CCSG developmental funds during this past project period have enabled new junior faculty to successfully establish their research laboratories at the Institute. These funds have also helped relocate several established investigators to the Institute. The 11 faculty who received developmental funds from the CCSG grant during this past project period include Drs. Oldham, Z. Huang, Price, Ronai, Courtneidge, Riedl, Wolf, Cang, Petroski, Cosford, and Lee. A total of $2.1 MM of direct CCSG support was provided to these recruits over the last five years. The remainder of the recruitment commitment for these investigators is covered by the Institute. In addition, the Institute fully supported the recruitment of the following 10 Cancer Center members: Drs. Bodmer, Chanda, Hansen, Komatsu, Levine, Puri, Rana, Rickert, Terskikh, and Xu. Altogether, over $,17MM in total costs (direct funds and corresponding overhead) of institutional funds have been expended or committed in future years towards these 21 new Cancer Center members. The new Center members have been awarded total direct grant funds of over $27MM during this period, demonstrating a remarkable return on investment for our Developmental Funds. CCSG developmental funds were also used for pilot project grants, promoting collaborations and developing projects that enabled new research directions of strategic importance to the Center, and the accumulation of sufficient preliminary results to support new grant initiatives and publications. Pilot project funds were provided to Drs. Terskikh, Marassi, Ronai, Feng, Oshima, Cang, Reed, Jiang, Yamamoto, Hansen, Wolf, Osterman, Smith, Stallcup, Pasquale, Ranscht, and Millan. Also, several 'mini-projects' were funded, allowing the award recipients to take advantage of our cutting-edge Shared Resources, again enabling new research directions, and submission of grant applications and publications. Lastly, CCSG funds were used to support the establishment of a new Shared Resource, Functional Genomics. This Shared Resource is now fully operational, and widely used by Cancer Center members. During the next project period, we expect to add 10-12 new investigators to the Cancer Center. We request support for two new Cancer Center faculty per year at $175,000 each ($350,000 total per year) for salary support, support for postdoctoral associates, and supplies. This is less than 20% of the expected total cost; the remainder of the recruitment commitment will be provided from institutional sources. Support is also requested for 2-3 pilot projects annually at $50,000-$75,000 each ($150,000 total per year) for collaborative pilot grants and for pilot grants under the Chemical Biology Initiative. Total Developmental Funds requested: $500,000.

Public Health Relevance

The CCSG Developmental Funds are a crucial resource to help the Cancer Center achieve its mission of facilitating the abilities of our members to perform cutting-edge, collaborative cancer research, and facilitating the recruitment of outstanding scientists to our Center.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Sanford-Burnham Medical Research Institute
La Jolla
United States
Zip Code
Lechtenberg, Bernhard C; Rajput, Akhil; Sanishvili, Ruslan et al. (2016) Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation. Nature 529:546-50
Zhong, Zhenyu; Umemura, Atsushi; Sanchez-Lopez, Elsa et al. (2016) NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell 164:896-910
Olson, Erika J; Lechtenberg, Bernhard C; Zhao, Chunxia et al. (2016) Modifications of a Nanomolar Cyclic Peptide Antagonist for the EphA4 Receptor To Achieve High Plasma Stability. ACS Med Chem Lett 7:841-6
Tinoco, Roberto; Carrette, Florent; Barraza, Monique L et al. (2016) PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion. Immunity 44:1190-203
Zhao, Wei; Mazar, Joseph; Lee, Bongyong et al. (2016) The Long Noncoding RNA SPRIGHTLY Regulates Cell Proliferation in Primary Human Melanocytes. J Invest Dermatol 136:819-28
Singec, Ilyas; Crain, Andrew M; Hou, Junjie et al. (2016) Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling. Stem Cell Reports 7:527-42
McQuary, Philip R; Liao, Chen-Yu; Chang, Jessica T et al. (2016) C. elegans S6K Mutants Require a Creatine-Kinase-like Effector for Lifespan Extension. Cell Rep 14:2059-67
Moscat, Jorge; Karin, Michael; Diaz-Meco, Maria T (2016) p62 in Cancer: Signaling Adaptor Beyond Autophagy. Cell 167:606-609
Miletic, Ana V; Jellusova, Julia; Cato, Matthew H et al. (2016) Essential Role for Survivin in the Proliferative Expansion of Progenitor and Mature B Cells. J Immunol 196:2195-204
Koh, Mei Yee; Gagea, Mihai; Sargis, Timothy et al. (2016) A new HIF-1α/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice. Hepatology 63:1576-91

Showing the most recent 10 out of 425 publications