The Animal Shared Resource offers integral support to CSHL Cancer Center members by providing high quality animal housing, husbandry services, and technical and managerial support to cover all aspects of animal care and use such as tissue biopsies, colony management and protocol implementation. In addition, highly trained personnel teach a variety of specialty skills to researchers, including surgical manipulations and post surgery monitoring, blood and tissue procurement, cesarean re-derivation, tissue perfusion, and therapeutic and virus administration. The veterinary skills of the Animal Shared Resource enable researchers to generate new and innovative mouse cancer models including viral transduction models, multi-allele reversible cancer models, and organoid orthotopic engraftment models of human and mouse cancer. Furthermore, the Animal Shared Resource develops and provides training for implementing new animal protocols. The support provided by the Animal Shared Resource is absolutely fundamental for many research advances in the CSHL Cancer Center. It has enabled researchers to develop innovative animal models for cancer, which continue to be instrumental in uncovering the genetic and molecular basis of the disease. As the CSHL Cancer Center shifts to expand its preclinical and translational research, animal models will become even more important. The Animal Shared Resource enables researchers to move beyond cell culture and to explore cancer biology and cancer medicine in an appropriate in vivo context. In summary, the Animal Shared Resource provides the Cancer Center with a complete set of essential services and sophisticated technical support to facilitate cancer research and discovery. Over the past five years, a total of 27 Cancer Center members (73% of members) utilized the Animal Shared Resource, representing the majority of the facility's use. This Shared Resource contributed to 70 publications by Cancer Center members over this time period.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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Cold Spring Harbor Laboratory
Cold Spring Harbor
United States
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Krishnan, Navasona; Konidaris, Konstantis F; Gasser, Gilles et al. (2018) A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem 293:1517-1525
Borges, Filipe; Parent, Jean-Sébastien; van Ex, Frédéric et al. (2018) Transposon-derived small RNAs triggered by miR845 mediate genome dosage response in Arabidopsis. Nat Genet 50:186-192
Chen, Xiaoyin; Sun, Yu-Chi; Church, George M et al. (2018) Efficient in situ barcode sequencing using padlock probe-based BaristaSeq. Nucleic Acids Res 46:e22
Tonelli, Claudia; Chio, Iok In Christine; Tuveson, David A (2018) Transcriptional Regulation by Nrf2. Antioxid Redox Signal 29:1727-1745
Kumar, Vijay; Rosenbaum, Julie; Wang, Zihua et al. (2018) Partial bisulfite conversion for unique template sequencing. Nucleic Acids Res 46:e10
Lee, Je H (2018) Tracing single-cell histories. Science 359:521-522
Alexander, Joan; Kendall, Jude; McIndoo, Jean et al. (2018) Utility of Single-Cell Genomics in Diagnostic Evaluation of Prostate Cancer. Cancer Res 78:348-358
Huang, Yu-Han; Klingbeil, Olaf; He, Xue-Yan et al. (2018) POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer. Genes Dev 32:915-928
Tiriac, Hervé; Belleau, Pascal; Engle, Dannielle D et al. (2018) Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. Cancer Discov 8:1112-1129
Naguib, Adam; Mathew, Grinu; Reczek, Colleen R et al. (2018) Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells. Cell Rep 23:58-67

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