and immunohistology services. Computer databases preserve information on clinical parameters and tissues for ready access by investigators who have institutionally-approved protocols. Requests for molecular diagnostic studies are reviewed by the Director, but the service itself is supervised by the Director of Molecular Services. Requests for leukocytes derived by apheresis for vaccine development are handled by the Cell Processing Laboratory and are coordinated by the director of that service.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023108-35
Application #
8463394
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
2014-11-30
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
35
Fiscal Year
2013
Total Cost
$85,692
Indirect Cost
$31,457
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Zhang, Sai; Zhou, Jingtian; Hu, Hailin et al. (2016) A deep learning framework for modeling structural features of RNA-binding protein targets. Nucleic Acids Res 44:e32
Macura, Sherrill L; Lathrop, Melissa J; Gui, Jiang et al. (2016) Blocking CXCL9 Decreases HIV-1 Replication and Enhances the Activity of Prophylactic Antiretrovirals in Human Cervical Tissues. J Acquir Immune Defic Syndr 71:474-82
Whipple, Chery A; Boni, Andrea; Fisher, Jan L et al. (2016) The mitogen-activated protein kinase pathway plays a critical role in regulating immunological properties of BRAF mutant cutaneous melanoma cells. Melanoma Res 26:223-35
Sargent, Jennifer L; Li, Zhenghui; Aliprantis, Antonios O et al. (2016) Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics. Arthritis Rheumatol 68:2003-15
Hill, Courtney A; Beach, Michael; Smith, Mark C et al. (2016) Incidence of and Factors Associated With Hypogeusia in Healthy Children. JAMA Otolaryngol Head Neck Surg 142:229-33
Kim, Jung-Sik; He, Xiaoyuan; Orr, Bernardo et al. (2016) Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2. PLoS Genet 12:e1005865
Yang, Wei; Hosford, Sarah R; Dillon, Lloye M et al. (2016) Strategically Timing Inhibition of Phosphatidylinositol 3-Kinase to Maximize Therapeutic Index in Estrogen Receptor Alpha-Positive, PIK3CA-Mutant Breast Cancer. Clin Cancer Res 22:2250-60
Beach, Michael L; Cohen, Daniel M; Gallagher, Susan M et al. (2016) Major Adverse Events and Relationship to Nil per Os Status in Pediatric Sedation/Anesthesia Outside the Operating Room: A Report of the Pediatric Sedation Research Consortium. Anesthesiology 124:80-8
Allaway, Robert J; Fischer, Dawn A; de Abreu, Francine B et al. (2016) Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched metastatic sites. Oncotarget 7:17087-102
Liu, Yu-Chen; Li, Jian-Rong; Sun, Chuan-Hu et al. (2016) CircNet: a database of circular RNAs derived from transcriptome sequencing data. Nucleic Acids Res 44:D209-15

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