The Imaging, Diagnostics, and Therapeutics Program (IDT) is a new HCI program focused on translating basic discoveries in cancer biology to clinically relevant advanced imaging techniques, diagnostics, drug delivery systems, unique therapeutic approaches, and clinical trials. A major IDT goal is to leverage the strengths of the University of Utah in genetics, pharmaceutics, and imaging along with infrastructure resources to make individualized oncology a reality. An IDT priority has been to increase collaboration with the multidisciplinary disease groups to better understand unmet clinical needs and to bring theoretical and preclinical projects to human applications. IDT is organized along its three thematic scientific strengths: Imaging research efforts include technology development, image-guided therapy, and the new and evolving discipline of molecular imaging. Several Program members are focused on using positron emission tomography imaging with unique radiopharmaceuticals to assess early response to therapeutic intervention. Several members are also involved with image-guided therapy technology development. Diagnostics research efforts include development of novel diagnostic strategies to improve the biologic characterization of cancer for therapeutic treatments and to provide important prognostic information to improve cancer care. Several individuals within the Program are interested in using modern molecular techniques to assess what population of individuals is at risk for developing a certain type of cancer and how particular cancers respond to targeted drug therapies. In addition, prognostic information regarding tumor behavior can be assessed. From these efforts in diagnostic biomarker development, defects in molecular pathways or targets can be identified. Therapeutics research efforts include the development of therapeutic strategies using novel drugs and drug delivery systems. These IDT members perform pre-clinical development, pharmacology, and other required studies to move their discoveries toward clinical applications. Members pursue new drugs and diagnostics through design, compound screening, computational modeling, and chemical synthesis. Members also focus on targeted delivery of anti-cancer agents to tumors and metastases using novel macromolecular drugs and new controlled-release and pro-drug techniques. This thematic group is essential to HCI's clinical trials effort. Led by John M. Hoffman, MD and Wallace Akerley, MD, the IDT Program includes 42 members from 15 departments and four colleges. IDT members include 14 PhDs, 20 MDs, and eight MD/PhDs. As of December 2008, members had $7.2M in peer-reviewed annual direct costs;56% was from NCI. The research efforts of IDT members have resulted in 466 publications, of which 17% were intra- and 15% were interprogrammatic collaborations. During 2008, the IDT Program had 36 investigator-initiated trials and 176 other trials;398 subjects were recruited to therapeutic trials and 3,479 subjects to other trials.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA042014-25
Application #
8661124
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
25
Fiscal Year
2014
Total Cost
$39,992
Indirect Cost
$19,956
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Wang, Sophia S; Carrington, Mary; Berndt, Sonja I et al. (2018) HLA Class I and II Diversity Contributes to the Etiologic Heterogeneity of Non-Hodgkin Lymphoma Subtypes. Cancer Res 78:4086-4096
Faham, Najme; Zhao, Ling; Welm, Alana L (2018) mTORC1 is a key mediator of RON-dependent breast cancer metastasis with therapeutic potential. NPJ Breast Cancer 4:36
Fuller, Andrew K; Bice, Benjamin D; Venancio, Ashlee R et al. (2018) A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model. J Vis Exp :
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Gaffney, David K; Hashibe, Mia; Kepka, Deanna et al. (2018) Too many women are dying from cervix cancer: Problems and solutions. Gynecol Oncol 151:547-554
Rengifo-Cam, William; Shepherd, Hailey M; Jasperson, Kory W et al. (2018) Colon Pathology Characteristics in Li-Fraumeni Syndrome. Clin Gastroenterol Hepatol 16:140-141
Gilcrease, Eddie B; Casjens, Sherwood R (2018) The genome sequence of Escherichia coli tailed phage D6 and the diversity of Enterobacteriales circular plasmid prophages. Virology 515:203-214
Park, Jihye; Blackburn, Brenna E; Rowe, Kerry et al. (2018) Rural-metropolitan disparities in ovarian cancer survival: a statewide population-based study. Ann Epidemiol 28:377-384
Hardy, Christopher M; Burke, Molly K; Everett, Logan J et al. (2018) Genome-Wide Analysis of Starvation-Selected Drosophila melanogaster-A Genetic Model of Obesity. Mol Biol Evol 35:50-65
Wu, Yelena P; Kohlmann, Wendy; Curtin, Karen et al. (2018) Melanoma risk assessment based on relatives' age at diagnosis. Cancer Causes Control 29:193-199

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