This application seeks renewed CCSG funding for the University of Virginia (UVA) Cancer Center, a matrix cancer center that brings together 132 Members from 23 Departments in the Schools of Medicine, Nursing, and Engineering, and in the College of Arts and Sciences. The UVA Cancer Center receives $19.85M from NCI, $48.62M from other peer-reviewed sources, and $8.72M from non-peer-reviewed sources, for a total of $77.19M in overall funding. Through faculty recruitment, re-organization, and robust infrastructure development, the UVA Cancer Center has continued to build on its exceptional basic-science foundations and has greatly enhanced its ability to accelerate clinical and translational cancer-focused research. Twenty-six new faculties have been recruited, including thirteen clinical investigators and/or physician-scientists and eight bioengineers, computational biologists, and/or molecular geneticists. To enhance trans-disciplinary and translational research and cancer focus, programs were consolidated so that all have basic science Members integrated with disease-focused and clinical or translational investigators. The Cancer Center has five Programs;Cancer Cell Signaling (SIG), Chemical and Structural Biology (CSB), Molecular Genetics and Epigenetics (GEN), Women's Oncology (WON), and Immunology/immunotherapy (IMM). The number of Full Members has been reduced by 30% and an Associate Member category has been created for investigators whose potential for peer-reviewed, cancer-focused research has yet to be actualized. This application requests support for eight Shared Resources: Advanced Microscopy, Biomolecular Analysis, Biorepository and Tissue Research, Flow Cytometry, Gene Targeting and Transgenic, Preclinical Tumor Analysis and Imaging, Biostatistics, and the Office for Clinical Research. A completely transformed infrastructure for translational and clinical research facilitates investigations using human tissues and the implementation of clinical trials. Major additions in research and clinical facilities strongly enhance the Cancer Center's ability to carry out its mission: New laboratory space covering 25,000 ft2houses IMM and WON Members, and a new cancer outpatient clinical building covering 151,000 ft2 will open in April 2011. Substantial activities have been initiated to reach underserved populations in minority groups and in Appalachia. This renewal application describes continued excellence in basic cancer research, enhanced cancer focus, and greatly strengthened clinical research leadership and infrastructure.
The UVA Cancer Center's dual mission is to eliminate the threat of cancer, with skilled, compassionate care for the patients of today and with research and education for the patients of the future. Cancer Center Members draw on the deep resources of the University of Virginia to identify, analyze, and validate some of the most significant targets for cancer therapy, diagnosis and prevention, and to speed their translation to clinical application.
|Melssen, Marit; Slingluff Jr, Craig L (2017) Vaccines targeting helper T cells for cancer immunotherapy. Curr Opin Immunol 47:85-92|
|Bullock, Timothy Nj (2017) TNF-receptor superfamily agonists as molecular adjuvants for cancer vaccines. Curr Opin Immunol 47:70-77|
|Scalici, Jennifer M; Arapovic, Sanja; Saks, Erin J et al. (2017) Mesothelium expression of vascular cell adhesion molecule-1 (VCAM-1) is associated with an unfavorable prognosis in epithelial ovarian cancer (EOC). Cancer 123:977-984|
|Shukla, Girja S; Olson, Walter C; Pero, Stephanie C et al. (2017) Vaccine-draining lymph nodes of cancer patients for generating anti-cancer antibodies. J Transl Med 15:180|
|Keim-Malpass, Jessica; Mitchell, Emma M; DeGuzman, Pamela B et al. (2017) Legislative activity related to the human papillomavirus (HPV) vaccine in the United States (2006-2015): a need for evidence-based policy. Risk Manag Healthc Policy 10:29-32|
|Mills, Anne M; Paquette, Cherie; Terzic, Tatjana et al. (2017) CK7 Immunohistochemistry as a Predictor of CIN1 Progression: A Retrospective Study of Patients From the Quadrivalent HPV Vaccine Trials. Am J Surg Pathol 41:143-152|
|Rohani, Ali; Moore, John H; Kashatus, Jennifer A et al. (2017) Label-Free Quantification of Intracellular Mitochondrial Dynamics Using Dielectrophoresis. Anal Chem 89:5757-5764|
|Wages, N A; Slingluff Jr, C L; Petroni, G R (2017) Statistical controversies in clinical research: early-phase adaptive design for combination immunotherapies. Ann Oncol 28:696-701|
|O'Brien, Carleigh A; Overall, Christopher; Konradt, Christoph et al. (2017) CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection. J Immunol 198:4054-4061|
|Bullock, Timothy Nj (2017) Stimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer. Curr Opin Immunol 45:82-88|
Showing the most recent 10 out of 472 publications