The JAXCC developed a new strategic plan in 2012 that lays out initiatives for growth in genomic technologies, computational analytics, and mouse model systems that serve as robust research platforms for interrogating the genomic complexity of human cancers. These strategies converge on the common goal of establishing new preventative and therapeutic treatments based on the individual cancer genome. The plan sets objectives for growth in research, resources and education, which guide budgetary decisions, faculty recruiting, facilities design, shared resource expansion, equipment purchases, and other activities. The JAXCC External Advisory Board (EAB) meets annually with the JAXCC senior leadership to review progress toward meeting the strategic objectives;advise on strategic partnerships, especially those that advance the JAXCC's translational outreach;review JAXCC policies and governance practices;review the shared resources;and evaluate the usage of developmental funds. Chaired by Edward Benz, MD (Dana Farber Cancer Institute), the EAB members are senior leaders in NCI-designated Cancer Centers and include Michael Friedman, MD (City of Hope Cancer Center) Mark Israel, MD (Norris Cotton Cancer Center); Jill Mesirov, PhD (The Broad Institute and Koch Institute for Integrative Cancer Research);Stuart Orkin, MD (Dana Farber Cancer Institute);Pier Paolo Pandolfi, MD, PhD (Beth Israel Deaconess Cancer Center);Frank Torti, MD, PhD (University of Connecticut Health Center);and Barbara Vance, PhD, CRA (NYU Cancer Institute). CCSG funds are requested for support of the annual EAB meeting. Funds are requested to support the annual EAB meeting. The JAXCC Scientific Executive Committee (SEC) comprises the senior leadership planning and implementation group. The eight members represent all three JAXCC campuses and have overall responsibility for implementing the strategic plan and recommendations by the EAB. They direct the JAXCC pilot project program with emphasis on using the CCSG developmental funds to advance the strategic goals. The Seminar Program serves the planning function by bringing external cancer researchers to campus. 67 distinguished speakers presented seminars of cancer-relevance to the JAXCC members in the previous grant cycle. In the next grant cycle, the seminar program will be institutionally funded. Priority will be given to speakers who can open doors for translational research partnerships.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA034196-29
Application #
8699298
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-08-01
Project End
2019-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
29
Fiscal Year
2014
Total Cost
$11,326
Indirect Cost
$4,854
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Rutherford, Sarah C; Fachel, Angela A; Li, Sheng et al. (2018) Extracellular vesicles in DLBCL provide abundant clues to aberrant transcriptional programming and genomic alterations. Blood 132:e13-e23
Barthel, Floris P; Wesseling, Pieter; Verhaak, Roel G W (2018) Reconstructing the molecular life history of gliomas. Acta Neuropathol 135:649-670
Winer, Benjamin Y; Shirvani-Dastgerdi, Elham; Bram, Yaron et al. (2018) Preclinical assessment of antiviral combination therapy in a genetically humanized mouse model for hepatitis delta virus infection. Sci Transl Med 10:
Kim, Hyunsoo; Kumar, Pooja; Menghi, Francesca et al. (2018) High-resolution deconstruction of evolution induced by chemotherapy treatments in breast cancer xenografts. Sci Rep 8:17937
Schechter, Lisa M; Creely, David P; Garner, Cherilyn D et al. (2018) Extensive Gene Amplification as a Mechanism for Piperacillin-Tazobactam Resistance in Escherichia coli. MBio 9:
Barthel, Floris P; Johnson, Kevin C; Wesseling, Pieter et al. (2018) Evolving Insights into the Molecular Neuropathology of Diffuse Gliomas in Adults. Neurol Clin 36:421-437
Vian, Laura; P?kowska, Aleksandra; Rao, Suhas S P et al. (2018) The Energetics and Physiological Impact of Cohesin Extrusion. Cell 173:1165-1178.e20
Tarchini, Basile; Longo-Guess, Chantal; Tian, Cong et al. (2018) A spontaneous mouse deletion in Mctp1 uncovers a long-range cis-regulatory region crucial for NR2F1 function during inner ear development. Dev Biol 443:153-164
Garrett, Andrew M; Khalil, Andre; Walton, David O et al. (2018) DSCAM promotes self-avoidance in the developing mouse retina by masking the functions of cadherin superfamily members. Proc Natl Acad Sci U S A 115:E10216-E10224
Huang, Bin; Jia, Dongya; Feng, Jingchen et al. (2018) RACIPE: a computational tool for modeling gene regulatory circuits using randomization. BMC Syst Biol 12:74

Showing the most recent 10 out of 1156 publications