Community Outreach and Engagement ABSTRACT The City of Hope Comprehensive Cancer Center (COHCCC) is a freestanding cancer center whose main campus is located in Duarte, California. The COHCCC Catchment Area includes the entirety of Los Angeles and Orange Counties and portions of Ventura, Riverside, and San Bernardino Counties. The Catchment Area is bounded by the Pacific Ocean to the south and west; Antelope Valley to the north; Santa Clarita and Simi Valley to the west; the metropolitan areas of Riverside and San Bernardino to the east; and the communities of Palm Desert, Murrieta, and San Clemente to the south. The COHCCC Catchment Area covers 9,365 square miles and includes the heart of the greater Los Angeles metropolitan area and more inland communities. We serve a multi-racial, multi-ethnic community of over 17.1 million individuals, which represents approximately 40 percent of all Californians. Remarkably, the population of our Catchment Area is greater than the individual populations of 46 states and greater than the populations of 14 states combined. The COHCCC seeks to use its research and resources to improve the lives of the men, women, and children who live in our Catchment Area, particularly in the more inland regions. The residents we serve face challenges that impact cancer survival, including poverty, obesity, and lack of access. These challenges are uniformly faced whether an individual comes from urban or more rural environments. To achieve this goal, COHCCC has three themes: 1. Identify and pursue challenging questions in cancer research relevant to the people of our Catchment Area. 2. Develop and implement strategies for including underserved populations in our programmatic research. 3. Take advantage of research discoveries, collaborations, networks, and affiliates to extend our reach and to implement creative interventions to increase access and health equity within our Catchment Area, as well as nationally and internationally. To reduce the incidence of cancer in the unique populations we serve within our Catchment Area, we identified the following priorities: ? Biologically aggressive cancers that impact diverse populations in our COHCCC Catchment Area ? Viral-related cancers, including hepatocellular carcinoma and HIV-related malignancies ? Impact of pollution on cancer incidence, with a focus on breast and lung cancer ? Cancers of aging in Asian- and Latino-Americans

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA033572-35
Application #
9491639
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-04-20
Budget End
2018-11-30
Support Year
35
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Beckman Research Institute/City of Hope
Department
Type
DUNS #
027176833
City
Duarte
State
CA
Country
United States
Zip Code
91010
Sen, Subha; Wang, Fei; Zhang, Jing et al. (2018) SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate ROR?t activity in a PKC-?-dependent manner. Proc Natl Acad Sci U S A 115:E458-E467
Murad, John P; Kozlowska, Anna K; Lee, Hee Jun et al. (2018) Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells. Front Immunol 9:2268
Miao, Yifei; Ajami, Nassim E; Huang, Tse-Shun et al. (2018) Enhancer-associated long non-coding RNA LEENE regulates endothelial nitric oxide synthase and endothelial function. Nat Commun 9:292
Fujita-Yamaguchi, Yoko; Bagramyan, Karine; Yamaguchi, Yoshiki et al. (2018) Mass spectrometric revival of an l-rhamnose- and d-galactose-specific lectin from a lost strain of Streptomyces. J Biol Chem 293:368-378
Kanteti, Rajani; Mirzapoiazova, Tamara; Riehm, Jacob J et al. (2018) Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma. Cancer Biol Ther 19:316-327
Brown, Christine E; Aguilar, Brenda; Starr, Renate et al. (2018) Optimization of IL13R?2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma. Mol Ther 26:31-44
Leung, Amy; Trac, Candi; Kato, Hiroyuki et al. (2018) LTRs activated by Epstein-Barr virus-induced transformation of B cells alter the transcriptome. Genome Res 28:1791-1798
Tobin, Steven J; Wakefield, Devin L; Jones, Veronica et al. (2018) Single molecule localization microscopy coupled with touch preparation for the quantification of trastuzumab-bound HER2. Sci Rep 8:15154
Smith, Laura J; Wright, Jason; Clark, Gabriella et al. (2018) Stem cell-derived clade F AAVs mediate high-efficiency homologous recombination-based genome editing. Proc Natl Acad Sci U S A 115:E7379-E7388
Pal, Sumanta K; He, Miaoling; Chen, Lin et al. (2018) Synaptophysin expression on circulating tumor cells in patients with castration resistant prostate cancer undergoing treatment with abiraterone acetate or enzalutamide. Urol Oncol 36:162.e1-162.e6

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