The overall goal of the Signal Transduction Program (STP) is to elucidate the mechanisms that govern activation and repression of signaling cascades during normal development, neoplastic transformation and tumor progression. This goal is based on the premise that abnormalities in signal transduction are universal features of human cancer cells, and underiie virtually all aspects of the transformed phenotype. Members of the Signal Transduction Program currently pursue three major investigative areas: (1) kinases and phosphatases that are important in tumor development and known to undergo changes in human tumors;(2) ubiquitin ligases and ubiquitin-like proteins that play important roles in cellular pathways that are deregulated during tumor development and progression;and (3) an emerging theme of altered metabolic signaling in cancer. The Signal Transduction Program was established in 2001, and has been greatly strengthened since the last renewal by recruitment of new faculty members with expertise that complements the interests of the original faculty members. Of the 16 current members, 11 members have been recruited since 2003. Among them is Dr. Ze'ev Ronai, who was recruited as new Program Leader for the Signal Transduction Program in 2004. The Program is highly collaborative and interactive as evidenced by joint laboratory meetings, joint mentoring of graduate students and postdoctoral fellows, joint mentoring program for young faculty, monthly postdoctoral fellow presentations, monthly faculty meetings, monthly interest group (ubiquitin, ER stress) meetings, the annual postdoctoral retreat, and several Program Project grant initiatives underway. As a result of these activities, Program members lead or participate in 4 POl grants (2 from NCI), in multiple shared federal and state grants, and multiple co-authored publications. The high productivity of the Program during the past grant period is further documented by 21 ROI grants (7 from NCI) held by the Program members;by the current total annual grant funding of $14.5MM ($8.2MM direct);by 392 publications since last review, and by 65 Program publications in 2008, which represent 11% of intra- and 31% of interprogrammatic collaborations, respectively.

Public Health Relevance

Abnormalities in signal transduction underiie virtually all aspects of the transformed phenotype. Understanding these processes is expected to produce insights into the development and progression of cancer, to facilitate the development of tools to better probe the biology of cancer, and, ultimately, serve as guidance for therapeutics development.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Sanford-Burnham Medical Research Institute
La Jolla
United States
Zip Code
Fujita, Yu; Khateb, Ali; Li, Yan et al. (2018) Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis. Cell Rep 24:3296-3311.e6
Scully, Kathleen M; Lahmy, Reyhaneh; Signaevskaia, Lia et al. (2018) E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4A and Wild-Type p53. Cell Mol Gastroenterol Hepatol 6:181-198
Borlido, Joana; Sakuma, Stephen; Raices, Marcela et al. (2018) Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. Nat Immunol 19:594-605
Follis, Ariele Viacava; Llambi, Fabien; Kalkavan, Halime et al. (2018) Regulation of apoptosis by an intrinsically disordered region of Bcl-xL. Nat Chem Biol 14:458-465
Pathria, Gaurav; Scott, David A; Feng, Yongmei et al. (2018) Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival. EMBO J 37:
Sun, Younguk; Chen, Bo-Rui; Deshpande, Aniruddha (2018) Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia. Front Oncol 8:41
Ekanayake, Vindana; Nisan, Danielle; Ryzhov, Pavel et al. (2018) Lipoprotein Particle Formation by Proapoptotic tBid. Biophys J 115:533-542
Diez-Cuñado, Marta; Wei, Ke; Bushway, Paul J et al. (2018) miRNAs that Induce Human Cardiomyocyte Proliferation Converge on the Hippo Pathway. Cell Rep 23:2168-2174
Wang, Yang; Li, Yue; Yue, Minghui et al. (2018) N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci 21:195-206
Lundquist, Mark R; Goncalves, Marcus D; Loughran, Ryan M et al. (2018) Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Mol Cell 70:531-544.e9

Showing the most recent 10 out of 599 publications