Cold Spring Harbor Laboratory has three Cancer Center Programs that focus on various aspects of understanding cancer. The Cancer Genetics Program (GR), headed by Dr. Gregory Hannon, focuses on approaches to understanding tumor development, progression and therapy response, using sophisticated tools for genome analysis, innovative animal models and genomics, and computational methods. The Gene Regulation and Cell Proliferation Program (GR), led by Dr. David Spector, has three main focus areas - DNA replication, epigenetics and RNA biology - with a central aim of understanding the regulation of gene expression and aim of understanding the regulation of gene expression and cell proliferation in both normal and cancer cells using various experimental systems as well as structural biology. Members of the Signal Transduction Program (ST), led by Dr. Nicholas Tonks, define the mechanisms by which critical signaling pathways are perturbed in cancer and influence essential functions of cancer cells. The program leaders play an important role in promoting the success of their program by setting its overall direction, allocating resources within the program, as well as through their active involvement in faculty recruitment. They also integrate Individual scientific needs of members within the program through the improvement and development of scientific shared resources. Each program leader facilitates interactions between program members through both formal and informal meetings with individual investigators or groups of investigators. The progress in all three programs has been outstanding and has profoundly advanced our understanding of cancer. The success results in large part from the interactive environment promoted by the Cancer Center.

Public Health Relevance

The Program leaders oversee three research programs in the Cancer Center that focus on understanding molecular and genetic mechanisms of cancer and promote this knowledge to develop new therapeutic strategies.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Cold Spring Harbor Laboratory
Cold Spring Harbor
United States
Zip Code
Krishnan, Navasona; Konidaris, Konstantis F; Gasser, Gilles et al. (2018) A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem 293:1517-1525
Borges, Filipe; Parent, Jean-Sébastien; van Ex, Frédéric et al. (2018) Transposon-derived small RNAs triggered by miR845 mediate genome dosage response in Arabidopsis. Nat Genet 50:186-192
Chen, Xiaoyin; Sun, Yu-Chi; Church, George M et al. (2018) Efficient in situ barcode sequencing using padlock probe-based BaristaSeq. Nucleic Acids Res 46:e22
Tonelli, Claudia; Chio, Iok In Christine; Tuveson, David A (2018) Transcriptional Regulation by Nrf2. Antioxid Redox Signal 29:1727-1745
Kumar, Vijay; Rosenbaum, Julie; Wang, Zihua et al. (2018) Partial bisulfite conversion for unique template sequencing. Nucleic Acids Res 46:e10
Lee, Je H (2018) Tracing single-cell histories. Science 359:521-522
Alexander, Joan; Kendall, Jude; McIndoo, Jean et al. (2018) Utility of Single-Cell Genomics in Diagnostic Evaluation of Prostate Cancer. Cancer Res 78:348-358
Huang, Yu-Han; Klingbeil, Olaf; He, Xue-Yan et al. (2018) POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes Dev 32:915-928
Tiriac, Hervé; Belleau, Pascal; Engle, Dannielle D et al. (2018) Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. Cancer Discov 8:1112-1129
Naguib, Adam; Mathew, Grinu; Reczek, Colleen R et al. (2018) Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells. Cell Rep 23:58-67

Showing the most recent 10 out of 380 publications