The Biostatistics Core (BC) provides statistical expertise to support study design and data analysis for basic, translational, clinical, and population research at the COHCCC. Areas of expertise include clinical trials;epidemiology;genetics and functional genomics;pharmacokinetic modeling;assays, bioassays, and diagnostics;and animal toxicology testing;as well general statistical methods for data summary, inference, and prediction. The faculty statisticians of the core collaborate in pilot projects, grant proposals, clinical protocols, and publications. Staff statisticians provide additional support, focusing on statistical computing, including the retrieval of data from a variety of databases. The collaborative activities of BC statisticians cover the entire life cycle of a research project, from study design and proposal writing, through monitoring and interim analysis, to final data analyses, statistical graphics and manuscript writing. In addition to supporting collaborative research, the core provides short-term consulting and case-finding services for investigators. Statisticians work closely with the Clinical Protocol and Data Management Core (CPDMC) to ensure that clinical trials are equipped with appropriate case-report forms, databases, and electronic data capture tools. The BC also works closely with the Bioinformatics Core to provide both routine and specialized analysis of functional genomics data. Retrospective studies are often supported by retrieval of data from the COH Cancer Registry, the HSC Transplant database, or other research and clinical repositories. The core provides expertise and access to statistical software such as SAS, JMP, Splus, R, StatXact/LogXact, East, and Nquery, as well as specialized statistical computing tools for microarrays, RNA sequence, human and experimental genetic studies, pharmacokinetics, and clinical trials. Core statisticians provide the Cancer Center with statistical reviews of clinical research protocols, and service on the Cancer Protocol Review and Monitoring Committee (CPRMC), the Institutional Review Board (IRB), and the Data and Safety Monitoring Committee (DSMC). The staff of the BC includes a large part of the Division of Biostatistics, within the Department of Information Science, and the BC enables their participation in Cancer Center-related pilot projects and proposals, which may later develop into externally funded projects. Between 7/1/10 and 6/30/11, the BC was used by 116 principal investigators, 75 of whom are CC members. The BC staff coauthored 33 peer-reviewed cancer-related publications in 2010, and co-authored another 42 by the third quarter of 2011. '

Public Health Relevance

The overall goal of the Biostatistics core facility is to provide statistical expertise for study design and data analysis for basic, translational, clinical and population research. Highly trained facility statisticians collaborate with cancer center investigators for the entire life cycle of the research project, from design to final analyses. This goal enhances the Cancer Center's dedication to developing innovative new disease fighting strategies in the battle against cancer.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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City of Hope/Beckman Research Institute
United States
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Israyelyan, A; Goldstein, L; Tsai, W et al. (2015) Real-time assessment of relapse risk based on the WT1 marker in acute leukemia and myelodysplastic syndrome patients after hematopoietic cell transplantation. Bone Marrow Transplant 50:26-33
Jonnalagadda, Mahesh; Mardiros, Armen; Urak, Ryan et al. (2015) Chimeric antigen receptors with mutated IgG4 Fc spacer avoid fc receptor binding and improve T cell persistence and antitumor efficacy. Mol Ther 23:757-68
Salhotra, A; Tsai, N; Thomas, S H et al. (2015) Sclerodermatous chronic GVHD in patients receiving tyrosine kinase inhibitors after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 50:139-41
Ali, H; Palmer, J; Eroglu, Z et al. (2015) Mycophenolate mofetil-based salvage as acute GVHD prophylaxis after early discontinuation of tacrolimus and/or sirolimus. Bone Marrow Transplant 50:307-9
Behrendt, Carolyn E; Hurria, Arti; Tumyan, Lusine et al. (2014) Socioeconomic and clinical factors are key to uncovering disparity in accrual onto therapeutic trials for breast cancer. J Natl Compr Canc Netw 12:1579-85
Yang, Lixin; Perez, Aldwin Apollo; Fujie, Sayuri et al. (2014) Wnt modulates MCL1 to control cell survival in triple negative breast cancer. BMC Cancer 14:124
Gillis, Peter A; Hernandez-Alvarado, Nelmary; Gnanandarajah, Josephine S et al. (2014) Development of a novel, guinea pig-specific IFN-? ELISPOT assay and characterization of guinea pig cytomegalovirus GP83-specific cellular immune responses following immunization with a modified vaccinia virus Ankara (MVA)-vectored GP83 vaccine. Vaccine 32:3963-70
Chen, Shiuan; Zhou, Dujin; Hsin, Li-Yu et al. (2014) AroER tri-screen is a biologically relevant assay for endocrine disrupting chemicals modulating the activity of aromatase and/or the estrogen receptor. Toxicol Sci 139:198-209
Bhatia, Smita; Landier, Wendy; Hageman, Lindsey et al. (2014) 6MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children's Oncology Group study. Blood 124:2345-53
Sun, Virginia; Grant, Marcia; McMullen, Carmit K et al. (2014) From diagnosis through survivorship: health-care experiences of colorectal cancer survivors with ostomies. Support Care Cancer 22:1563-70

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