The Comprehensive Cancer Center of Case Western Reserve University (CWRU) and University Hospitals of Cleveland (UHC) is an NCI-designated Comprehensive Cancer Center that combines the resources and expertise of its two parent institutions. The Center is organized as a matrix center with seven interdisciplinary scientific programs and ten multidisciplinary disease-oriented clinical teams. Research programs of the Center extend to CWRU affiliated hospitals including the Louis Stokes Veterans Affairs Hospital, the MetroHealth Medical Center (the region?s county hospital), and the Henry Ford Health System in Detroit. Fourteen shared resources operated by the Center enable cancer research. A patient education and information office provides the 4.5 million people of the Northern Ohio region with information on cancer diagnosis, treatment and prevention, as well as information on access to clinical research trials. The Center has experienced dynamic growth during the past five years including the development of a new program in cancer prevention, control and population research, recruitment of twenty-four new members from outside the institution, and the development of four new shared resources. Membership in the Center has grown to 200 members representing 23 departments and 6 schools across the University. Strong institutional support including plans for new Cancer Center research space provide outstanding opportunities for this growth to continue. The objectives of the Center are: 1) to improve the prevention, diagnosis, and therapy of cancer through research; 2) to stimulate and support innovative, coordinated, interdisciplinary research on cancer diagnosis, treatment, and control; 3) to develop clinical applications of research discoveries and to make these applications available to Northeastern Ohio residents as quickly as possible; and 4) to develop cancer prevention and control activities that most effectively utilize the clinical and laboratory expertise at CWRU and UHC and contribute to the reduction of cancer morbidity and mortality in Northeast Ohio and the surrounding region and nation.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA043703-17
Application #
6948625
Study Section
Subcommittee G - Education (NCI)
Program Officer
Silkensen, Shannon M
Project Start
1991-09-30
Project End
2007-07-31
Budget Start
2005-08-01
Budget End
2007-07-31
Support Year
17
Fiscal Year
2005
Total Cost
$4,438,149
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Augestad, Knut M; Keller, Deborah S; Bakaki, Paul M et al. (2018) The impact of rectal cancer tumor height on recurrence rates and metastatic location: A competing risk analysis of a national database. Cancer Epidemiol 53:56-64
Chen, Lechuang; Feng, Zhimin; Yue, Hong et al. (2018) Exosomes derived from HIV-1-infected cells promote growth and progression of cancer via HIV TAR RNA. Nat Commun 9:4585
Patel, Rutulkumar; Zhang, Luchang; Desai, Amar et al. (2018) Mlh1 deficiency increases the risk of hematopoietic malignancy after simulated space radiation exposure. Leukemia :
Lager, Angela M; Corradin, Olivia G; Cregg, Jared M et al. (2018) Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells. Nat Commun 9:3708
Patel, Rutulkumar; Qing, Yulan; Kennedy, Lucy et al. (2018) MMR Deficiency Does Not Sensitize or Compromise the Function of Hematopoietic Stem Cells to Low and High LET Radiation. Stem Cells Transl Med 7:513-520
Desai, Amar; Zhang, Yongyou; Park, Youngsoo et al. (2018) A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support. Haematologica 103:1054-1064
Cummings III, Kenneth C; Zimmerman, Nicole M; Maheshwari, Kamal et al. (2018) Epidural compared with non-epidural analgesia and cardiopulmonary complications after colectomy: A retrospective cohort study of 20,880 patients using a national quality database. J Clin Anesth 47:12-18
Thiagarajan, Praveena S; Sinyuk, Maksim; Turaga, Soumya M et al. (2018) Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase. Nat Commun 9:578
Qiu, Zhaojun; Oleinick, Nancy L; Zhang, Junran (2018) ATR/CHK1 inhibitors and cancer therapy. Radiother Oncol 126:450-464
Elitt, Matthew S; Shick, H Elizabeth; Madhavan, Mayur et al. (2018) Chemical Screening Identifies Enhancers of Mutant Oligodendrocyte Survival and Unmasks a Distinct Pathological Phase in Pelizaeus-Merzbacher Disease. Stem Cell Reports 11:711-726

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