The Purdue University Center for Cancer Research Mass Spectrometry Shared Resource is part of the Purdue University Campus-wide Mass Spectrometry Center (CWMSC) and is operated under the Purdue University chargeback system. The Shared Resource has provided essential services for members of the Cancer Center for over twenty-five years and this service reflects the strength and national leadership of Purdue University in analytical chemistry. The Mass Spectrometry Shared Resource provides analysis services for small organic compounds that are mainly generated in the Medicinal Chemistry and Drug Delivery and Molecular Sensing scientific programs. The Shared Resource offers a full range of mass spectrometry ionization techniques including Electrospray Ionization (ESI), Matrix-Assisted Laser Desorption Ionization (MALDI) and Atmospheric Pressure Chemical Ionization (APCI) for the analysis of nonvolatile components. Electron Impact (El) and Chemical Ionization (Cl) for volatile components, Inductively Coupled Argon Plasma Ionization (ICP) for multi-element analysis and High Resolution Mass Measurement capabilities.
The role of the shared resource is to assist individual investigators and scientific Programs within the Center that are seeking novel approaches to addressing a variety of cancer-related issues. In offering these key services, the shared resource provides the expertise necessary for achieving the next challenge;challenges that when solved will aid in reducing the pain and suffering of cancer.
|Onel, Buket; Carver, Megan; Agrawal, Prashansa et al. (2018) The 3'-end region of the human PDGFR-? core promoter nuclease hypersensitive element forms a mixture of two unique end-insertion G-quadruplexes. Biochim Biophys Acta Gen Subj 1862:846-854|
|Sorlien, Erin L; Witucki, Mary A; Ogas, Joseph (2018) Efficient Production and Identification of CRISPR/Cas9-generated Gene Knockouts in the Model System Danio rerio. J Vis Exp :|
|Mani, Saravana Kumar Kailasam; Andrisani, Ourania (2018) Interferon signaling during Hepatitis B Virus (HBV) infection and HBV-associated hepatocellular carcinoma. Cytokine :|
|Dong, Cheng; Dong, Guangping; Li, Li et al. (2018) An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2. Commun Biol 1:183|
|Morman, Rosemary E; Schweickert, Patrick G; Konieczny, Stephen F et al. (2018) BATF regulates the expression of Nfil3, Wnt10a and miR155hg for efficient induction of antibody class switch recombination in mice. Eur J Immunol 48:1492-1505|
|Zhang, Zhuangzhuang; Cheng, Lijun; Li, Jie et al. (2018) Inhibition of the Wnt/?-Catenin Pathway Overcomes Resistance to Enzalutamide in Castration-Resistant Prostate Cancer. Cancer Res 78:3147-3162|
|Rangasamy, Loganathan; Chelvam, Venkatesh; Kanduluru, Ananda Kumar et al. (2018) New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K+/H+ Exchange. Bioconjug Chem 29:1047-1059|
|Zhang, Hao; Zhang, Yanqiu; Zhu, Xiaoyun et al. (2018) DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1. Hepatology :|
|Lee, Hyeon Jeong; Li, Jie; Vickman, Renee E et al. (2018) Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/?-catenin Pathway. Mol Cancer Res 16:974-985|
|Bhandari, Pushpak; Novikova, Gloriia; Goergen, Craig J et al. (2018) Ultrasound beam steering of oxygen nanobubbles for enhanced bladder cancer therapy. Sci Rep 8:3112|
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