RESEARCH INFORMATICS SHARED RESOURCE ABSTRACT The Research Informatics (RI) Shared Resource, established in 1995, provides Cancer Center members state- of-the-art software engineering, database design, and application and web development, as well as cutting- edge expertise in natural language processing, system design, data mining, and electronic data capture systems. Huntsman Cancer Institute (HCI) covers a majority of the costs of this stable, integrated team of computer professionals, enabling their allocation to the ongoing and new initiatives of highest importance to the cancer mission; priorities are determined by the HCI Director's Cabinet. Samir Courdy, BS, MBA, an accomplished computer scientist with expertise in software engineering and development of large-scale software systems, has directed the RI Shared Resource since 2006 and has managed all software development since 2000. Ms. Cindy Spigle, associate director of the RI Resource since 2011, is responsible for daily operations and assists Mr. Courdy in management. To achieve its goals, the RI Shared Resource provides computing infrastructure, hardware equipment, and services, including the latest advances in front-end graphical user interface (GUI) technologies and secure backend database engines and persistence layers. The RI Shared Resource has developed applications and databases for several other HCI-managed Shared Resources, including High-Throughput Genomics and Bioinformatic Analysis, Genetic Counseling, Biorepository and Molecular Pathology, and the Utah Population Database. The RI Shared Resource supports all four of the Cancer Center's Research Programs with the many software suites the team designs, builds, and supports. These include comprehensive suites of software applications for Cancer Clinical Research (CCR); Biospecimen Management and Annotation (itBioPath); a microarray and next-generation sequencing Laboratory Information Management System (LIMS) and experiment analysis and annotation suite (GNomEx); and a drug/chemical screening annotation and management suite (CSAM). CCR, itBioPath, and GNomEx are integrated systems providing genotype and phenotype associations for research. As software development is beyond the budget of most individual researchers, the RI Shared Resource adds important value to the Cancer Center by enabling a wide variety of researchers to utilize customized software tools without substantial financial investments. The Resource also provides cost savings to researchers by obtaining grant and institutional support to help offset software development costs. In 2013, use of the RI Shared Resource by Cancer Center members with peer-reviewed funding exceeded 57%, while the CCSG budget request is only 6% ($123,370) of the total proposed budget.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA042014-29
Application #
9478881
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
29
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
009095365
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Fowler, Brynn; Samadder, N Jewel; Kepka, Deanna et al. (2018) Improvements in Colorectal Cancer Incidence Not Experienced by Nonmetropolitan Women: A Population-Based Study From Utah. J Rural Health 34:155-161
Grieshober, Laurie; Graw, Stefan; Barnett, Matt J et al. (2018) Methylation-derived Neutrophil-to-Lymphocyte Ratio and Lung Cancer Risk in Heavy Smokers. Cancer Prev Res (Phila) 11:727-734
Burch, Joseph S; Marcero, Jason R; Maschek, John Alan et al. (2018) Glutamine via ?-ketoglutarate dehydrogenase provides succinyl-CoA for heme synthesis during erythropoiesis. Blood 132:987-998
Guo, Jingtao; Grow, Edward J; Mlcochova, Hana et al. (2018) The adult human testis transcriptional cell atlas. Cell Res 28:1141-1157
Philip, Beatrice; Yu, Diana X; Silvis, Mark R et al. (2018) Mutant IDH1 Promotes Glioma Formation In Vivo. Cell Rep 23:1553-1564
Sadler, Jessica B A; Wenzel, Dawn M; Williams, Lauren K et al. (2018) A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability. Proc Natl Acad Sci U S A 115:E8900-E8908
Piñas, Germán E; DeSantis, Michael D; Parkinson, John S (2018) Noncritical Signaling Role of a Kinase-Receptor Interaction Surface in the Escherichia coli Chemosensory Core Complex. J Mol Biol 430:1051-1064
Rambau, Peter F; Vierkant, Robert A; Intermaggio, Maria P et al. (2018) Association of p16 expression with prognosis varies across ovarian carcinoma histotypes: an Ovarian Tumor Tissue Analysis consortium study. J Pathol Clin Res 4:250-261
Stump, Tammy K; Aspinwall, Lisa G; Kohlmann, Wendy et al. (2018) Genetic Test Reporting and Counseling for Melanoma Risk in Minors May Improve Sun Protection Without Inducing Distress. J Genet Couns 27:955-967
Rogers, R Aaron; Fleming, Aaron M; Burrows, Cynthia J (2018) Unusual Isothermal Hysteresis in DNA i-Motif pH Transitions: A Study of the RAD17 Promoter Sequence. Biophys J 114:1804-1815

Showing the most recent 10 out of 1193 publications