The UNMC Eppley Cancer Center is an NCI-designated matrix Cancer Center at the University of Nebraska Medical Center (UNMC) conducting a wide range of basic, clinical, translational and population science research. The Cancer Center Director reports directly to the Chancellor of UNMC, and also serves as Director of the Eppley Institute for Cancer Research, a multidisciplinary cancer research unit. NCI-defined peer-reviewed funding for the Cancer Center is currently over $40 M (annual direct costs), a 1.25 fold increase since 2004. In addition, NCI funding for the Cancer Center increased nearly $6 M (direct costs) since the last review and now accounts for almost 40% of peer-reviewed funding in the Cancer Center. The Cancer Center has been in a dynamic growth phase with recruitment of 39 members since the last review. The Cancer Center continues to enjoy outstanding support from the state of Nebraska. Over the past five years, the Cancer Center has received almost $43 M in state and institutional support and over $12 M in philanthropic support. State support provided resources for new facilities, faculty recruitment and enhanced shared resources, including the construction of a $20 M Cellular Good Manufacturing Practices (cGMP) facility and establishment of a high-throughput Genome-wide RNAi Screening Facility. The opening of the $76 M Durham Research Center II (DRC II) in 2009, the ECC was assigned 2 floors (64,000 gsf) of additional research space and now has a total of 270,000 gsf of laboratory space under the authority of the Director. A new multidisciplinary Cancer Clinic was opened in west Omaha in 2008, providing 60,000 gsf of new clinic and treatment facilities. Since the last review, 26 clinical faculty were recruited and the Cancer Center signed Affiliation Agreements with four hospitals across the state providing expanded access to Cancer Center clinical trials. The Cancer Center has three translationally oriented research programs: 1) Cancer Genes and Molecular Regulation;2) Molecular and Biochemical Etiology of Cancer;and 3) Lymphoma Research Program and a developing program in Cancer Control and Prevention. Translational research is also facilitated through disease-oriented research working groups including breast cancer, prostate cancer, and pancreatic cancer. The Cancer Center also supports ten shared resources: Bioinformatics, Biostatistics, Cell Analysis, Centralized Protocol Data Management Unit, Confocal Microscopy, Laboratory Support, Molecular Biology, Monoclonal Antibody, Pathology, and Structural Biology.
The mission of the UNMC Eppley Cancer Center is to coordinate basic research and clinical cancer research, patient care and educational programs, to facilitate application of new knowledge about the etiology, diagnosis, treatment and prevention of cancer and to improve health and quality of life. In short, through its efforts to reduce the impact of cancer, as well as the threat of cancer in the future, the UNMC Eppley Cancer Center's mission and activities are extremely relevant to public health.
|Lockridge, Oksana; David, Emilie; Schopfer, Lawrence M et al. (2018) Purification of recombinant human butyrylcholinesterase on Hupresin®. J Chromatogr B Analyt Technol Biomed Life Sci 1102-1103:109-115|
|Saxena, Sugandha; Hayashi, Yuri; Wu, Lingyun et al. (2018) Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis. Oncotarget 9:5931-5943|
|Souza, Nathália P; Hard, Gordon C; Arnold, Lora L et al. (2018) Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN). Toxicol Pathol 46:266-272|
|Ray, Sutapa; Coulter, Don W; Gray, Shawn D et al. (2018) Suppression of STAT3 NH2 -terminal domain chemosensitizes medulloblastoma cells by activation of protein inhibitor of activated STAT3 via de-repression by microRNA-21. Mol Carcinog 57:536-548|
|Kanvinde, Shrey; Chhonker, Yashpal Singh; Ahmad, Rizwan et al. (2018) Pharmacokinetics and efficacy of orally administered polymeric chloroquine as macromolecular drug in the treatment of inflammatory bowel disease. Acta Biomater 82:158-170|
|Payne, William M; Svechkarev, Denis; Kyrychenko, Alexander et al. (2018) The role of hydrophobic modification on hyaluronic acid dynamics and self-assembly. Carbohydr Polym 182:132-141|
|Sanchez, Sonia M Rocha; Fuson, Olivia; Tarang, Shikha et al. (2018) Quinoxaline protects zebrafish lateral line hair cells from cisplatin and aminoglycosides damage. Sci Rep 8:15119|
|Stepchenkova, E I; Shiriaeva, A A; Pavlov, Y I (2018) Deletion of the DEF1 gene does not confer UV-immutability but frequently leads to self-diploidization in yeast Saccharomyces cerevisiae. DNA Repair (Amst) 70:49-54|
|Wang, Zhan; Chen, Xingcheng; Zhong, Mei-Zuo et al. (2018) Cyclin-dependent kinase 1-mediated phosphorylation of YES links mitotic arrest and apoptosis during antitubulin chemotherapy. Cell Signal 52:137-146|
|Svechkarev, Denis; Kyrychenko, Alexander; Payne, William M et al. (2018) Probing the self-assembly dynamics and internal structure of amphiphilic hyaluronic acid conjugates by fluorescence spectroscopy and molecular dynamics simulations. Soft Matter 14:4762-4771|
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