The overall goal of the Structural Biology (SB) Facility is to apply structural techniques to the analysis of important cancer-related biological macromolecules, to provide basic knowledge of disease mechanism, drive research and direct the synthesis of novel therapeutics.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA036727-27
Application #
8566893
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
27
Fiscal Year
2013
Total Cost
$72,845
Indirect Cost
$23,791
Name
University of Nebraska Medical Center
Department
Type
DUNS #
168559177
City
Omaha
State
NE
Country
United States
Zip Code
68198
Xie, Shuwei; Bahl, Kriti; Reinecke, James B et al. (2016) The endocytic recycling compartment maintains cargo segregation acquired upon exit from the sorting endosome. Mol Biol Cell 27:108-26
Hanson, Ryan L; Brown, Roger B; Steele, Maria M et al. (2016) Identification of FRA-1 as a novel player in pancreatic cancer in cooperation with a MUC1: ERK signaling axis. Oncotarget 7:39996-40011
Hill, Tanner K; Mohs, Aaron M (2016) Image-guided tumor surgery: will there be a role for fluorescent nanoparticles? Wiley Interdiscip Rev Nanomed Nanobiotechnol 8:498-511
Pai, Priya; Rachagani, Satyanarayana; Dhawan, Punita et al. (2016) MUC4 is negatively regulated through the Wnt/β-catenin pathway via the Notch effector Hath1 in colorectal cancer. Genes Cancer 7:154-68
Spagnol, Gaelle; Kieken, Fabien; Kopanic, Jennifer L et al. (2016) Structural Studies of the Nedd4 WW Domains and Their Selectivity for the Connexin43 (Cx43) Carboxyl Terminus. J Biol Chem 291:7637-50
Hill, Tanner K; Davis, Amanda L; Wheeler, Frances B et al. (2016) Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines. Mol Pharm 13:720-8
Wuebben, Erin L; Wilder, Phillip J; Cox, Jesse L et al. (2016) SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells. Oncotarget 7:34890-906
Kelkar, Sneha S; Hill, Tanner K; Marini, Frank C et al. (2016) Near infrared fluorescent nanoparticles based on hyaluronic acid: Self-assembly, optical properties, and cell interaction. Acta Biomater 36:112-21
Marr, Alissa S; Zhang, Chi; Ganti, Apar Kishor (2016) Resected small cell lung cancer-time for more? J Thorac Dis 8:E755-7
Fox, Raymond G; Lytle, Nikki K; Jaquish, Dawn V et al. (2016) Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma. Nature 534:407-11

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