The Center for Cancer Research's Proteomics Shared Resource is a new Shared Resource that combines various proteomic services (global proteomic, protein identification, and single protein analysis) in a single facility to better serve the needs of the Center for Cancer Research members. The Proteomics Shared Resource is distinguished from the Mass Spectrometry Shared Resource, which focuses on the analysis of small organic compounds to primarily support chemistry-driven projects in the Medicinal Chemistry and Drug Delivery and Molecular Sensing scientific programs. The advanced instrumentation in the Proteomic Shared Resource supports: 1) the high throughput analysis of biological fluids and tissue extracts;2) the identification of proteins in cellular complexes;and 3) the analysis of protein modifications. The Shared Resource is directed by Dr. Fred Regnier, the J. H. Law Distinguished Professor of Chemistry who has over 30 years experience as a leader in the field of applied mass spectrometry technology. Dr. Regnier is ideally suited to direct this new Shared Resource and to guide and facilitate new avenues of investigation by Center for Cancer Research members who may not be familiar with the capabilities the instrumentation the new facility offers.

Public Health Relevance

The role of the shared resource is to assist individual investigators and scientific Programs within the Center that are seeking novel approaches to addressing a variety of cancer-related issues. In offering these key services, the shared resource provides the expertise necessary for achieving the next challenge;challenges that when solved will aid in reducing the pain and suffering of cancer.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA023168-34
Application #
8681167
Study Section
Subcommittee B - Comprehensiveness (NCI)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
34
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
DUNS #
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Orellana, Esteban A; Tenneti, Srinivasarao; Rangasamy, Loganathan et al. (2017) FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer. Sci Transl Med 9:
Wyatt-Johnson, Season K; Herr, Seth A; Brewster, Amy L (2017) Status Epilepticus Triggers Time-Dependent Alterations in Microglia Abundance and Morphological Phenotypes in the Hippocampus. Front Neurol 8:700
Han, Ning; Pang, Liang; Xu, Jun et al. (2017) Development of Surface-Variable Polymeric Nanoparticles for Drug Delivery to Tumors. Mol Pharm 14:1538-1547
Wu, M-J; Kim, M R; Chen, Y-S et al. (2017) Retinoic acid directs breast cancer cell state changes through regulation of TET2-PKC? pathway. Oncogene 36:3193-3206
Jang, Yumi; Rao, Xiayu; Jiang, Qing (2017) Gamma-tocotrienol profoundly alters sphingolipids in cancer cells by inhibition of dihydroceramide desaturase and possibly activation of sphingolipid hydrolysis during prolonged treatment. J Nutr Biochem 46:49-56
Li, Jie; Wang, Ruixin; Kong, Yifan et al. (2017) Targeting Plk1 to Enhance Efficacy of Olaparib in Castration-Resistant Prostate Cancer. Mol Cancer Ther 16:469-479
Wang, Siwen; Xing, Zheng; Pascuzzi, Pete E et al. (2017) Metabolic Adaptation to Nutrients Involves Coregulation of Gene Expression by the RNA Helicase Dbp2 and the Cyc8 Corepressor in Saccharomyces cerevisiae. G3 (Bethesda) 7:2235-2247
Yue, Feng; Bi, Pengpeng; Wang, Chao et al. (2017) Pten is necessary for the quiescence and maintenance of adult muscle stem cells. Nat Commun 8:14328
Li, Guo; Low, Philip S (2017) Synthesis and evaluation of a ligand targeting the ? and ? opioid receptors for drug delivery to lung cancer. Bioorg Med Chem Lett 27:2074-2078
Chen, I-Hsuan; Xue, Liang; Hsu, Chuan-Chih et al. (2017) Phosphoproteins in extracellular vesicles as candidate markers for breast cancer. Proc Natl Acad Sci U S A 114:3175-3180

Showing the most recent 10 out of 370 publications