Abstract

The analysis of macromolecular structures by X ray crystallography provides data critical for understanding the beneficial and adverse functions of biological macromolecules and assemblies associated with cancer, which is a research focus of the Purdue University Center for Cancer Research's Chemical and Structural Biology Scientific Program. The Macromolecular Crystallography Shared Resource was established in 1998 and promotes cancer-related crystallographic research by ensuring the continuous availability of advanced facilities for crystallization and x-ray diffraction as well as the technical guidance necessary for their optimal use. The Macromolecular Crystallography Shared Resource provides essential services to the Chemical and Structural Biology Scientific Program in the Purdue University Center for Cancer Research and provides local, continuously available support to the internationally acclaimed research by Center for Cancer research crystallographers.

Public Health Relevance

The role of the shared resource is to assist individual investigators and scientific Programs within the Center that are seeking novel approaches to addressing a variety of cancer-related issues. In offering these key services, the shared resource provides the expertise necessary for achieving the next challenge;challenges that when solved will aid in reducing the pain and suffering of cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023168-33
Application #
8470577
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
33
Fiscal Year
2013
Total Cost
$67,748
Indirect Cost
$23,351

  Institution

Name
Purdue University
Department
Type
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Alpsoy, Aktan; Dykhuizen, Emily C (2018) Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. J Biol Chem 293:3892-3903
Larocque, Elizabeth A; Naganna, N; Opoku-Temeng, Clement et al. (2018) Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase. ChemMedChem 13:1172-1180
Kumari, Rashmi; Silic, Martin R; Jones-Hall, Yava L et al. (2018) Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors. Oncotarget 9:23494-23504
VerHeul, Ross; Sweet, Craig; Thompson, David H (2018) Rapid and simple purification of elastin-like polypeptides directly from whole cells and cell lysates by organic solvent extraction. Biomater Sci 6:863-876
Poh, Scott; Chelvam, Venkatesh; Ayala-López, Wilfredo et al. (2018) Selective liposome targeting of folate receptor positive immune cells in inflammatory diseases. Nanomedicine 14:1033-1043
Coleman, Rachel A; Trader, Darci J (2018) A Sensitive High-Throughput Screening Method for Identifying Small Molecule Stimulators of the Core Particle of the Proteasome. Curr Protoc Chem Biol 10:e52
AlAbdi, Lama; He, Ming; Yang, Qianyi et al. (2018) The transcription factor Vezf1 represses the expression of the antiangiogenic factor Cited2 in endothelial cells. J Biol Chem 293:11109-11118
Lee, Hyeong-Min; Clark, Ellen P; Kuijer, M Bram et al. (2018) Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome. Mol Autism 9:45
Liu, Yunhua; Xu, Hanchen; Van der Jeught, Kevin et al. (2018) Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer. J Clin Invest 128:2951-2965
Weaver, Cory J; Terzi, Aslihan; Roeder, Haley et al. (2018) nox2/cybb Deficiency Affects Zebrafish Retinotectal Connectivity. J Neurosci 38:5854-5871

Showing the most recent 10 out of 436 publications