The Staff Investigator Position of this application was assembled with the specific intention to formalize and expand the activities of an important Huntsman Cancer Institute (HCI) investigator. Dr. Lisa Cannon- Albright. A summary of Dr. Cannon-Albright's qualifications and activities is provided below. The activities proposed contribute specifically to our Cancer Center goal of maximizing achievement in individualized oncology. Dr. Cannon-Albright extensively utilizes our unique resource, the Utah Population Database (UPDB), the only database of its kind in the United States and one of few such resources in the worid. This is a rich source of information for genetic, epidemiological, demographic, and public health studies. Such discoveries have implications for translation regarding individualized cancer susceptibility testing and appropriate surveillance;individual cancer treatment responses for planning optimal therapies;and, identification of targets of intervention for suggesting novel therapies tailored to the individual. Through cancer susceptibility chromosomal loci and gene identification, the Staff Investigator will initiate translational and transdisciplinary investigations characterized by the following: 1) Cooperation between high-risk cancer populations and clinicians focused on prevention and patient care. 2) Development of preclinical models of disease through interactions among clinical trial researchers 3) Interactions between basic scientists interested in genomics and signaling pathways and investigators focused on high-risk populations and clinical trial development. 4) Collaborations among genetic epidemiologists, basic scientists, and clinical prevention specialists.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA042014-24
Application #
8465106
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
24
Fiscal Year
2013
Total Cost
$45,151
Indirect Cost
$21,836
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
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Lerman, Daniel M; Monument, Michael J; McIlvaine, Elizabeth et al. (2015) Tumoral TP53 and/or CDKN2A alterations are not reliable prognostic biomarkers in patients with localized Ewing sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer 62:759-65
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Clark, Kathleen A; Graves, Barbara J (2014) Dual views of SRF: a genomic exposure. Genes Dev 28:926-8
Oakley, Gretchen M; Curtin, Karen; Layfield, Lester et al. (2014) Increased melanoma risk in individuals with papillary thyroid carcinoma. JAMA Otolaryngol Head Neck Surg 140:423-7
Zhang, Rui; Yang, Jiyuan; Sima, Monika et al. (2014) Sequential combination therapy of ovarian cancer with degradable N-(2-hydroxypropyl)methacrylamide copolymer paclitaxel and gemcitabine conjugates. Proc Natl Acad Sci U S A 111:12181-6
Smith, M A; Hoffman, L M; Beckerle, M C (2014) LIM proteins in actin cytoskeleton mechanoresponse. Trends Cell Biol 24:575-83
Van Vranken, Jonathan G; Bricker, Daniel K; Dephoure, Noah et al. (2014) SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration. Cell Metab 20:241-52
Gibson, Summer B; Figueroa, Karla P; Bromberg, Mark B et al. (2014) Familial clustering of ALS in a population-based resource. Neurology 82:17-22

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