The Mouse Models Resource (MMR) provides TJL Cancer Center investigators with access to approximately 800 of the 2,900 publicly available strains available from TJL's Genetic Resource Repository. The MMR also provides information about these strains, and the expertise of scientists in the Genetic Resource Program. The live Resource, together with Resource strains available from the Cryopreservation Resource comprises the Genetic Resource Repository and is the largest single collection of genetically defined mouse strains anywhere in the world. The Mouse Models Resource provides TJL Cancer Center members with small numbers of mice from the Repository free of charge. Cancer Center members can obtain breeding pairs and small numbers of mutants and controls from mutant strains, or individual mice from strain panels. Cancer Center members add value to the strains by further characterizing them;this scientific information is added to the strain information database from resulting publications or by electronic transmission directly into the Mouse Phenome Database for strain panels. The Resource contains mouse strains carrying spontaneous, induced, and genetically engineered mutations; mice with chromosome aberrations;and special inbred strains and strain panels, including wild-derived inbred, congenic, Recombinant Inbred (Rl), and consomic strains. For insurance against loss and economic management of very low demand strains, all strains are cryopreserved as embryos or gametes through the Reproductive Sciences program, and DNA from most strains is available through the Mouse DNA Resource in Genome Sciences. Genetic Resource Technical Information Scientists gather, curate, and maintain the operational and scientific information about these strains. Mouse Models Resource personnel provide genetic expertise and advice, and colony maintenance advice, including special husbandry needs and biological information, about the mice in the Resource. Resource personnel also provide a core of geneticists who have many years of experience and extensive knowledge and expertise in a variety of areas related to gene mapping, mouse genetics, and mouse husbandry and biology. The MMR occupies 7,345 ft2 of vivarium and procedure space in Building 32 and the Functional Genomics Building. Dr. Muriel Davisson, Senior Staff Scientist, Director of Genetic Resources, is the Project Leader responsible for administration and coordination of Mouse Models Resource programs with each other and with other Resources and Scientific Services at TJL.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA034196-28S2
Application #
8476496
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-08-01
Project End
2013-06-30
Budget Start
2012-08-03
Budget End
2013-06-30
Support Year
28
Fiscal Year
2012
Total Cost
$213,323
Indirect Cost
$91,424
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Wang, Qianghu; Hu, Baoli; Hu, Xin et al. (2017) Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell 32:42-56.e6
Herbert Pratt, C; Potter, Christopher S; Kuiper, Raoul V et al. (2017) Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ. Exp Mol Pathol 102:128-132
Burack, W Richard; Spence, Janice M; Spence, John P et al. (2017) Patient-derived xenografts of low-grade B-cell lymphomas demonstrate roles of the tumor microenvironment. Blood Adv 1:1263-1273
Hosur, Vishnu; Low, Benjamin E; Avery, Cindy et al. (2017) Development of Humanized Mice in the Age of Genome Editing. J Cell Biochem 118:3043-3048
Pratt, C Herbert; King Jr, Lloyd E; Messenger, Andrew G et al. (2017) Alopecia areata. Nat Rev Dis Primers 3:17011
Sutphin, George L; Backer, Grant; Sheehan, Susan et al. (2017) Caenorhabditis elegans orthologs of human genes differentially expressed with age are enriched for determinants of longevity. Aging Cell 16:672-682
Verma, Mohit K; Clemens, Julia; Burzenski, Lisa et al. (2017) A novel hemolytic complement-sufficient NSG mouse model supports studies of complement-mediated antitumor activity in vivo. J Immunol Methods 446:47-53
Kooreman, Nigel G; de Almeida, Patricia E; Stack, Jonathan P et al. (2017) Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics. Cell Rep 20:1978-1990
Hosur, Vishnu; Burzenski, Lisa M; Stearns, Timothy M et al. (2017) Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing. Exp Mol Pathol 102:337-346
Hwang, Grace; Sun, Fengyun; O'Brien, Marilyn et al. (2017) SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Development 144:1648-1660

Showing the most recent 10 out of 1039 publications