The Behavioral Measurement Core provides support to members of the Case CCC for study design and protocol development for studies involving behavioral measures, selection of existing measures or new instrument design, data analysis, manuscript preparation and review, and grant application development and review. Case CCC members from the Prevention Program primarily utilize the Core services. The Core supports clinical, prevention and other cancer research by assisting investigators in behavioral research methods including identifying or adapting existing measures of behavioral constructs, or when needed, developing new measures to fit investigator research questions and hypotheses. Parallel to designing a study with sufficient sample size and power to test associations, careful selection of the most reliable and valid measures can impact the ability to adequately evaluate the study hypotheses. Qualitative methods are often used in the early stages of measurement to guide understanding and define complex phenomena prior to developing a new measure. The Core is an important asset to investigators of the Cancer Center who conduct behavioral and population based research. It has enabled the development of the Center's research themes in prevention, population and control research. It has also opened up options for greater inclusion of patient report measures, such as quality of life, in treatment and prevention clinical trials. The Core's support of mixed methods, multilevel study designs and modern measurement theory creates a strategic advantage for investigators and is responsive to new developments and methods expectations in recent NCI initiatives. The Core creates an infrastructure for increasing transdisciplinary collaboration within and across Cancer Center programs. The incorporation of behavioral measures into ROI applications and the inclusion of psychometric and statistical analysis of ongoing funded studies also are indicative of the value added to the Cancer Center.

Public Health Relevance

The Case Comprehensive Cancer Center is Northeast Ohio's only NCI designated comprehensive cancer center providing bench-to-bedside medical research involving partnerships between basic, clinical and population scientists to speed translation of laboratory discoveries into new prevention/intervention and cancer treatments.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA043703-23
Application #
8484966
Study Section
Subcommittee G - Education (NCI)
Project Start
1997-08-01
Project End
2018-03-31
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
23
Fiscal Year
2013
Total Cost
$82,655
Indirect Cost
$30,257
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Zhao, S; Sedwick, D; Wang, Z (2015) Genetic alterations of protein tyrosine phosphatases in human cancers. Oncogene 34:3885-94
Dermawan, Josephine Kam Tai; Gurova, Katerina; Pink, John et al. (2014) Quinacrine overcomes resistance to erlotinib by inhibiting FACT, NF-?B, and cell-cycle progression in non-small cell lung cancer. Mol Cancer Ther 13:2203-14
Brubaker, Douglas; Difeo, Analisa; Chen, Yanwen et al. (2014) Drug Intervention Response Predictions with PARADIGM (DIRPP) identifies drug resistant cancer cell lines and pathway mechanisms of resistance. Pac Symp Biocomput :125-35
Yori, Jennifer L; Lozada, Kristen L; Seachrist, Darcie D et al. (2014) Combined SFK/mTOR inhibition prevents rapamycin-induced feedback activation of AKT and elicits efficient tumor regression. Cancer Res 74:4762-71
Dabir, Snehal; Kluge, Amy; McColl, Karen et al. (2014) PIAS3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status. Int J Cancer 134:1045-54
Zapanta Rinonos, Serendipity; Rai, Urvashi; Vereb, Sydney et al. (2014) Sequential logic of polarity determination during the haploid-to-diploid transition in Saccharomyces cerevisiae. Eukaryot Cell 13:1393-402
Sizemore, Gina M; Sizemore, Steven T; Seachrist, Darcie D et al. (2014) GABA(A) receptor pi (GABRP) stimulates basal-like breast cancer cell migration through activation of extracellular-regulated kinase 1/2 (ERK1/2). J Biol Chem 289:24102-13
Sossey-Alaoui, Khalid; Pluskota, Elzbieta; Davuluri, Gangarao et al. (2014) Kindlin-3 enhances breast cancer progression and metastasis by activating Twist-mediated angiogenesis. FASEB J 28:2260-71
Dotan, Efrat; Devarajan, Karthik; D'Silva, A James et al. (2014) Patterns of use and tolerance of anti-epidermal growth factor receptor antibodies in older adults with metastatic colorectal cancer. Clin Colorectal Cancer 13:192-8
Arachiche, Amal; de la Fuente, MarĂ­a; Nieman, Marvin T (2014) Platelet specific promoters are insufficient to express protease activated receptor 1 (PAR1) transgene in mouse platelets. PLoS One 9:e97724

Showing the most recent 10 out of 975 publications