The Center Director has the authority and responsibility to define the Center's annual and long-term priorities and activities. Senior Leadership, Program Leaders and Faculty are significant contributors in the planning and evaluation process, as are Internal Advisory Groups consisting of the Program Planning Group (PPG), the Shared Resources Team, and the Administrative Team. External Advisory Groups consisting of the Cancer Center's Scientific Advisory Board (CCSAB) and Advisor for the Cancer Center Administration provide advice and new perspectives on current activities and future directions. Faculty provide input to planning and evaluation activities through Annual Reviews, Annual Faculty Retreat, and monthly Program Meetings. In these meetings. Program Leaders summarize the outcome of PPG discussions and actively solicit faculty feedback. This enhances the communication of Center goals to the faculty in a timely manner, and actively incorporates faculty opinions as part of developing plans. The Shared Resources Team evaluates the services of the core facilities in monthly meetings that are open to all faculty, and makes recommendations about future service needs and directions, including potential new instrumentation. Based on these sources of input, the PPG formulates specific annual goals and long-term plans, and presents these goals to CCSAB each spring. In parallel. Cancer Center's Administrative Team identifies mechanisms via which Center members can support these goals, through incentives such as pilot grant funding, development of core facilities and new instrumentation, and recruitment of new collaborating faculty. Once the goals are set, PPG and its ad hoc Task Forces consisting of several faculty members, including Recruitment and Pilot Project Committees, are primary drivers for implementing the goals that bring to the Center new technologies, new areas of research, and opportunities for scientific collaborations. Approved goals are distributed to all faculty and discussed in subsequent Program and Center meetings, to encourage Center-wide participation via various incentive mechanisms described above, and to assure continuous and iterative feedback from faculty on Center activities. Funding in the total amount of $16,000 is requested for the costs associated with the External Advisory Group activities, which include annual CCSAB meeting and annual Center Administration review. $20,000 is requested for the Annual Faculty Retreat. Institutional funds will be utilized to cover Internal Advisory Group activities, including monthly PPG, Administrative Team and Shared Resources Team meetings, as well as monthly Program meetings and Seminar Series.

Public Health Relevance

A strong planning and evaluation structure will permit the Center to identify both short-term and long-term scientific goals, to monitor progress toward meeting goals, and to plan for the facilities and financial support needed to meet these goals, thereby maximizing the scientific environment, collaborations and productivity of the Cancer Center Investigators.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Sanford-Burnham Medical Research Institute
La Jolla
United States
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Barile, Elisa; Marconi, Guya D; De, Surya K et al. (2017) hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents. ACS Chem Biol 12:444-455
Attali, Ilan; Tobelaim, William Sam; Persaud, Avinash et al. (2017) Ubiquitylation-dependent oligomerization regulates activity of Nedd4 ligases. EMBO J 36:425-440
Linares, Juan F; Cordes, Thekla; Duran, Angeles et al. (2017) ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Cell Metab 26:817-829.e6
Todoric, Jelena; Antonucci, Laura; Di Caro, Giuseppe et al. (2017) Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell 32:824-839.e8
Scortegagna, Marzia; Berthon, Annabel; Settas, Nikolaos et al. (2017) The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion. JCI Insight 2:
Jellusova, Julia; Cato, Matthew H; Apgar, John R et al. (2017) Gsk3 is a metabolic checkpoint regulator in B cells. Nat Immunol 18:303-312
Avellaneda Matteo, Diego; Grunseth, Adam J; Gonzalez, Eric R et al. (2017) Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency. J Biol Chem 292:7971-7983
Lee, Bongyong; Sahoo, Anupama; Marchica, John et al. (2017) The long noncoding RNA SPRIGHTLY acts as an intranuclear organizing hub for pre-mRNA molecules. Sci Adv 3:e1602505
McKeithan, Wesley L; Savchenko, Alex; Yu, Michael S et al. (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 8:766
Toome, Kadri; Willmore, Anne-Mari A; Paiste, Päärn et al. (2017) Ratiometric in vivo auditioning of targeted silver nanoparticles. Nanoscale 9:10094-10100

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