The mission of the Proteomics Shared Resource (PRSR) at the Norris Cotton Cancer Center (NCCC) is to provide NCCC investigators with local access to state-of-the-art proteomic technologies, scientific consulting For experimental design, consultation regarding results interpretation, and ancillary bioanalytical support services at affordable rates. Newly established as an independent NCCC Shared Resource, the PRSR in Fall 2007 completed its transition from providing limited proteomic services as part of the former Molecular Biology and Proteomics Shared Resource to full-fledged independent operation as a stand-alone core facility. During this transition, the PRSR acquired newly renovated laboratory space in the NCCC Rubin Building research labs, modernized its mass spectrometry and liquid chromatography instrumentation and expanded its computational resources, appointed proteomics faculty recruit Dr. Scott A. Gerber as Director of the PRSR, and expanded its service portfolio to include protein post-translational modification analysis and complex protein mixture analysis. These efforts collectively represent a $2.8 million commitment from the NCCC and From Dartmouth Medical School to bring a modern proteomics platform within reach of Cancer Center investigators and the greater Dartmouth research community as a whole. During this one-year transition phase, the PRSR received $12,700 in chargebacks from 9 NCCC research laboratories, or 87% of the total ($14,600) chargebacks for the facility (from a collective 16 Dartmouth laboratories). We estimate that the total operating cost of the PRSR for FY 2008 (year 1 of the CCSG renewal) will be $326,760 and anticipate $40,000 in total chargebacks, requiring $48,349 from CCSG and $238,411 from other sources for NCCC investigators (75% of the shortfall). Owing to the rapid increase in demand for PRSR services over the past year, we anticipate strong growth in the rate of chargebacks for the PRSR such that the large subsidy by NCCC and the institution can be reduced. Currently, support funds for the PRSR in transition are provided by multiple institutional sources.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023108-35
Application #
8463395
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
2014-11-30
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
35
Fiscal Year
2013
Total Cost
$58,898
Indirect Cost
$21,620
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Shee, Kevin; Jiang, Amanda; Varn, Frederick S et al. (2018) Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER+ breast cancer. FASEB J :fj201801241R
Rodriguez-Garcia, Marta; Fortier, Jared M; Barr, Fiona D et al. (2018) Aging impacts CD103+ CD8+ T cell presence and induction by dendritic cells in the genital tract. Aging Cell 17:e12733
Shajani-Yi, Zahra; de Abreu, Francine B; Peterson, Jason D et al. (2018) Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing. Neoplasia 20:256-262
Szczepiorkowski, Zbigniew M; Burnett, Christine A; Dumont, Larry J et al. (2018) Apheresis buffy coat collection without photoactivation has no effect on apoptosis, cell proliferation, and total viability of mononuclear cells collected using photopheresis systems. Transfusion 58:943-950
Bossé, Yohan; Amos, Christopher I (2018) A Decade of GWAS Results in Lung Cancer. Cancer Epidemiol Biomarkers Prev 27:363-379
Pande, Mala; Joon, Aron; Brewster, Abenaa M et al. (2018) Genetic susceptibility markers for a breast-colorectal cancer phenotype: Exploratory results from genome-wide association studies. PLoS One 13:e0196245
Smith, T Jarrod; Sondermann, Holger; O'Toole, George A (2018) Co-opting the Lap System of Pseudomonas fluorescens To Reversibly Customize Bacterial Cell Surfaces. ACS Synth Biol 7:2612-2617
Gorlova, Olga Y; Li, Yafang; Gorlov, Ivan et al. (2018) Gene-level association analysis of systemic sclerosis: A comparison of African-Americans and White populations. PLoS One 13:e0189498
Schmit, Stephanie L; Edlund, Christopher K; Schumacher, Fredrick R et al. (2018) Novel Common Genetic Susceptibility Loci for Colorectal Cancer. J Natl Cancer Inst :
Cai, Yunliang; Wu, Shaoju; Zhao, Wei et al. (2018) Concussion classification via deep learning using whole-brain white matter fiber strains. PLoS One 13:e0197992

Showing the most recent 10 out of 1911 publications