The Cancer Model Development Resource (CMDR) at JAX is a component of Genetic Resource Science (GRS), a group of over 100 people with broad expertise in mouse genetics and molecular biology necessary to manipulate the mouse genome. Dr. Leah Rae Donahue, Director of Genetic Resource Sciences, and Dr. Leonard Shultz, Professor, co-lead the CMDR. The CMDR provides JAX Cancer Center (JAXCC) investigators access to existing cancer models and supports development of new mouse models tailored to specific cancer research questions of importance to the Cancer Center. In turn, these models are made available to the JAXCC and wider scientific community through the GRS Repository. The CMDR provides JAXCC investigators access to mouse strains, the expertise of scientists in the Genetic Resource Science program, and project management. The GRS Repository is the largest single collection of genetically defined mouse strains anywhere in the world, and maintains an enormous variety of live strains (~1,600 at any given time), while other strains are maintained as cryopreserved stocks. To encourage use ofthe live resource, JAXCC members are supplied with mice free of charge, either as breeding pairs, small numbers of mutants and controls from mutant strains, or individual mice from strain panels. Additionally, the CMDR provides project management and genetic expertise to facilitate the development of cancer models by xenografts of human cancer samples into the NSG (NOD.Cg-Prkcdc[scid]//2rg[tm1Wji]/SzJ) mouse developed by Dr. Shultz. The CMDR advises JAXCC members who wish to develop specialized host strains tailored for particular scientific questions. Models are also developed for other research applications by combining mutant alleles to make compound mutant stocks. The CMDR and coordinates the model development process, working with the Genetic Engineering Technologies and Phenotyping Technologies resources as needed. The CMDR project manager coordinates animal care, management of biological materials, and surgical services to facilitate model development. The long-term objective is assist JAXCC members in their research by enabling the use ofthe full suite of genetic manipulation techniques and mouse model development.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Jackson Laboratory
Bar Harbor
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Song, Delu; Grieco, Steve; Li, Yafeng et al. (2014) A murine RP1 missense mutation causes protein mislocalization and slowly progressive photoreceptor degeneration. Am J Pathol 184:2721-9
Chow, Kin-Hoe; Shin, Dong-Mi; Jenkins, Molly H et al. (2014) Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity. Cancer Res 74:4864-74
King Jr, Lloyd E; Silva, Kathleen A; Kennedy, Victoria E et al. (2014) Lack of response to laser comb in spontaneous and graft-induced alopecia areata in C3H/HeJ mice. J Invest Dermatol 134:264-6
Low, Benjamin E; Krebs, Mark P; Joung, J Keith et al. (2014) Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair. Invest Ophthalmol Vis Sci 55:387-95
Potter, Christopher S; Wang, Zhe; Silva, Kathleen A et al. (2014) Chronic proliferative dermatitis in Sharpin null mice: development of an autoinflammatory disease in the absence of B and T lymphocytes and IL4/IL13 signaling. PLoS One 9:e85666
Hosur, Vishnu; Johnson, Kenneth R; Burzenski, Lisa M et al. (2014) Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. Proc Natl Acad Sci U S A 111:E2200-9
Roderick, Justine E; Tesell, Jessica; Shultz, Leonard D et al. (2014) c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood 123:1040-50
Korstanje, Ron; Caputo, Christina R; Doty, Rosalinda A et al. (2014) A mouse Col4a4 mutation causing Alport glomerulosclerosis with abnormal collagen ?3?4?5(IV) trimers. Kidney Int 85:1461-8
Grubb, Stephen C; Bult, Carol J; Bogue, Molly A (2014) Mouse phenome database. Nucleic Acids Res 42:D825-34
Inaki, Koichiro; Menghi, Francesca; Woo, Xing Yi et al. (2014) Systems consequences of amplicon formation in human breast cancer. Genome Res 24:1559-71

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