Clinical Pharmacology (CP) The Clinical Pharmacology (CP) Shared Resource is now in its 19th year of operation and primarily functions to support Norris Cotton Cancer Center (NCCC) investigators in the design, performance, data analysis, and interpretation of pharmacology objectives in preclinical (in vivo and ex-vivo), clinical, chemoprevention, and epidemiological studies, at lowest cost and highest value as possible. The major CPSR services are in 4 domains: (1) Central processing for biological fluids and tissues (e.g., cells, tumor tissue, plasma, saliva, urine, DNA) obtained as part of approved clinical and epidemiological protocols; services that include, but are not limited to, sample logging, processing (including processing peripheral blood mononuclear cells), aliquoting, storage and sample distribution when necessary; (2a) Development of novel analyte assays (when such assays are only available as research methods) using either high performance liquid chromatography (HPLC) with ultra-violet (UV) and/or fluorescence detection, or increasingly liquid-chromatography mass spectrometry (LC-MS/MS) methodology; (2b) Performance of analyte-concentration measurements in biological fluids and tissues for preclinical and clinical oncology studies using these validated bioanalytical assays; (3a) Expert consultation regarding study design and pharmacokinetic and pharmacodynamic hypothesis-development and testing in preclinical and clinical cancer studies; (3b) Pharmacokinetic (PK) and pharmacodynamic (PD) data analysis and PK-PD modeling from pre-clinical and clinical studies; and (4) Research pharmacy services for cancer therapeutic clinical studies with both commercially available drugs and drugs under an investigational new drug application (IND). CP is directed by Dr. Lionel D. Lewis, who has established expertise in the clinical performance, the pharmacokinetics, and the pharmacodynamics of early phase clinical studies of investigational oncology drug/drug combinations. Other staff include a junior faculty pharmacologist with bioanalytical and molecular pharmacology expertise, a research assistant-lab manager with biorepository and bioanalytical expertise, and a research pharmacist with expertise in oncologic and investigational drug pharmacy. During the period 12/01/2012 to 11/30/2013, members of the Molecular Therapeutics (MT) program were the most common and frequent users of CP services, representing 60% of use. However, CP provided important services to other NCCC program members. Cancer Epidemiology (CE) members represented 8.5% of users, Cancer Mechanisms (CM) members represented 8.5% of users, and Immunology & Cancer Immunotherapy (ICI) program members represented 17% of users.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023108-38
Application #
9204740
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2016-12-01
Budget End
2017-11-30
Support Year
38
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Emond, Jennifer A; Tovar, Alison; Li, Zhigang et al. (2017) FTO genotype and weight status among preadolescents: Assessing the mediating effects of obesogenic appetitive traits. Appetite 117:321-329
Rapuano, Kristina M; Zieselman, Amanda L; Kelley, William M et al. (2017) Genetic risk for obesity predicts nucleus accumbens size and responsivity to real-world food cues. Proc Natl Acad Sci U S A 114:160-165
Carroll, A M; Cheng, R; Collie-Duguid, E S R et al. (2017) Fine-mapping of genes determining extrafusal fiber properties in murine soleus muscle. Physiol Genomics 49:141-150
Fang, Jun; Jia, Jinping; Makowski, Matthew et al. (2017) Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148. Nat Commun 8:15034
Pan, Yongchu; Liu, Hongliang; Wang, Yanru et al. (2017) Associations between genetic variants in mRNA splicing-related genes and risk of lung cancer: a pathway-based analysis from published GWASs. Sci Rep 7:44634
Rothwell, Simon; Cooper, Robert G; Lundberg, Ingrid E et al. (2017) Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum. Arthritis Rheumatol 69:1090-1099
Hampsch, Riley A; Shee, Kevin; Bates, Darcy et al. (2017) Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer. Oncotarget 8:21806-21817
Barr, Paul J; Forcino, Rachel C; Thompson, Rachel et al. (2017) Evaluating CollaboRATE in a clinical setting: analysis of mode effects on scores, response rates and costs of data collection. BMJ Open 7:e014681
Melin, Beatrice S; Barnholtz-Sloan, Jill S; Wrensch, Margaret R et al. (2017) Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors. Nat Genet 49:789-794
Adachi-Mejia, Anna M; Lee, Chanam; Lee, Chunkuen et al. (2017) Geographic variation in the relationship between body mass index and the built environment. Prev Med 100:33-40

Showing the most recent 10 out of 1659 publications