The analysis of macromolecular structures by X ray crystallography provides data critical for understanding the beneficial and adverse functions of biological macromolecules and assemblies associated with cancer, which is a research focus of the Purdue University Center for Cancer Research's Chemical and Structural Biology Scientific Program. The Macromolecular Crystallography Shared Resource was established in 1998 and promotes cancer-related crystallographic research by ensuring the continuous availability of advanced facilities for crystallization and x-ray diffraction as well as the technical guidance necessary for their optimal use. The Macromolecular Crystallography Shared Resource provides essential services to the Chemical and Structural Biology Scientific Program in the Purdue University Center for Cancer Research and provides local, continuously available support to the internationally acclaimed research by Center for Cancer research crystallographers.
The role of the shared resource is to assist individual investigators and scientific Programs within the Center that are seeking novel approaches to addressing a variety of cancer-related issues. In offering these key services, the shared resource provides the expertise necessary for achieving the next challenge;challenges that when solved will aid in reducing the pain and suffering of cancer.
|Krisenko, Mariya O; Cartagena, Alexander; Raman, Arvind et al. (2015) Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B. Biochemistry 54:60-8|
|Cho, Eun Jung; Sun, Bo; Doh, Kyung-Oh et al. (2015) Intraperitoneal delivery of platinum with in-situ crosslinkable hyaluronic acid gel for local therapy of ovarian cancer. Biomaterials 37:312-9|
|Bai, Yu; Davis, Dexter C; Dai, Mingji (2014) Synthesis of tetrahydropyran/tetrahydrofuran-containing macrolides by palladium-catalyzed alkoxycarbonylative macrolactonizations. Angew Chem Int Ed Engl 53:6519-22|
|Chao, Chi-Hong; Chang, Chao-Ching; Wu, Meng-Ju et al. (2014) MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. J Clin Invest 124:3093-106|
|Lee, Kyuwan; Cui, Yi; Lee, Luke P et al. (2014) Quantitative imaging of single mRNA splice variants in living cells. Nat Nanotechnol 9:474-80|
|Yang, Yang; Haskins, Christopher W; Zhang, Wandi et al. (2014) Divergent total syntheses of lyconadins A and C. Angew Chem Int Ed Engl 53:3922-5|
|Ghosh, Arun K; Osswald, Heather L (2014) BACE1 (?-secretase) inhibitors for the treatment of Alzheimer's disease. Chem Soc Rev 43:6765-813|
|Byun, Alexander J; Hung, Kenneth E; Fleet, James C et al. (2014) Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras. Cancer Lett 347:191-5|
|Emmert, Dana; Campos, Christopher R; Ward, David et al. (2014) Reversible dimers of the atypical antipsychotic quetiapine inhibit p-glycoprotein-mediated efflux in vitro with increased binding affinity and in situ at the blood-brain barrier. ACS Chem Neurosci 5:305-17|
|Hrycyna, Christine A; Summers, Robert L; Lehane, Adele M et al. (2014) Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum. ACS Chem Biol 9:722-30|
Showing the most recent 10 out of 109 publications