The overall goal of the Structural Biology (SB) Facility is to apply structural techniques to the analysis of important cancer-related biological macromolecules, to provide basic knowledge of disease mechanism, drive research and direct the synthesis of novel therapeutics.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA036727-27
Application #
8566893
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
27
Fiscal Year
2013
Total Cost
$72,845
Indirect Cost
$23,791
Name
University of Nebraska Medical Center
Department
Type
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198
Tadros, Saber; Shukla, Surendra K; King, Ryan J et al. (2017) De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer. Cancer Res 77:5503-5517
Gong, Qiang; Wang, Chao; Zhang, Weiwei et al. (2017) Assessment of T-cell receptor repertoire and clonal expansion in peripheral T-cell lymphoma using RNA-seq data. Sci Rep 7:11301
Lakshmanan, Imayavaramban; Salfity, Shereen; Seshacharyulu, Parthasarathy et al. (2017) MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53. Clin Cancer Res 23:3906-3917
Romereim, Sarah M; Summers, Adam F; Pohlmeier, William E et al. (2017) Transcriptomes of bovine ovarian follicular and luteal cells. Data Brief 10:335-339
Wu, Shaohua; Xu, Ranjie; Duan, Bin et al. (2017) Three-Dimensional Hyaluronic Acid Hydrogel-Based Models for In Vitro Human iPSC-Derived NPC Culture and Differentiation. J Mater Chem B 5:3870-3878
Hendershot, Jenna M; O'Brien, Patrick J (2017) Search for DNA damage by human alkyladenine DNA glycosylase involves early intercalation by an aromatic residue. J Biol Chem 292:16070-16080
Roychoudhury, Shrabasti; Nath, Somsubhra; Song, Heyu et al. (2017) Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity. Mol Cell Biol 37:
Wu, Shaohua; Wang, Ying; Streubel, Philipp N et al. (2017) Living nanofiber yarn-based woven biotextiles for tendon tissue engineering using cell tri-culture and mechanical stimulation. Acta Biomater 62:102-115
Payne, William M; Hill, Tanner K; Svechkarev, Denis et al. (2017) Multimodal Imaging Nanoparticles Derived from Hyaluronic Acid for Integrated Preoperative and Intraoperative Cancer Imaging. Contrast Media Mol Imaging 2017:9616791
Trease, Andrew J; Capuccino, Juan M V; Contreras, Jorge et al. (2017) Intramolecular signaling in a cardiac connexin: Role of cytoplasmic domain dimerization. J Mol Cell Cardiol 111:69-80

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