The primary goal of the Biostatistics Shared Resource is to provide biostatistical and biomathematical support and collaboration for laboratory, translational, clinical, population, and epidemiological cancer studies underway at Huntsman Cancer Institute (HCI). The Biostatistics Resource enhances the scientific quality and sophistication of cancer research projects by providing tailored, professional consultation at all levels and stages of research. The Resource assists investigators with study design, sample size/power calculations, data analyses, grant applications, and manuscripts. Emphasis is placed on early consultation to allow adequate consideration and adaptation of study designs to meet the main objectives of the research. The Resource also provides educational outreach to Cancer Center members as needed, allowing investigators to better address their specific research problems. The Biostatistics Shared Resource, by virtue of its activities with a broad range of cancer investigators, is central to the Cancer Center's priorities. It is also a focal point of transdisciplinary cancer research, as it facilitates the collaborative work of basic, population, and clinical researchers from many departments. The primary research component of the Biostatistics Resource focuses on carcinogenesis modeling, on methodologies for high throughput genomics applicable to cancer pathways (such as microarray, ChlP-Seq, and Digital Gene Expression), and on methodologies for analysis of familial aspects of cancer. Use of this Shared Resource by the Cancer Center has increased substantially during the most recent cycle, and biostaticians have been involved in numerous important scientific discoveries. Kenneth Boucher, PhD, is the Resource Director and reports to HCI Senior Directors. Since the recent receipt of the University of Utah Clinical and Translational Science Award, Biostatistics is also now affiliated with the biostatistical component of that program. The Resource retains direct Cancer Center management, while the affiliation allows increased depth of expertise combined with increased interaction of institutional biostaticians and related academic activities. The Resource also has an established advisory committee, which regularly reviews structure, quality of service and research, as well as goals and needs. The Resource is housed in the HCI research building. In 2008, usage of the Shared Resource by the Cancer Center was 79 percent. Funds are requested from the CCSG to cover 15 percent ($74,806) of the proposed Biostatistics budget. The Resource is currently near capacity, although the 21 percent of non-Center use could be reprioritized to Cancer Center members should the need arise. Additionally, new recruitment efforts should soon add capacity to this Resource.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA042014-25
Application #
8661138
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
25
Fiscal Year
2014
Total Cost
$58,683
Indirect Cost
$19,955
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Warner, Echo L; Ding, Qian; Pappas, Lisa et al. (2017) Health Care Providers' Knowledge of HPV Vaccination, Barriers, and Strategies in a State With Low HPV Vaccine Receipt: Mixed-Methods Study. JMIR Cancer 3:e12
Affolter, Kajsa; Gligorich, Keith; Samadder, Niloy Jewel et al. (2017) Feasibility of Large-Scale Identification of Sessile Serrated Polyp Patients Using Electronic Records: A Utah Study. Dig Dis Sci 62:1455-1463
Fowler, Brynn; Samadder, N Jewel; Kepka, Deanna et al. (2017) Improvements in Colorectal Cancer Incidence Not Experienced by Nonmetropolitan Women: A Population-Based Study From Utah. J Rural Health :
Ou, Judy Y; Smits-Seemann, Rochelle R; Kaul, Sapna et al. (2017) Risk of hospitalization among survivors of childhood and adolescent acute lymphoblastic leukemia compared to siblings and a general population sample. Cancer Epidemiol 49:216-224
VanderLinden, Ryan T; Hemmis, Casey W; Yao, Tingting et al. (2017) Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism. J Biol Chem 292:9493-9504
Cohen, Adam L; Factor, Rachel E; Mooney, Kathi et al. (2017) POWERPIINC (PreOperative Window of Endocrine TheRapy Provides Information to Increase Compliance) trial: Changes in tumor proliferation index and quality of life with 7 days of preoperative tamoxifen. Breast 31:219-223
Gardiner, Jamie D; Abegglen, Lisa M; Huang, Xiaomeng et al. (2017) C/EBP?-1 promotes transformation and chemoresistance in Ewing sarcoma cells. Oncotarget 8:26013-26026
Ding, Yun; Fleming, Aaron M; Burrows, Cynthia J (2017) Sequencing the Mouse Genome for the Oxidatively Modified Base 8-Oxo-7,8-dihydroguanine by OG-Seq. J Am Chem Soc 139:2569-2572
Carleton, Julia B; Berrett, Kristofer C; Gertz, Jason (2017) Multiplex Enhancer Interference Reveals Collaborative Control of Gene Regulation by Estrogen Receptor ?-Bound Enhancers. Cell Syst 5:333-344.e5
Lai, Run-Zhi; Han, Xue-Sheng; Dahlquist, Frederick W et al. (2017) Paradoxical enhancement of chemoreceptor detection sensitivity by a sensory adaptation enzyme. Proc Natl Acad Sci U S A 114:E7583-E7591

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